The cell-lineage and the role of pre-placodal region and sensory placodes during head morphogenesis

• Project/Area Number: 22590179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Jichi Medical University
• Principal Investigator: SATO Shigeru 自治医科大学, 医学部, 准教授 (70306108)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 器官形成 / 感覚器形成 / プラコード / 転写制御 / 胚発生 / ニワトリ / トランスジェニックマウス / 感覚器官 / 解剖学 / 発生生物学 / ニワトリ胚

Research Abstract

Sensory organs of vertebrate heads are formed as follows: ectoderm→pre-placodal region→various sensory placodes. Six1 is the key gene in the process. In this study, we sought to understand the cell-lineage, differentiation and roles of sensory placodes du

Research Products

• [Journal Article] Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods (2012)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K.
  • Journal Title: Dev Biol Volume: 368 Issue: 1 Pages: 95-108
  • DOI: 10.1016/j.ydbio.2012.05.023
  • Peer Reviewed
• [Journal Article] Six family genes control the proliferation and differentiation of muscle satellite cells (2010)
  • Author(s): Yajima H, Motohashi N, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Suzuki Y, Takeda S, Kawakami K
  • Journal Title: Exp Cell Res Volume: 316 Issue: 17 Pages: 2932-2944
  • DOI: 10.1016/j.yexcr.2010.08.001
• [Journal Article] Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR (2010)
  • Author(s): Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H, Kawakami K.
  • Journal Title: Dev Biol Volume: 344 Issue: 1 Pages: 158-171
  • DOI: 10.1016/j.ydbio.2010.04.029
• [Journal Article] Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR (2010)
  • Author(s): Sato, S.
  • Journal Title: Developmental Biology Volume: 344 Pages: 158-171
  • Peer Reviewed
• [Journal Article] Six family genes control the proliferation and differentiation of muscle satellite cells (2010)
  • Author(s): Yajima, H.
  • Journal Title: Experimental Cell Research Volume: 316 Pages: 2932-2944
  • Peer Reviewed
• [Presentation] Six1 homeobox genes in the evolution of the sensory nervous system. (2012)
  • Author(s): Sato S, Yajima H, Kawakami K.
  • Organizer: 学融合推進センター・共同研究プロジェクト研究会「脳の進化-大脳新皮質の起源を尋ねて-」
  • Place of Presentation: 総合研究大学院大学葉山キャンパス共通棟,葉山
  • Year and Date: 2012-11-13
• [Presentation] Conservation and diversity of Six1 gene enhancers in chordates (2012)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Aizawa S, Yajima H, Kawakami K.
  • Organizer: 第45回日本発生生物学会・第64回日本細胞生物学会合同大会
  • Place of Presentation: 神戸国際会議場,神戸
• [Presentation] Conservation and diversity of Six1 gene enhancers in chordates (2012)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Aizawa S, Yajima H, Kawakami K.
  • Organizer: 第45回日本発生生物学会・第64回日本細胞生物学会合同大会
  • Place of Presentation: 神戸国際会議場、神戸
• [Presentation] Six1 enhancers as a tool to understand sensory organogenesis (2011)
  • Author(s): 佐藤滋
  • Organizer: EMBO workshop "Frontiers in sensory development"
  • Place of Presentation: バルセロナ
  • Year and Date: 2011-05-06
• [Presentation] Six1 enhancers as a tool to understand sensory organogenesis. (2011)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Aizawa S, Yajima H, Kawakami K.
  • Organizer: EMBO workshop "Frontiers in sensory development"
  • Place of Presentation: Universitat Pompeu Fabra, Parc de recerca Biomedica (PRBB), Barcelona, Spain
• [Presentation] 脊椎動物の感覚器形成の初期過程の理解を目指して (2010)
  • Author(s): 佐藤滋
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学教養学部、東京
  • Year and Date: 2010-09-25
• [Presentation] 脊椎動物感覚器プラコードの起源 (2010)
  • Author(s): 佐藤滋
  • Organizer: 日本遺伝学会第82回大会
  • Place of Presentation: 北海道大学高等教育機能開発総合センター、札幌
  • Year and Date: 2010-09-22
• [Presentation] Six1 enhancers as a tool to understand vertebrate sensory organogenesis (2010)
  • Author(s): Sato, S.
  • Organizer: 日本発生生物学会第43回大会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2010-06-21
• [Presentation] 脊椎動物の感覚器形成の初期過程の理解を目指して (2010)
  • Author(s): 佐藤 滋,池田 啓子,塩井 剛,中尾和貴,相沢 慎一,矢嶋 浩,川上 潔
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学教養学部,東京
• [Presentation] Six1 enhancers as a tool to understand vertebrate sensory organogenesis. (2010)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Aizawa S, Yajima H, Kawakami K
  • Organizer: 日本発生生物学会第43回大会
  • Place of Presentation: 国立京都国際会館,京都
• [Remarks]
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks]
  • URL: http://www.jichi.ac.jp/biol/home.html