Effects of Neuropeptide W, and B on autonomic nervous system

• Project/Area Number: 22590236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: University of Tsukuba
• Principal Investigator: IRUKAYAMA Yoko 筑波大学, 分子行動科学研究コア, 研究員 (90312834)
• Co-Investigator(Kenkyū-buntansha): MURAKOSHI Nobuyuki 筑波大学, 医学医療系, 講師 (80447218) ; SAKURAI Takeshi 金沢大学, 医学系, 教授 (60251055)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生理活性 / ストレス / 循環器 / 高血圧 / 循環器・高血圧

Research Abstract

In this study, we analyzed of the neuropeptide W (NPW) its receptor(NPBWR1), in autonomic functional regulation under stress, using NPB/WR1 deficient (Npbwr-/-) mice. The urinary catecholamines amount of Npbwr-/- mice was increased. To elucidate the role of NPW-NPBWR1 on acute stress, we created a stress model after having contact with the intruder, C57/BL6J mice for 30 minutes. We monitored heart rate, activity, and body temperature using a telemetry system. In Npbwr1-/- mice, recovery to the steady state of the heart rate after contact with the intruder was very slow compared with wild type mice. In Npbwr-/- mice, cardiac hypertrophy was increased in comparison with wild-type mice. After administration of angiotensin II to Npbwr-/- mice, the cardiac hypertrophy deteriorated significantly as compared with wild-type mice.

Research Products

• [Journal Article] A Single Nucleotide Polymorphism of the Neuropeptide B/W receptor-1 GeneInfluences the Evaluation of Facial Expressions (2012)
  • Author(s): Noriya Watanabe, Mari Wada, Yo ko Irukayama-Tomobe, Yousuke Ogata, Natsuko Tujino, Mika Suzuki, Naoki Furutani, Takeshi Sakurai, and Masashi Yanagisawa et.
  • Journal Title: PLoS ONE Volume: Vol. 7 issue 4 Pages: 1-10
  • Peer Reviewed
• [Journal Article] A Single Nucleotide Polymorphism of the Neuropeptide B/W receptor-1 GeneInfluences the Evaluation of Facial Expressions (2012)
  • Author(s): Noriya Watanabe, Mari Wada, Yoko Irukayama-Tomobe, et.al.
  • Journal Title: PLoS ONE Volume: Volume 7 issue 4 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Critical role of neuropeptide B/W receptor 1 signaling in social behaviorand fear memory (2011)
  • Author(s): Ruby Nagata-Kuroiwa, Naoki Furutani, Junko Hara, Mari Hondo, Makoto Ishii, Tomomi Abe, Michihiro Mieda, Natsuko Tsujino, Toshiyuki Motoike, Yuchio Yanagawa, Tomoyuki Kuwaki, Miyuki Yamamoto, Masashi Yanagisawa, and Takeshi Sakurai.
  • Journal Title: PLoS ONE Volume: Vol.6 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Critical role of neuropeptide B/W receptor 1 signahng in social behaviorand fear memory. (2011)
  • Author(s): Nagata-Kuroiwa, R, et. al.
  • Journal Title: PLoS ONE Volume: Vol.6 Pages: 1-12
  • Peer Reviewed