Development of cancer therapeutic agents targeting choline transporter
| Project/Area Number |
22590248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
INAZU Masato 東京医科大学, 医学部, 准教授 (00297269)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIMA Hirohisa 東京医科大学, 医学部, 助教 (50306833)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Tomoko 東京医科大学, 医学部, 助手 (20468648)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | トランスポーター / コリン / 癌 / 細胞増殖 / 小細胞肺癌 / アポトーシス / 神経芽腫細胞 / アセチルコリン / フォスファチジルコリン |
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| Research Abstract |
Choline is essential for the synthesis of major membrane phospholipid phosphatidylcholine and neurotransmitter acetylcholine. Elevated levels of choline and up-regulated choline kinase activity have been detected in cancer cells. We found that choline transporter-like proteins (CTLs) are highly expressed in various cancer cells and are also involved in abnormal proliferation. Furthermore, the functional inhibition of CTLs could promote apoptotic cell death. Identification of this new CTLs-mediated choline transport system provides a potential new target for therapeutic intervention.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Mutation of the Mg^(2+) Transporter SLC41A1 Results in a Nephronophthisis-Like Phenotype.2013
Author(s)
Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, Yamada H, Halbritter J, Seki G, Konishi M, Zhou W, Yamane T, Murakami S, Caridi G, Ghiggeri G, Abe T, Hildebrandt F
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Journal Title
J Am Soc Nephrol.
Volume: 24
Issue: 6
Pages: 967-977
DOI
Related Report
Peer Reviewed
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