Study on the roles of DEC1 and DEC2 in the rhythmic regulation of lipid metabolism.
| Project/Area Number |
22590223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
NOSHIRO Mitsuhide 広島大学, 大学院・医歯薬保健学研究院, 准教授 (00144858)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 概日リズム / 時計遺伝子 / 脂質代謝 / 脂肪分化 / 核内受容体 / DEC1 / DEC2 / 遺伝子発現 |
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| Research Abstract |
DEC1 and DEC2 are involved in various biological phenomena including clock systems, cell differentiation, and metabolism. I identified novel nuclear receptor response elements, ROR-response elements, in Dec1 and Dec2promoters. I also examined expression of Rorα Dec1, andDec2in differentiating 3T3-L1 adipocytes. The results suggested that RORαsuppresses adipogenicdifferentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1and Dec2expression.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES12012
Author(s)
Ueshima, T., Kawamoto, T., Honda, K.K, Noshiro, M., Fujimoto, K., Nakao, S., Ichinose, N., Hashimoto, S., Gotoh, O., Kato, Y
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Journal Title
Gene
Volume: 510 (2)
Issue: 2
Pages: 118-125
DOI
Related Report
Peer Reviewed
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[Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells2011
Author(s)
Wu, Y., Sato, F., Kawamoto, T., Fujimoto, K., Noshiro, M., (他4名)
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Journal Title
Int J Mol Med
Volume: 27
Issue: 4
Pages: 491-495
DOI
Related Report
Peer Reviewed
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[Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells.2011
Author(s)
Wu, Y., Sato, F., Noshiro, M., Kato, Y., Kijima, H., et al.
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Journal Title
Int J Mol Med
Volume: 27
Pages: 491-495
Related Report
Peer Reviewed
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[Journal Article] Anti-apoptotic effect of the basic helix-loop-helix(bHLH) transcription factor DEC2 in human breast cancer cells.2010
Author(s)
Liu, Y., Sato, F., Noshiro, M., Kato, Y., Kijima, H., et al.
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Journal Title
Genes to Cells
Volume: 15
Pages: 315-325
Related Report
Peer Reviewed
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