| Project/Area Number |
22590182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
WADA Naoyuki 東京理科大学, 理工学部, 准教授 (50267449)
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| Co-Investigator(Kenkyū-buntansha) |
NICHIMATSU Shin-ichiro 川崎医科大学, 医学部, 講師 (20222185)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 顎顔面発生 / 頭蓋底軟骨 / 神経堤細胞 / 発生系譜 / 糖鎖 / 顎顔面形成 / Foxd3 / 梁軟骨 / レクチン / 細胞系譜 / Six2 / 糖蛋白質 |
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| Research Abstract |
In this project, we analyzed the developmental origin of the prechordal chondrocranium, which act as the skull base in the head and midline skeleton in the face, and also investigated molecules that are involved in formation of the chondrocranium. By fate map analysis of cranial neural crest cells, the prechodal cranium is composed from three elements, the paired lateral cartilages, and the single medial cartilage. During medial cartilage formation, Foxd3, a transcription factor which regulates neural crest differentiation, was expressed in precursor cells of the cartilage. In addition, cells in the medial cartilage also expressed a carbohydrate chain, which is detected by peanut lectin (PNA). By contrast, expression of PNA-positive molecules on cells in the lateral cartilage was weak. These results suggest that the cells in the medial cartilage have distinct cellular properties from cells in the lateral cartilage.
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