| Project/Area Number |
22590219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
MATSUO Osamu 近畿大学, 医学部, 顧問 (40030879)
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| Co-Investigator(Kenkyū-buntansha) |
UESHIMA Shigeru 近畿大学, 農学部, 教授 (30193791)
OKADA Kiyotaka 近畿大学, 医学部, 講師 (20185432)
KAWAO Naoyuki 近畿大学, 医学部, 助教 (70388510)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Nobuyuki 長浜バイオ大学, アニマルバイオサイエンス学科, 教授 (90260281)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血液凝固 / 血液レオロジー / t-PA受容体 / t-PA / 血管内皮細胞 / 組織修復 / 血管 / 蛋白分解活性 / 線溶系 / 血管平滑筋細胞 / t-PAR / ES細胞 |
|---|
| Research Abstract |
t-PAR-transfected endothelial cells enhanced the t-PA binding ability, t-PA-mediated plasminogen activation, migration and invasion of cells, and tube formation as compared with control endothelial cells. Vascular smooth muscle cells bound to t-PA and enhanced t-PA-mediated plasminogen activation. Therefore, it is thought that t-PA/t-PAR system on the membrane surface of these cells plays an important role on the tissue regeneration process.
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