Pharmacological study on the association between pain and emotional stress in cancer chemotherapy
Project/Area Number |
22590242
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | ストレス / オキサリプラチン / 末梢神経障害 / 機械的アロディニア / うつ / CaMKII / 三環系抗うつ薬 |
Research Abstract |
The emotional stress enhanced the peripheral neuropathic pain induced by oxaliplatin, a chemotherapeutic agent, in this study. Therefore, psychological pressure may enhance the anticancer drugs-induced pain in cancer patients. We also found that both antidepressant amitriptyline and antipsychotic drug trifluoperazine alleviateanticancer drugs-induced pain by the attenuation of factors related to the onset of neuropathic pain in animal model.
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Report
(4 results)
Research Products
(36 results)