| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Intracellular calcium stores are formed from the endoplasmic reticulum and the nuclear envelope. In the present study, it was revealed in retinal neuroepithelial cells that the membrane potential of the nuclear envelope is altered by the release of calcium from intracellular calcium stores and that synchronous spike discharges are caused by capacitative currents associated with the voltage changes of the nuclear envelope. Moreover, it was found that an extracellular voltage gradient exists in the retinal neuroepithelium. The presence of an endogenous electrical potential gradient was necessary for the correct guidance of retinal ganglion cell axons.
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