Study on oxidative stress and the metabolism of vitamin C using "mouse having biosynthetic capability of vitamin C"
| Project/Area Number |
22590221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroyuki 金沢大学, 医学系, 教授 (30231476)
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
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| Co-Investigator(Renkei-kenkyūsha) |
HIBINO Yuri 金沢大学, 医学系, 助教 (40362008)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酸化ストレス / ビタミンC / 抗酸化物質 / 生理学 / 栄養学 / デヒドロアスコルビン酸 |
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| Research Abstract |
The changes in plasma ascorbate (AsA) and plasma total antioxidant capacity (TAC) induced by oxidative stress in mouse, which can biosynthesize vitamin C unlike human being, are not fully elucidated. The acute inflammation mouse model and the chronic inflammation mouse model were developed and the change in plasma AsA and plasma TAC were examined using them. The results showed that mouse could increase plasma AsA and plasma TAC against the physiological demand of vitamin C, which was increased by inflammatory reaction, in a short time
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Report
(4 results)
Research Products
(36 results)
