Luminal alkalinization attenuates proteinuria-induced oxidativedamage in proximal tubular cells.
| Project/Area Number |
22590199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Michiaki 東北大学, 東北メディカル・メガバンク機構, 准教授 (40400246)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 腎生理学 / 慢性腎臓病 / 尿細管 / 酸・塩基平衡 / 酸化ストレス / 蛋白尿 / 尿アルカリ化 |
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| Research Abstract |
Renal interstitial fibrosis on chronic kidney disease, CKD is derived from reactive oxygen species owing in proximal tubular cells stimulated by proteinuria. Acid circumstance in physiologicaly tubular lumen is not harmful in the kidney, however, the condition increases ROS generated by NAD(P)H oxidase via activation of Pyk2 in CKD with proteinuria. Intraluminal alkalinization with bicabonate is possible to prevent progression of CKD by inhibition of intrarenal ROS generation.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells2011
Author(s)
Souma T, Abe M, Moriguchi T, Takai J, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S
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Journal Title
J Am Soc Nephrol
Volume: 22
Issue: 4
Pages: 635-648
DOI
Related Report
Peer Reviewed
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