Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
DEC1 and DEC2 are involved in various biological phenomena including clock systems, cell differentiation, and metabolism. I identified novel nuclear receptor response elements, ROR-response elements, in Dec1 and Dec2promoters. I also examined expression of Rorα Dec1, andDec2in differentiating 3T3-L1 adipocytes. The results suggested that RORαsuppresses adipogenicdifferentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1and Dec2expression.
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