| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
Assembling and analyzing cells’ coordinates during development greatly facilitate understanding of organogenetic dynamics. In this study, video recordings of embryonic heart contractions were subjected to point-tracking analysis, where heart functions and patterns of conduction were deduced. Abnormal conduction was causative of an endocardial cushion defect. NFATc4 is a calcium-dependent transcription factor directly responsible for excitation-transcription coupling within the myocardium. Time-lapse imaging of fluorescently-tagged NFATc4 indicated that normal conduction through gap junctions could efficiently activate NFATc4.
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