| Project/Area Number |
22590180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASUTAKA Satoru 金沢医科大学, 医学部, 助教 (30139787)
KOMINAMI Rieko 金沢医科大学, 医学部, 助教 (60163672)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 有尾両生類 / アホロートル / 四肢再生 / 四肢発生 / パターン決定 / Tbx5 / Tbx4 / Pitx1 |
|---|
| Research Abstract |
Urodeles have the ability to regenerate amputated limbs throughout their life span. In the present study, we attempted to elucidate how axolotls can specify limb type correctly during the regeneration process. We misexpressed Tbx5 in regenerating hindlimb blastema, and consequently a forelimb-like hindlimb regenerated from the hindlimb blastema. Therefore, we considered that Tbx5 plays a key role in the specification of forelimb during the regeneration process of axolotl limbs. However, we could not elucidate the factor in specifying forelimb blastema in the present study.
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