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Functional role of the transient receptor potential canonical (TRPC) channels in the development of cardiac ischemia/reperfusion injury

Research Project

Project/Area Number 22590205
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionShiga University of Medical Science

Principal Investigator

MATSUURA Hiroshi  滋賀医科大学, 医学部, 教授 (60238962)

Co-Investigator(Kenkyū-buntansha) KOJIMA Akiko  滋賀医科大学, 医学部, 助教 (50447877)
OMATSU Mariko  滋賀医科大学, 医学部, 准教授 (80161397)
DING Wei-guang  滋賀医科大学, 医学部, 助教 (80242973)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生体膜 / チャネル / トランスポーター / 能動輸送 / 心筋虚血再灌流傷害 / TRPCチャネル / Ca2+過負荷 / 細胞過拘縮 / ランゲンドルフ灌流法 / 2-APB / LaCl3 / 再疎通療法 / 活性酸素種 / 過酸化水素 / 共焦点レーザ顕微鏡 / 細胞内Ca^<2+>イメージング / 過拘縮 / パッチクランプ法 / Ca^<2+>パラドックス / マウス心室筋細胞 / fluo-3 / 虚血再灌流傷害 / Ca^<2+>過負荷
Research Abstract

Ca2+overload has been implicated in the pathogenesis of ischemia/reperfusion injury in the heart. The present investigation used Langendorff perfusion method of mouse hearts and fluorescence Ca2+imaging of mouse ventricular myocytes and revealed that the transient receptor potential canonical (TRPC) channels mediate the Ca2+entry responsible for Ca2+overload during the reperfusion of ischemic myocardium. These observations indicate that TRPC channel blockade could provide potential new avenues to develop strategies for protecting the heart during reperfusion of ischemic myocardium.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (73 results)

All 2013 2012 2011 2010 Other

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (23 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Sevoflurane Protects Ventricular Myocytes against Oxidative Stress-induced Cellular Ca2+Overload and Hypercontracture2013

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Anesthesiology

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irbesartan-mediated AT1receptor blockade attenuates hyposmostic-induced enhancement of IKscurrent and prevents shortening of action potential duration in atrial myocytes2013

    • Author(s)
      Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
    • Journal Title

      J Renin Angiotensin Aldosterone Syst

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic survival and constitutively active autophagy in self-beating atypically- shaped cardiomyocytes (ACMs): characterization of a new subpopulation of heart cells2013

    • Author(s)
      Omatsu-Kanbe M, Matsuura H
    • Journal Title

      J Physiol Sci

      Volume: 63 Pages: 17-29

    • NAID

      10031169584

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic survival and constitutively active autophagy in self-beating atypically-shaped cardiomyocytes (ACMs): Characterization of a new subpopulation of heart cells2013

    • Author(s)
      Omatsu-Kanbe M, Matsuura H
    • Journal Title

      J Physiol Sci

      Volume: 63 Issue: 1 Pages: 17-29

    • DOI

      10.1007/s12576-012-0236-5

    • NAID

      10031169584

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes.2013

    • Author(s)
      Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
    • Journal Title

      J Renin Angiotensin Aldosterone Syst

      Volume: in press Issue: 4 Pages: 1-7

    • DOI

      10.1177/1470320312474855

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane protects ventricular myocytes against oxidative stress-induced cellular Ca2+ overload and hypercontracture.2013

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Anesthesiology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram2012

    • Author(s)
      Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding W-G, Matsuura H, Kurabayashi M, Horie M
    • Journal Title

      Circ J

      Volume: 76 Pages: 2763-2772

    • NAID

      10031126046

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors2012

    • Author(s)
      Kojima A, Matsuura H
    • Journal Title

      Circ J

      Volume: 76 Pages: 2746-2747

    • NAID

      10031126043

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presence of store-operated Ca2+entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane2012

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Br J Anaesth

      Volume: 109 Pages: 352-360

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart2012

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Br J Pharmacol

      Volume: 166 Pages: 2117-2135

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotype Variability in Patients Carrying KCNJ2 Mutations2012

    • Author(s)
      Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
    • Journal Title

      Circ Cardiovasc Genet

      Volume: 5 Pages: 344-353

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method.2012

    • Author(s)
      Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
    • Journal Title

      Pflugers Arch

      Volume: 463 Pages: 649-668

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Clcurrent in rabbit articular chondrocytes2012

    • Author(s)
      Kumagai K, Imai S, Toyoda F, Okumura N, Isoya E, Matsuura H, Matsusue Y
    • Journal Title

      Br J Pharmacol

      Volume: 166 Pages: 702-720

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors2012

    • Author(s)
      Wu J, Ding W-G, Matsuura H, Horie M
    • Journal Title

      Pflugers Arch

      Volume: 463 Pages: 625-633

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GHGKHKNK octapeptide (P-5m) inhibits metastasis of HCCLM3 cell lines via regulation of MMP-2 expression in in vitro and in vivo studies2012

    • Author(s)
      Han X, Yan DM, Zhao XF, Matsuura H, Ding W-G, Li P, Jiang S, Du BR, Du PG, Zhu X
    • Journal Title

      Molecules

      Volume: 17 Pages: 1357-1372

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotype variability in patients carrying KCNJ2 mutations.2012

    • Author(s)
      Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
    • Journal Title

      Circ Cardiovasc Genet

      Volume: 5 Issue: 3 Pages: 344-353

    • DOI

      10.1161/circgenetics.111.962316

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of store-operated Ca2+ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane2012

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H & Nosaka S.
    • Journal Title

      Br J Anaesth

      Volume: 109 Issue: 3 Pages: 352-360

    • DOI

      10.1093/bja/aes212

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors2012

    • Author(s)
      Kojima A, Matsuura H
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 12 Pages: 2746-2747

    • DOI

      10.1253/circj.CJ-12-1297

    • NAID

      10031126043

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE3 T4A as the Genetic Basis of Brugada-Pattern Electrocardiogram2012

    • Author(s)
      Nakajima T, Ashihara T, et al.
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 12 Pages: 2763-2772

    • DOI

      10.1253/circj.CJ-12-0551

    • NAID

      10031126046

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 17β-Estradiol inhibits the doxorubicin-induced apoptosis via block of volume-sensitive Cl− current in rabbit articular chondrocytes.2012

    • Author(s)
      Kumagai K, Imai S, Toyota F, Okumura N, Matsuura H, Matsusue Y.
    • Journal Title

      Br J Pharmacol.

      Volume: 116 Issue: 2 Pages: 702-720

    • DOI

      10.1111/j.1476-5381.2011.01802.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method2012

    • Author(s)
      Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
    • Journal Title

      Pflugers Arch.

      Volume: 463 Issue: 5 Pages: 649-668

    • DOI

      10.1007/s00424-012-1084-0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy is constitutively active in normal mouse sino-atrial nodal cells.2011

    • Author(s)
      Omatsu-Kanbe M, Yamamoto T, Matsuura H
    • Journal Title

      Acta Histochem Cytochem

      Volume: 44 Pages: 223-231

    • NAID

      130000941524

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process2011

    • Author(s)
      Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M
    • Journal Title

      Biochim Biophys Acta

      Volume: 1812 Pages: 1452-1459

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels2011

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Anesthesiology

      Volume: 115 Pages: 509-522

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation2011

    • Author(s)
      Ohno S, Zankov DP, Ding W-G, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 4 Pages: 352-361

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reply to "Letter to the editor: 'Validating the requirement for beat-to-beat coupling of the Ca2+clock and M clock in pacemaker cell normal automaticity'"2011

    • Author(s)
      Himeno Y, Toyoda F, Matsuura H, Noma A
    • Journal Title

      Am J Physiol

      Volume: 300

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability.2011

    • Author(s)
      Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
    • Journal Title

      Circ Res

      Volume: 108 Pages: 458-468

    • NAID

      130002130408

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Minor contribution of cytosolic Ca2+transients to the pacemaker rhythm in guinea pig sinoatrial node cells2011

    • Author(s)
      Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
    • Journal Title

      Am J Physiol

      Volume: 300

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidyl- choline enhances IKscurrents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways.2011

    • Author(s)
      Ding W-G, Toyoda F, Ueyama H, Matsuura H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50 Pages: 58-65

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atrioventricular block-induced Torsades de Pointeswith clinical and molecular backgrounds similar to congenital long QT syndrome2011

    • Author(s)
      Oka Y, Itoh H, Ding W-G, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
    • Journal Title

      Circ J

      Volume: 74 Pages: 2562-2571

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idio pathic ventricular fibrillation2011

    • Author(s)
      Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattri T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 4 Issue: 3 Pages: 352-361

    • DOI

      10.1161/circep.110.959619

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels2011

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M,Matsuura H, Nosaka S
    • Journal Title

      Anesthesiology

      Volume: 115 Issue: 3 Pages: 509-522

    • DOI

      10.1097/aln.0b013e31822b7901

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process2011

    • Author(s)
      Tsuji-Wakisaka K, Ashihara T, et al.
    • Journal Title

      BBA-Molecular Basis of Disease

      Volume: 1812 Issue: 11 Pages: 1452-1459

    • DOI

      10.1016/j.bbadis.2011.07.011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy Is Constitutively Active in Normal Mouse Sino-Atrial Nodal Cells2011

    • Author(s)
      Omatsu-Kanbe M, Yamamoto T, Matsuura H.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 44 Issue: 5 Pages: 223-231

    • DOI

      10.1267/ahc.11030

    • NAID

      130000941524

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidylcholine enhances I_<Ks> currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways.2011

    • Author(s)
      Ding WG, Toyoda F, Ueyama H, Matsuura H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50 Pages: 58-65

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minor contribution of cytosolic Ca^<2+> transients to the pacemaker rhythm in guinea pig sinoatrial node cells.2011

    • Author(s)
      Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
    • Journal Title

      Am J Physiol

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of LQT2 mutant stability.2011

    • Author(s)
      Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai, A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
    • Journal Title

      Circ Res

      Volume: 108 Pages: 458-468

    • NAID

      130002130408

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence and functional role of the rapidly activating delayed rectifier K+current in left and right atria of adult mice.2010

    • Author(s)
      Nakamura H, Ding W-G, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
    • Journal Title

      Eur J Pharmacol

      Volume: 649 Pages: 14-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+paradox injury mediated through TRPC channels in mouse ventricular myocytes2010

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Br J Pharmacol

      Volume: 161 Pages: 1734-1750

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes2010

    • Author(s)
      Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
    • Journal Title

      J Membr Biol

      Volume: 235 Pages: 73-87

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-beating atypically shaped cardiomyocytes survive a long-term postnatal development preserving expression of fetal cardiac genes in mice.2010

    • Author(s)
      Omatsu-Kanbe M, Yamamoto T, Mori Y, Matsuura H
    • Journal Title

      J Histochem Cytochem

      Volume: 58 Pages: 543-551

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.2010

    • Author(s)
      Wu J, Shimizu W, Ding W-G, Ohno S, Toyoda F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M
    • Journal Title

      Heart Rhythm

      Volume: 7 Pages: 199-205

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the rapidly activating delayed rectifier potassium current, 1_<Kr>, in HL-1 mouse atrial myocytes.2010

    • Author(s)
      Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
    • Journal Title

      J Membr Biol

      Volume: 235 Pages: 73-87

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+> paradox injury mediated through TRPC channels in mouse ventricular myocytes.2010

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Journal Title

      Br J Pharmacol

      Volume: 161 Pages: 1734-1750

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence and functional role of the rapidly activating delayed rectifier K^+ current in left and right atria of adult mice.2010

    • Author(s)
      Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
    • Journal Title

      Eur J Pharmacol

      Volume: 649 Pages: 14-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome.2010

    • Author(s)
      Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
    • Journal Title

      Circ J

      Volume: 74 Pages: 2562-2571

    • NAID

      10027424141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Calmodulin potentiates IKs in guinea-pig SA node cells by activating Ca2+/calmodulin-dependent protein kinase II.2013

    • Author(s)
      Xie Y, Ding W-G, Matsuura H.
    • Organizer
      The 90thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] COX-2 selective blocker inhibits the TNF-induced apoptosis in isolated rabbit articular chondrocytes.2013

    • Author(s)
      Kumagai K, Imai S, Toyoda F, Maeda T, Kubo M, Matsuura H, Matsusue Y
    • Organizer
      The 90thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Requirement of autophagy in the development and ischemic tolelenace of self-beating atypically-shaped cardio- myocytes (ACMs), a new subpopulation of heart cells.2013

    • Author(s)
      Omatsu-Kanbe M. Matsuura H
    • Organizer
      The 90thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] The improved effect of hypothermic cultivation on the functional expression of human cardiac Kv1.5 channels2013

    • Author(s)
      Ding W-G, Xie Y, Toyoda F, Bai JY. Matsuura H
    • Organizer
      The 90thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Positive correlation between Istand ICa,Lin guinea-pig sinoatrial node cells2013

    • Author(s)
      Toyoda F, Ding W-G, Matsuura H
    • Organizer
      The 90thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Biophysiocal properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrom2013

    • Author(s)
      Aiba T, Toyoda F, Makita N, Matsuura H, Hagiwara N, Sumitomo N, Kamakura S, Shimizu W
    • Organizer
      American Heart Association Annual Meeting
    • Place of Presentation
      Los Angels, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] 心房筋伸展によるAT1受容体を介した緩徐活性型遅延整流性K+電流(Iks)の増大 -心房細動のAT1受容体遮断薬によるアップストリーム治療のメカニズム-2012

    • Author(s)
      松浦 博,Zankov DP,堀江 稔
    • Organizer
      第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
    • Place of Presentation
      秋田
    • Year and Date
      2012-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 心房筋伸展伸展によるAT_1受容体を介した緩徐活性型遅延整流性K+電流(I_Ks)の増大-心房細動のAT_1受容体遮断薬によるアップストリーム治療のメカニズム-2012

    • Author(s)
      松浦博, Dimnitar P Zankov, 堀江稔
    • Organizer
      第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
    • Place of Presentation
      秋田キャッスルホテル(秋田市)(招待講演)
    • Year and Date
      2012-02-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation2012

    • Author(s)
      Hasegawa K, Ohno S, Itoh H, Hattori T, Makiyama T, Toyoda F, Ding W-G, Chinushi M, Matsuura H, Horie M
    • Organizer
      American Heart Association Annual Meeting
    • Place of Presentation
      Los Angels, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Biophysical properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrome2012

    • Author(s)
      Takeshi Aiba, Futoshi Toyoda, Naomasa Makita, Hiroshi Matsuura, Nobuhisa Hagiwara, Naokata Sumitomo, Shiro Kamakura, and Wataru Shimizu et al
    • Organizer
      American Heart Association Annual Scientific Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation2012

    • Author(s)
      Kanae Hasegawa, Seiko Ohno, Hideki Itoh, Tetuhisa Hattori, Takeru Makiyama, Futoshi Toyoda, Wei-Guang Ding, Masaomi Chinushi, Hiroshi Matsuura, and Minoru Horie
    • Organizer
      American Heart Association Annual Scientific Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes2011

    • Author(s)
      Hoshino S, Nakagawa M, Omatsu- Kanbe M, Matsuura H
    • Organizer
      Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes
    • Place of Presentation
      Granada, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapidly activating delayed rectifier K+current during post-natal development in mouse ventricle2011

    • Author(s)
      Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
    • Organizer
      The 45thAnnual Meeting of Association for European Paediatric Cardiology
    • Place of Presentation
      Granada, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapidly activating delayed rectifier K+ current during post-natal development in mouse ventricle2011

    • Author(s)
      Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
    • Organizer
      The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
    • Place of Presentation
      スペイン
    • Related Report
      2011 Annual Research Report
  • [Presentation] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes2011

    • Author(s)
      Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
    • Organizer
      The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
    • Place of Presentation
      スペイン
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nosaka S. Sevoflurane protects cardiomyocyte from Ca2+paradox by preserving SR Ca2+and blocking TRPC channel2010

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Sevoflurane protects cardiomyocyte from Ca^<2+> paradox by preserving SR Ca 2+ and blocking TRPC channel.2010

    • Author(s)
      Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
    • Organizer
      American Society of Anesthesiologists 2010 Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Post-natal developmental changes in the TRPC channels in mouse heart2010

    • Author(s)
      Hoshino S, Matsuura H, Omatsu-Kanbe M
    • Organizer
      The 87thAnnual Meeting of the Physiological Society of Japa
    • Place of Presentation
      Morioka, Japan
    • Year and Date
      2010-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a ling-term post-natal development whole preserving the expression of fetal cardiac gene in mice2010

    • Author(s)
      Omatsu-Kanbe M, Matsuura H
    • Organizer
      The 87thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Morioka, Japan
    • Year and Date
      2010-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Presence and properties of atypically-shaped cardiomyocyte derived from ventricular tissue of mouse heart2010

    • Author(s)
      Matsuura H, Omatsu-Kanbe M
    • Organizer
      The 87thAnnual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Morioka, Japan
    • Year and Date
      2010-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Presence and properties of atypically-shaped cardiomyocytes derived from ventricular tissue of mouse heart.2010

    • Author(s)
      Matsuura H, Omatsu-Kanbe M
    • Organizer
      J Physiol Sci 60:S18
    • Place of Presentation
      いわて県民情報交流センター(岩手県)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a long-term post-natal development while preserving the expression of fetal cardiac gene in mice.2010

    • Author(s)
      Omatsu-Kanbe M, Matsuura H
    • Organizer
      J Physiol Sci 60:S269
    • Place of Presentation
      いわて県民情報交流センター(岩手県)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Postnatal developmental changes in the TRPC channels in mouse heart.2010

    • Author(s)
      Hoshino S, Matsuura H, Omatsu-Kanbe M
    • Organizer
      J Physiol Sci 60:S119
    • Place of Presentation
      いわて県民情報交流センター(岩手県)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Book] 医系物理学基礎2012

    • Author(s)
      吉田不空雄,松浦 博,森川茂廣
    • Publisher
      三恵社
    • Related Report
      2012 Final Research Report
  • [Remarks] 滋賀医科大学研究情報データベース

    • URL

      http://www.shiga-med.ac.jp/db/index.php

    • Related Report
      2012 Final Research Report
  • [Remarks] 滋賀医科大学研究情報データベース 研究者総覧・研究業績一覧 研究者検索

    • URL

      http://www.shiga-med.ac.jp/db/index.php

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/index.html

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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