| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
Renal interstitial fibrosis on chronic kidney disease, CKD is derived from reactive oxygen species owing in proximal tubular cells stimulated by proteinuria. Acid circumstance in physiologicaly tubular lumen is not harmful in the kidney, however, the condition increases ROS generated by NAD(P)H oxidase via activation of Pyk2 in CKD with proteinuria. Intraluminal alkalinization with bicabonate is possible to prevent progression of CKD by inhibition of intrarenal ROS generation.
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