| Project/Area Number |
22590233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Hiroshi 鶴見大学, 歯学部, 教授 (10186124)
NISHI Yoshihiro 久留米大学, 医学部, 講師 (20352122)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Fumi
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | グレリン、 / ドーパミン、 / オピオイド、 / 腹側被蓋野 / 側坐核 / マイクロダイアリシス / 摂食 / 報酬 / グレリン / ドーパミン / オピオイド / 食嗜好 / オピオイド受容体 |
|---|
| Research Abstract |
This study investigated the involvement of interaction between food reward and opioid receptor pathways in the effect of ghrelin on the reward-related mesolimbic dopamine neurons. The results showed that ghrelin modulates the mesolimbic dopamine neurons by different opioid neural pathways depending on food reward. The activation of kappa opioid receptor pathway, which does not mediate the effect of food restriction-induced food consumption on the mesolimbic dopamine neurons was distinctive in the effect of ghrelin on the mesolimbic dopamine neurons.
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