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Activation mechanism of cyclic ADP-ribose-synthesizing enzyme CD38

Research Project

Project/Area Number 22590202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionKanazawa University

Principal Investigator

MINAKO Hashii  金沢大学, 子どものこころの発達研究センター, 協力研究員 (10272957)

Co-Investigator(Kenkyū-buntansha) HIGUCHI Yoshihiro  鈴鹿医療科学大学, 薬学部, 教授 (10019630)
松川 茂  福井大学, ライフサイエンス支援センター, 准教授 (00092809)
東田 陽博  金沢大学, 医学系, 教授 (30093066)
Co-Investigator(Renkei-kenkyūsha) HIGASHIDA Haruhiro  金沢大学, 医学系, 教授 (30093066)
MATSUKAWA Shigeru  福井大学, 学内共同利用施設 等, 准教授 (00092809)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsCD38 / サイクリックADPリボース / カルシウムイオン / 結合蛋白 / プロテオミクス / cADPリボース / カルシウム / リン酸化 / エピトーグタグ / 免疫沈降
Research Abstract

Human CD38 has enzymatic function that catalyzes multiple reactions to produce Ca2+-mobilizing second messenger, cyclic ADP-ribose. In this study, we try to detect CD38-interacting proteins those may influence CD38 activity using proteomic analysis. We find protein kinase (PK) as a binding partner of CD38, and show that enhanced Ca2+signaling including cytosolic Ca2+oscillations were suppressed by inhibition of PK. Therefore it is suggested that PK is involved in activation mechanism of CD38.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Dopamine-Induced Regulation and Deregulation of the Catabolism of Cyclic ADP-Ribose, an Intrinsic mTOR Signal InhibitorDuring Development in the Rodent Striatum2013

    • Author(s)
      Higashida,C., Islam,M.S., Hashii,M., Higashida,H
    • Journal Title

      Messenger

      Volume: 2 Issue: 1 Pages: 33-43

    • DOI

      10.1166/msr.2013.1019

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular calcium concentrations regulated by cyclic ADP-ribose and heat in the mouse hypothalamus2012

    • Author(s)
      Liu,H.-X., Hashii,M., Higashida,H
    • Journal Title

      Messenger

      Volume: 1 Issue: 2 Pages: 150-159

    • DOI

      10.1166/msr.2012.1015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells results in behavioral recovery in hemiparkinsonian mice2012

    • Author(s)
      Jin,D., Hashii,M., Higashida,H
    • Journal Title

      Neurochem. Int

      Volume: 61 Issue: 6 Pages: 907-912

    • DOI

      10.1016/j.neuint.2011.12.021

    • NAID

      120004966609

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] カルシウム動員セカンドメッセンジャー・サイクリックADPリボースの脳機能における役割、2011

    • Author(s)
      橋井美奈子
    • Journal Title

      金沢大学十全医学会雑誌

      Volume: 120 Pages: 171-176

    • NAID

      10030163961

    • URL

      http://hdl.handle.net/2297/30245

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Missense Mutation in CD38 Associated with Autism Spectrum Disorder in Three Pedigrees.In:Eapen,V.,ed. Autism - ANeurodevelopmental Journey from Genes to Behaviour2011

    • Author(s)
      Higashida, H., Munesue, T., Hashii,M
    • DOI

      10.5772/17774

    • ISBN
      9789533074931
    • Related Report
      2012 Final Research Report
  • [Journal Article] カルシウム動員セカンドメッセンジャー・サイクリックADPリボースの脳機能における役割2011

    • Author(s)
      橋井美奈子
    • Journal Title

      金沢大学十全医学会雑誌

      Volume: 120 Pages: 171-176

    • NAID

      10030163961

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, ParkK, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA,Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, KatoN, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res

      Volume: 67(2) Issue: 2 Pages: 181-91

    • DOI

      10.1016/j.neures.2010.03.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocininduced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice2010

    • Author(s)
      Lopatina,O.,Liu,H.X.,Amina,S., Hashii,M.,Higashida,H
    • Journal Title

      Neuropharmacology

      Volume: 58 Issue: 1 Pages: 50-55

    • DOI

      10.1016/j.neuropharm.2009.06.012

    • NAID

      120001451026

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular calcium elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without exogenous expression of human oxytocin receptors2010

    • Author(s)
      Amina,S.,Hashii,M.,Ma,W.J.,Yokoyama,S.,Lopatina,O.,Liu,H.X.,Islam,M.S.,Higashida,H
    • Journal Title

      J. Neuroendocrinol

      Volume: 22 Issue: 5 Pages: 460-466

    • DOI

      10.1111/j.1365-2826.2010.01978.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular calciuln elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15neuronal cells with or without exogenous expression of human oxytocinreceptors.2010

    • Author(s)
      Amina S, Hashu M, Ma WJ, Yokoyama S, Higashida H, et al.
    • Journal Title

      J.Neuroendocrinol.

      Volume: 22 Pages: 460-466

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose orCa(2+) concentrations is involved in autoregulation of oxytocin secretion in thehypothalamus and posterior pituitary in male mice.2010

    • Author(s)
      Lopatina O, Liu HX, Amina S, Hashii M, Higashida H.
    • Journal Title

      Neuropharmacology

      Volume: 58 Pages: 50-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic vaziants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Hashii M, Higashida H, et al.
    • Journal Title

      Neurosci.Res.

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 合成サイクリックADPリボースアナログ構造の違いによる神経細胞内Ca2+動員効果の比較2011

    • Author(s)
      橋井美奈子、周東智、東田陽博
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光(石川県)
    • Year and Date
      2011-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 合成サイクリックADPリボースアナログ構造の違いによる神経細胞内Ca^<2+>動員効果の比較2011

    • Author(s)
      橋井美奈子, 周東智, 東田陽博
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光(石川県加賀市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reactive-oxygen species-independent chromosomal giant dna fragmentation associated with caspase-mediated apoptosis in ultraviolet-irradiated cells2011

    • Author(s)
      Higuchi Y, Hashii M, Tanii S, Koriyama Y
    • Organizer
      Redox biology and micronutrients : from signaling to translation and back
    • Place of Presentation
      The marmara taksim hotel, Istanbul, Turkey
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイクリックADPリボース合成酵素CD38の細胞移動に対する役割2010

    • Author(s)
      橋井美奈子、サラワト アミナ、オリガロパチナ、東田陽博
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸コンベンションセンター (兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] サイクリックADPリボース合成酵素CD38の細胞移動に対する役割2010

    • Author(s)
      橋井美奈子、サラワトアミナ、オリガロパチナ、東田陽博
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸コンベンションセンター(神戸、兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Book] A Missense Mutation in CD38 Associated with Autism Spectrum Disorder in Three Pedigrees. In : Autism-A Neurodevelopmental Journey from Genes to Behaviour(Eapen V, ed.)2011

    • Author(s)
      Higashida H, Munesue T, Yokoyama S, Hashii M, Koizumi K, Matsushima A
    • Total Pages
      14
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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