Functional role of the transient receptor potential canonical (TRPC) channels in the development of cardiac ischemia/reperfusion injury

• Project/Area Number: 22590205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: MATSUURA Hiroshi 滋賀医科大学, 医学部, 教授 (60238962)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Akiko 滋賀医科大学, 医学部, 助教 (50447877) ; OMATSU Mariko 滋賀医科大学, 医学部, 准教授 (80161397) ; DING Wei-guang 滋賀医科大学, 医学部, 助教 (80242973)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生体膜 / チャネル / トランスポーター / 能動輸送 / 心筋虚血再灌流傷害 / TRPCチャネル / Ca2+過負荷 / 細胞過拘縮 / ランゲンドルフ灌流法 / 2-APB / LaCl3 / 再疎通療法 / 活性酸素種 / 過酸化水素 / 共焦点レーザ顕微鏡 / 細胞内Ca^<2+>イメージング / 過拘縮 / パッチクランプ法 / Ca^<2+>パラドックス / マウス心室筋細胞 / fluo-3 / 虚血再灌流傷害 / Ca^<2+>過負荷

Research Abstract

Ca2+overload has been implicated in the pathogenesis of ischemia/reperfusion injury in the heart. The present investigation used Langendorff perfusion method of mouse hearts and fluorescence Ca2+imaging of mouse ventricular myocytes and revealed that the transient receptor potential canonical (TRPC) channels mediate the Ca2+entry responsible for Ca2+overload during the reperfusion of ischemic myocardium. These observations indicate that TRPC channel blockade could provide potential new avenues to develop strategies for protecting the heart during reperfusion of ischemic myocardium.

Research Products

• [Journal Article] Sevoflurane Protects Ventricular Myocytes against Oxidative Stress-induced Cellular Ca2+Overload and Hypercontracture (2013)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Anesthesiology
  • Peer Reviewed
• [Journal Article] Irbesartan-mediated AT1receptor blockade attenuates hyposmostic-induced enhancement of IKscurrent and prevents shortening of action potential duration in atrial myocytes (2013)
  • Author(s): Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
  • Journal Title: J Renin Angiotensin Aldosterone Syst
  • Peer Reviewed
• [Journal Article] Ischemic survival and constitutively active autophagy in self-beating atypically- shaped cardiomyocytes (ACMs): characterization of a new subpopulation of heart cells (2013)
  • Author(s): Omatsu-Kanbe M, Matsuura H
  • Journal Title: J Physiol Sci Volume: 63 Pages: 17-29
  • NAID: 10031169584
  • Peer Reviewed
• [Journal Article] Ischemic survival and constitutively active autophagy in self-beating atypically-shaped cardiomyocytes (ACMs): Characterization of a new subpopulation of heart cells (2013)
  • Author(s): Omatsu-Kanbe M, Matsuura H
  • Journal Title: J Physiol Sci Volume: 63 Issue: 1 Pages: 17-29
  • DOI: 10.1007/s12576-012-0236-5
  • NAID: 10031169584
  • Peer Reviewed
• [Journal Article] Irbesartan-mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. (2013)
  • Author(s): Wu J, Ding W-G, Zhao J, Zang W-J, Matsuura H, Horie M
  • Journal Title: J Renin Angiotensin Aldosterone Syst Volume: in press Issue: 4 Pages: 1-7
  • DOI: 10.1177/1470320312474855
  • Peer Reviewed
• [Journal Article] Sevoflurane protects ventricular myocytes against oxidative stress-induced cellular Ca2+ overload and hypercontracture. (2013)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Anesthesiology Volume: in press
  • Peer Reviewed
• [Journal Article] KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram (2012)
  • Author(s): Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding W-G, Matsuura H, Kurabayashi M, Horie M
  • Journal Title: Circ J Volume: 76 Pages: 2763-2772
  • NAID: 10031126046
  • Peer Reviewed
• [Journal Article] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors (2012)
  • Author(s): Kojima A, Matsuura H
  • Journal Title: Circ J Volume: 76 Pages: 2746-2747
  • NAID: 10031126043
  • Peer Reviewed
• [Journal Article] Presence of store-operated Ca2+entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane (2012)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Br J Anaesth Volume: 109 Pages: 352-360
  • Peer Reviewed
• [Journal Article] Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart (2012)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Br J Pharmacol Volume: 166 Pages: 2117-2135
  • Peer Reviewed
• [Journal Article] Phenotype Variability in Patients Carrying KCNJ2 Mutations (2012)
  • Author(s): Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
  • Journal Title: Circ Cardiovasc Genet Volume: 5 Pages: 344-353
  • Peer Reviewed
• [Journal Article] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method. (2012)
  • Author(s): Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
  • Journal Title: Pflugers Arch Volume: 463 Pages: 649-668
  • Peer Reviewed
• [Journal Article] 17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Clcurrent in rabbit articular chondrocytes (2012)
  • Author(s): Kumagai K, Imai S, Toyoda F, Okumura N, Isoya E, Matsuura H, Matsusue Y
  • Journal Title: Br J Pharmacol Volume: 166 Pages: 702-720
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors (2012)
  • Author(s): Wu J, Ding W-G, Matsuura H, Horie M
  • Journal Title: Pflugers Arch Volume: 463 Pages: 625-633
  • Peer Reviewed
• [Journal Article] GHGKHKNK octapeptide (P-5m) inhibits metastasis of HCCLM3 cell lines via regulation of MMP-2 expression in in vitro and in vivo studies (2012)
  • Author(s): Han X, Yan DM, Zhao XF, Matsuura H, Ding W-G, Li P, Jiang S, Du BR, Du PG, Zhu X
  • Journal Title: Molecules Volume: 17 Pages: 1357-1372
  • Peer Reviewed
• [Journal Article] Phenotype variability in patients carrying KCNJ2 mutations. (2012)
  • Author(s): Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
  • Journal Title: Circ Cardiovasc Genet Volume: 5 Issue: 3 Pages: 344-353
  • DOI: 10.1161/circgenetics.111.962316
  • Peer Reviewed
• [Journal Article] Presence of store-operated Ca2+ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane (2012)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H & Nosaka S.
  • Journal Title: Br J Anaesth Volume: 109 Issue: 3 Pages: 352-360
  • DOI: 10.1093/bja/aes212
  • Peer Reviewed
• [Journal Article] Electrophysiological Importance of Embryonic Stem Cell-Derived Cardiac Progenitors (2012)
  • Author(s): Kojima A, Matsuura H
  • Journal Title: Circulation Journal Volume: 76 Issue: 12 Pages: 2746-2747
  • DOI: 10.1253/circj.CJ-12-1297
  • NAID: 10031126043
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] KCNE3 T4A as the Genetic Basis of Brugada-Pattern Electrocardiogram (2012)
  • Author(s): Nakajima T, Ashihara T, et al.
  • Journal Title: Circulation Journal Volume: 76 Issue: 12 Pages: 2763-2772
  • DOI: 10.1253/circj.CJ-12-0551
  • NAID: 10031126046
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] 17β-Estradiol inhibits the doxorubicin-induced apoptosis via block of volume-sensitive Cl− current in rabbit articular chondrocytes. (2012)
  • Author(s): Kumagai K, Imai S, Toyota F, Okumura N, Matsuura H, Matsusue Y.
  • Journal Title: Br J Pharmacol. Volume: 116 Issue: 2 Pages: 702-720
  • DOI: 10.1111/j.1476-5381.2011.01802.x
  • Peer Reviewed
• [Journal Article] Postnatal developmental decline in IK1in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method (2012)
  • Author(s): Hoshino S, Omatsu-Kanbe M, Nakagawa M, Matsuura H
  • Journal Title: Pflugers Arch. Volume: 463 Issue: 5 Pages: 649-668
  • DOI: 10.1007/s00424-012-1084-0
  • Peer Reviewed
• [Journal Article] Autophagy is constitutively active in normal mouse sino-atrial nodal cells. (2011)
  • Author(s): Omatsu-Kanbe M, Yamamoto T, Matsuura H
  • Journal Title: Acta Histochem Cytochem Volume: 44 Pages: 223-231
  • NAID: 130000941524
  • Peer Reviewed
• [Journal Article] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process (2011)
  • Author(s): Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M
  • Journal Title: Biochim Biophys Acta Volume: 1812 Pages: 1452-1459
  • Peer Reviewed
• [Journal Article] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels (2011)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Anesthesiology Volume: 115 Pages: 509-522
  • Peer Reviewed
• [Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation (2011)
  • Author(s): Ohno S, Zankov DP, Ding W-G, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 4 Pages: 352-361
  • Peer Reviewed
• [Journal Article] Reply to "Letter to the editor: 'Validating the requirement for beat-to-beat coupling of the Ca2+clock and M clock in pacemaker cell normal automaticity'" (2011)
  • Author(s): Himeno Y, Toyoda F, Matsuura H, Noma A
  • Journal Title: Am J Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. (2011)
  • Author(s): Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
  • Journal Title: Circ Res Volume: 108 Pages: 458-468
  • NAID: 130002130408
  • Peer Reviewed
• [Journal Article] Minor contribution of cytosolic Ca2+transients to the pacemaker rhythm in guinea pig sinoatrial node cells (2011)
  • Author(s): Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
  • Journal Title: Am J Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Lysophosphatidyl- choline enhances IKscurrents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. (2011)
  • Author(s): Ding W-G, Toyoda F, Ueyama H, Matsuura H
  • Journal Title: J Mol Cell Cardiol Volume: 50 Pages: 58-65
  • Peer Reviewed
• [Journal Article] Atrioventricular block-induced Torsades de Pointeswith clinical and molecular backgrounds similar to congenital long QT syndrome (2011)
  • Author(s): Oka Y, Itoh H, Ding W-G, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
  • Journal Title: Circ J Volume: 74 Pages: 2562-2571
  • Peer Reviewed
• [Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idio pathic ventricular fibrillation (2011)
  • Author(s): Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattri T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 4 Issue: 3 Pages: 352-361
  • DOI: 10.1161/circep.110.959619
  • Peer Reviewed
• [Journal Article] Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels (2011)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M,Matsuura H, Nosaka S
  • Journal Title: Anesthesiology Volume: 115 Issue: 3 Pages: 509-522
  • DOI: 10.1097/aln.0b013e31822b7901
  • Peer Reviewed
• [Journal Article] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process (2011)
  • Author(s): Tsuji-Wakisaka K, Ashihara T, et al.
  • Journal Title: BBA-Molecular Basis of Disease Volume: 1812 Issue: 11 Pages: 1452-1459
  • DOI: 10.1016/j.bbadis.2011.07.011
  • Peer Reviewed
• [Journal Article] Autophagy Is Constitutively Active in Normal Mouse Sino-Atrial Nodal Cells (2011)
  • Author(s): Omatsu-Kanbe M, Yamamoto T, Matsuura H.
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 44 Issue: 5 Pages: 223-231
  • DOI: 10.1267/ahc.11030
  • NAID: 130000941524
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine enhances I_<Ks> currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways. (2011)
  • Author(s): Ding WG, Toyoda F, Ueyama H, Matsuura H
  • Journal Title: J Mol Cell Cardiol Volume: 50 Pages: 58-65
  • Peer Reviewed
• [Journal Article] Minor contribution of cytosolic Ca^<2+> transients to the pacemaker rhythm in guinea pig sinoatrial node cells. (2011)
  • Author(s): Himeno Y, Toyoda F, Satoh H, Amano A, Cha CY, Matsuura H, Noma A
  • Journal Title: Am J Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of LQT2 mutant stability. (2011)
  • Author(s): Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai, A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
  • Journal Title: Circ Res Volume: 108 Pages: 458-468
  • NAID: 130002130408
  • Peer Reviewed
• [Journal Article] Presence and functional role of the rapidly activating delayed rectifier K+current in left and right atria of adult mice. (2010)
  • Author(s): Nakamura H, Ding W-G, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
  • Journal Title: Eur J Pharmacol Volume: 649 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Ca2+paradox injury mediated through TRPC channels in mouse ventricular myocytes (2010)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Br J Pharmacol Volume: 161 Pages: 1734-1750
  • Peer Reviewed
• [Journal Article] Characterization of the rapidly activating delayed rectifier potassium current, IKr, in HL-1 mouse atrial myocytes (2010)
  • Author(s): Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
  • Journal Title: J Membr Biol Volume: 235 Pages: 73-87
  • Peer Reviewed
• [Journal Article] Self-beating atypically shaped cardiomyocytes survive a long-term postnatal development preserving expression of fetal cardiac genes in mice. (2010)
  • Author(s): Omatsu-Kanbe M, Yamamoto T, Mori Y, Matsuura H
  • Journal Title: J Histochem Cytochem Volume: 58 Pages: 543-551
  • Peer Reviewed
• [Journal Article] KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders. (2010)
  • Author(s): Wu J, Shimizu W, Ding W-G, Ohno S, Toyoda F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M
  • Journal Title: Heart Rhythm Volume: 7 Pages: 199-205
  • Peer Reviewed
• [Journal Article] Characterization of the rapidly activating delayed rectifier potassium current, 1_<Kr>, in HL-1 mouse atrial myocytes. (2010)
  • Author(s): Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
  • Journal Title: J Membr Biol Volume: 235 Pages: 73-87
  • Peer Reviewed
• [Journal Article] Ca^<2+> paradox injury mediated through TRPC channels in mouse ventricular myocytes. (2010)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Journal Title: Br J Pharmacol Volume: 161 Pages: 1734-1750
  • Peer Reviewed
• [Journal Article] Presence and functional role of the rapidly activating delayed rectifier K^+ current in left and right atria of adult mice. (2010)
  • Author(s): Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H
  • Journal Title: Eur J Pharmacol Volume: 649 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome. (2010)
  • Author(s): Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
  • Journal Title: Circ J Volume: 74 Pages: 2562-2571
  • NAID: 10027424141
  • Peer Reviewed
• [Presentation] Calmodulin potentiates IKs in guinea-pig SA node cells by activating Ca2+/calmodulin-dependent protein kinase II. (2013)
  • Author(s): Xie Y, Ding W-G, Matsuura H.
  • Organizer: The 90thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] COX-2 selective blocker inhibits the TNF-induced apoptosis in isolated rabbit articular chondrocytes. (2013)
  • Author(s): Kumagai K, Imai S, Toyoda F, Maeda T, Kubo M, Matsuura H, Matsusue Y
  • Organizer: The 90thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] Requirement of autophagy in the development and ischemic tolelenace of self-beating atypically-shaped cardio- myocytes (ACMs), a new subpopulation of heart cells. (2013)
  • Author(s): Omatsu-Kanbe M. Matsuura H
  • Organizer: The 90thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] The improved effect of hypothermic cultivation on the functional expression of human cardiac Kv1.5 channels (2013)
  • Author(s): Ding W-G, Xie Y, Toyoda F, Bai JY. Matsuura H
  • Organizer: The 90thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] Positive correlation between Istand ICa,Lin guinea-pig sinoatrial node cells (2013)
  • Author(s): Toyoda F, Ding W-G, Matsuura H
  • Organizer: The 90thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Tokyo, Japan
• [Presentation] Biophysiocal properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrom (2013)
  • Author(s): Aiba T, Toyoda F, Makita N, Matsuura H, Hagiwara N, Sumitomo N, Kamakura S, Shimizu W
  • Organizer: American Heart Association Annual Meeting
  • Place of Presentation: Los Angels, USA.
• [Presentation] 心房筋伸展によるAT1受容体を介した緩徐活性型遅延整流性K+電流(Iks)の増大 -心房細動のAT1受容体遮断薬によるアップストリーム治療のメカニズム- (2012)
  • Author(s): 松浦 博,Zankov DP,堀江 稔
  • Organizer: 第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
  • Place of Presentation: 秋田
  • Year and Date: 2012-02-11
• [Presentation] 心房筋伸展伸展によるAT_1受容体を介した緩徐活性型遅延整流性K+電流(I_Ks)の増大-心房細動のAT_1受容体遮断薬によるアップストリーム治療のメカニズム- (2012)
  • Author(s): 松浦博, Dimnitar P Zankov, 堀江稔
  • Organizer: 第41回日本心脈管作動物質学会,シンポジウム「イオンチャネル研究の最先端」
  • Place of Presentation: 秋田キャッスルホテル(秋田市)(招待講演)
  • Year and Date: 2012-02-11
• [Presentation] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation (2012)
  • Author(s): Hasegawa K, Ohno S, Itoh H, Hattori T, Makiyama T, Toyoda F, Ding W-G, Chinushi M, Matsuura H, Horie M
  • Organizer: American Heart Association Annual Meeting
  • Place of Presentation: Los Angels, USA
• [Presentation] Biophysical properties of Na channel in the S5-S6 high risk LQT3 mutations of the long QT syndrome (2012)
  • Author(s): Takeshi Aiba, Futoshi Toyoda, Naomasa Makita, Hiroshi Matsuura, Nobuhisa Hagiwara, Naokata Sumitomo, Shiro Kamakura, and Wataru Shimizu et al
  • Organizer: American Heart Association Annual Scientific Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation (2012)
  • Author(s): Kanae Hasegawa, Seiko Ohno, Hideki Itoh, Tetuhisa Hattori, Takeru Makiyama, Futoshi Toyoda, Wei-Guang Ding, Masaomi Chinushi, Hiroshi Matsuura, and Minoru Horie
  • Organizer: American Heart Association Annual Scientific Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes (2011)
  • Author(s): Hoshino S, Nakagawa M, Omatsu- Kanbe M, Matsuura H
  • Organizer: Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes
  • Place of Presentation: Granada, Spain
• [Presentation] Rapidly activating delayed rectifier K+current during post-natal development in mouse ventricle (2011)
  • Author(s): Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • Organizer: The 45thAnnual Meeting of Association for European Paediatric Cardiology
  • Place of Presentation: Granada, Spain
• [Presentation] Rapidly activating delayed rectifier K+ current during post-natal development in mouse ventricle (2011)
  • Author(s): Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • Organizer: The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
  • Place of Presentation: スペイン
• [Presentation] Postnatal developmental changes in the TRPC channels in mouse cardiomyocytes (2011)
  • Author(s): Hoshino S, Nakagawa M, Omatsu-Kanbe M, Matsuura H
  • Organizer: The 45^<th> Annual Meeting of Association for European Paediatric Cardiology
  • Place of Presentation: スペイン
• [Presentation] Nosaka S. Sevoflurane protects cardiomyocyte from Ca2+paradox by preserving SR Ca2+and blocking TRPC channel (2010)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-16
• [Presentation] Sevoflurane protects cardiomyocyte from Ca^<2+> paradox by preserving SR Ca 2+ and blocking TRPC channel. (2010)
  • Author(s): Kojima A, Kitagawa H, Omatsu-Kanbe M, Matsuura H, Nosaka S
  • Organizer: American Society of Anesthesiologists 2010 Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-10-16
• [Presentation] Post-natal developmental changes in the TRPC channels in mouse heart (2010)
  • Author(s): Hoshino S, Matsuura H, Omatsu-Kanbe M
  • Organizer: The 87thAnnual Meeting of the Physiological Society of Japa
  • Place of Presentation: Morioka, Japan
  • Year and Date: 2010-05-19
• [Presentation] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a ling-term post-natal development whole preserving the expression of fetal cardiac gene in mice (2010)
  • Author(s): Omatsu-Kanbe M, Matsuura H
  • Organizer: The 87thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka, Japan
  • Year and Date: 2010-05-19
• [Presentation] Presence and properties of atypically-shaped cardiomyocyte derived from ventricular tissue of mouse heart (2010)
  • Author(s): Matsuura H, Omatsu-Kanbe M
  • Organizer: The 87thAnnual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka, Japan
  • Year and Date: 2010-05-19
• [Presentation] Presence and properties of atypically-shaped cardiomyocytes derived from ventricular tissue of mouse heart. (2010)
  • Author(s): Matsuura H, Omatsu-Kanbe M
  • Organizer: J Physiol Sci 60:S18
  • Place of Presentation: いわて県民情報交流センター(岩手県)
  • Year and Date: 2010-05-19
• [Presentation] Self-beating atypically-shaped cardiomyocytes (ACMs) survive a long-term post-natal development while preserving the expression of fetal cardiac gene in mice. (2010)
  • Author(s): Omatsu-Kanbe M, Matsuura H
  • Organizer: J Physiol Sci 60:S269
  • Place of Presentation: いわて県民情報交流センター(岩手県)
  • Year and Date: 2010-05-19
• [Presentation] Postnatal developmental changes in the TRPC channels in mouse heart. (2010)
  • Author(s): Hoshino S, Matsuura H, Omatsu-Kanbe M
  • Organizer: J Physiol Sci 60:S119
  • Place of Presentation: いわて県民情報交流センター(岩手県)
  • Year and Date: 2010-05-19
• [Book] 医系物理学基礎 (2012)
  • Author(s): 吉田不空雄,松浦 博,森川茂廣
  • Publisher: 三恵社
• [Remarks] 滋賀医科大学研究情報データベース
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [Remarks] 滋賀医科大学研究情報データベース 研究者総覧・研究業績一覧 研究者検索
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [Remarks]
  • URL: http://www.shiga-med.ac.jp/index.html