Functional roles of SIRT1 in the differentiation of neural cells
| Project/Area Number |
22590245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Takashi 札幌医科大学, 医学部, 助教 (90457698)
KUNO Atsushi 札幌医科大学, 医学部, 助教 (30468079)
KUNIMOTO Risa 札幌医科大学, 医学部, 助教 (20468094)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サーチュイン / 長寿遺伝子 / 細胞移動 / SIRT1 / neurite / lamellipodia / 神経細胞 / メラノーマ細胞 / PIP3 / Notch / deacetylase / 神経堤 / メラノーマ / p300 / ユビキチン化 / 分化 / NAD / resveratrol / PC12 / NGF |
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| Research Abstract |
We found that SIRT1, an homologue of yeast longevity gene Sir2, bound and deacetylated p300, a co-activator for Notch-intracellular domain, resulting in the ubiquitination and degradation of p300. We found that SIRT1 promoted neurite formation and extension ofPC12 pheochromocytoma cells. We also found that SIRT1 was necessary for lamellipodium formation and migration of B16F1 melanoma cells. Because melanoma cells are derived from neural crest cells, similar mechanism may regulate neural cell migration.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of -catenin2012
Author(s)
Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH
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Journal Title
Biochem Biophys Res Commun
Volume: 423
Pages: 270-275
Related Report
Peer Reviewed
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[Journal Article] Hepatitis B virus X(HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase2012
Author(s)
Srisuttee R, Koh SS, Kim SJ, Malilas W, Boonying W, Cho IR, Jhun BH, Ito M, Horio Y,Seto E, Oh S, Chung YH
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Journal Title
Oncol Rep
Volume: 28
Pages: 276-282
Related Report
Peer Reviewed
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[Journal Article] Longevity-relevant regulation of autophagy at the level of the acetylproteome2011
Author(s)
Marino G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G
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Journal Title
Autophagy
Volume: 7
Pages: 647-649
Related Report
Peer Reviewed
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[Journal Article] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome2011
Author(s)
Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G
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Journal Title
J. Cell Biol
Volume: 192
Pages: 615-629
Related Report
Peer Reviewed
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