Histochemical studies on the expression patterns and dynamical changes of carbohydrates
| Project/Area Number |
22590193
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 細胞組織化学 / 糖鎖 / レクチン / 組織細胞化学 / 糖脂質 / 血管内皮 / 癌細胞 / 糖尿病 / 血管内皮細胞 / 組織アレイ / 多重標識 / 糖尿病モデル動物 |
|---|
| Research Abstract |
More than fifty kinds of lectins and sugar-specific monoclonal antibodies were histochemically applied to various kinds of human and mouse tissue specimens. Organ-specific distribution of sugar moieties were demonstrated on both parenchymal cells and vascular endothelial cells. Specific distribution of endothelial cell surface carbohydrates might be an important clue to explain the mechanisms of organ-specific cancer metastasis. Specific distribution of glycolipids were also demonstrated on rat cerebrum, small intestine and kidney under various pathological states including diabetes. Histochemical approaches revealed important aspects of the dynamic changes of sugar expression on various tissues and cells.
|
Report
(4 results)
Research Products
(67 results)
-
[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013
Author(s)
Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
-
Journal Title
Hypertension
Volume: 61
Issue: 2
Pages: 341-351
DOI
Related Report
Peer Reviewed
-
[Journal Article] Vascular Endothelial Adrenomedullin-RAMP2 System 18 Essential for Vascular Integrity and Organ Homeostasis2013
Author(s)
Teruhide Koyama. Laura Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Tbriyama, Ralf H. Adams, Hayato Kawakami, Naoki Mochizuki, Alfredo Martinez, Takayuki Shindo
-
Journal Title
Circulation
Volume: 127
Issue: 7
Pages: 842-853
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice2013
Author(s)
Uemura. Mami., Ozawa A. Nagala T. Kurosawa K., Tsurukawa. K., Nobuhisa I., Taka T. Mara. K., Kudo, A., Kawakami. H., Saijoh. Y. Kurohmaru M. Kanai, Azuma. M., Kanai. Yoshiakira.
-
Journal Title
Development
Volume: 140
Issue: 3
Pages: 639-648
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Destructive effects of butyrate on the cell envelope of Helicobacter pylori2012
Author(s)
Yonezawa H, Osaki T, Hanawa T, Kurata S, Zaman C, Woo TDH, Takahashi M, Matsubara S, Kawakami H, Ochiai K, Kamiya S
-
Journal Title
J Med Microbiol
Volume: 61
Issue: 4
Pages: 582-589
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.2010
Author(s)
Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T.
-
Journal Title
J Biol Chem.
Volume: 285(25)
Issue: 25
Pages: 19193-204
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
