| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The chronic persistent atrial fibrillation model was developedfirst. The complete atrioventricular block was produced to the beagle, the left atrium was equipped with the pacing electrode, and electric stimulus generating equipment was embedded at the right buttock subcutaneous part. Chronic persistent atrial fibrillation was induced by performing an electric stimulus (600 bpm) of an atrium for four weeks. Next, the existing drugs (pilsicainide, disopyramide, aprindine, cibenzoline), an I_Kurblocking agent (AVE0118), and oseltamivir were evaluated in this model. It became clear that oseltamivir has more potent antiarrhythmic effect than the existing anti-atrial fibrillation drugs.
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