| Project/Area Number |
22590227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tenshi College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 褐色脂肪組織 / エネルギー消費 / 寒冷刺激 / 肥満 / FDG-PET / カプシノイド / 褐色脂肪 / ネルギー消費 / 加齢 / 体温調節 |
|---|
| Research Abstract |
Brown adipose tissue (BAT), a site of metabolic thermogenesis, is known in small rodents to contribute to the regulation of body temperature, whole-body energy expenditure, and body fat. We have established that human BAT can be identified and assessed by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). In this study, we demonstrated that BAT of healthy adult volunteers was activated by acute cold exposure, in parallel with an increase in whole-body energy expenditure. BAT activity was decreased with age, being inversely related to body fat content. In addition to cold stimulation, non-pungent capsaicin analogs (capsinoids) also activated BAT via a transient receptor potential channel (TRP), leading a reduction of body fat.In conclusion, human BAT contributes to the regulation of energy expenditure and body fat content, and thereby is a hopeful therapeutic target to combat obesity.
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