Human brown adipose tissue: activation by cold stimulation and energy expenditure
| Project/Area Number |
22590227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tenshi College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 褐色脂肪組織 / エネルギー消費 / 寒冷刺激 / 肥満 / FDG-PET / カプシノイド / 褐色脂肪 / ネルギー消費 / 加齢 / 体温調節 |
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| Research Abstract |
Brown adipose tissue (BAT), a site of metabolic thermogenesis, is known in small rodents to contribute to the regulation of body temperature, whole-body energy expenditure, and body fat. We have established that human BAT can be identified and assessed by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). In this study, we demonstrated that BAT of healthy adult volunteers was activated by acute cold exposure, in parallel with an increase in whole-body energy expenditure. BAT activity was decreased with age, being inversely related to body fat content. In addition to cold stimulation, non-pungent capsaicin analogs (capsinoids) also activated BAT via a transient receptor potential channel (TRP), leading a reduction of body fat.In conclusion, human BAT contributes to the regulation of energy expenditure and body fat content, and thereby is a hopeful therapeutic target to combat obesity.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer2012
Author(s)
Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, You A, Kubota K, Saito M, Saeki K
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Journal Title
Cell Metab
Volume: 16
Pages: 394-406
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[Journal Article] Deficient of a clock gene, brain and muscle arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation2011
Author(s)
Shimba S, Ogawa T, Hitosugi S, Ichihashi Y, Nakadaira Y, Kobayashi M, Tezuka M, Kosuge Y, Ishige K, Ito Y, Komiyama K, Okamatsu-Ogura Y, Kimura K, Saito M
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Peer Reviewed
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