Clarification on the role of semaphorin signal transduction mechanism regulating microglial function in brain homeostasis
| Project/Area Number |
22590195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kenji 名城大学, 薬学部, 助教 (80294122)
TAKEUCHI Noriko 名城大学, 薬学部, 助手 (80076728)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 発生学 / 形態形成学 / セマフォリン / ミクログリア / 脳内ホメオスターシス / プレキシン / 脳内炎症 / 精神疾患 / 細胞分化・組織形成 / 那須-ハコラ病 |
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| Research Abstract |
Plexin-A1 is a receptor of semaphorins originally found as repulsive axon guidance molecules. Plexin-A1 deficient mice over 14-week-old were revealed to have significant deficits in prepulse inhibition of auditory startle reflex which can be also observed in psychiatric disease such as schizophrenia. Plexin-A1 deficient mice also displayed significant increase in locomotion activity and grooming behavior and age-dependent microglial overactivation and demyelination. Thus, plexin-A1 deficient mice is an animal model useful to obtain a novel finding which helps us clarify the pathogenic mechanism of psychiatric diseases recently suggested to be related to abnormal microglia, but still concealing essentially unknown factors.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Scavenger receptors target glycolipids for natural killer T cell activation.2012
Author(s)
Stefan Freigang, Elise Landais, Victoria Zadorozhny, Lisa Kain, Kenji Yoshida, Yang Liu, Shenglou Deng, Wulf Palinski, Paul B. Savage, Albert Bendelac, Luc Teyton
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Journal Title
J. Clin. Invest.
Volume: 122
Pages: 3943-3954
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[Journal Article] Demethylation restores SN38 sensitivity in cells with acquired resistance to SN38 derived from human cervical squamous cancer cells.2011
Author(s)
Tetsuji Tanaka, Tao Bai, Saori Toujima, Tomoko Utsunomiya, Toshihide Matsuoka, Aya Kobayashi, Madoka Yamamoto, Noriyuki Sasaki, Yuko Tanizaki, Hirotoshi Utsunomiya, Junko Tanaka and Kazunori Yukawa
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Journal Title
Oncol Rep.
Volume: 27(4)
Pages: 1292-1298
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