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Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease

Research Project

Project/Area Number 22590250
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionFujita Health University

Principal Investigator

SUMI-ICHINOSE Chiho  藤田保健衛生大学, 医学部, 准教授 (10247653)

Co-Investigator(Renkei-kenkyūsha) KONDO Kazunao  藤田保健衛生大学, 医学部, 教授 (90270983)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords生理活性物質 / テトラヒドロビオプテリン / チロシン水酸化酵素 / 一酸化窒素合成酵素 / ドパミン神経 / 血管内皮細胞 / ジストニア / フェニルアラニン
Research Abstract

Biopterin content in the brains of Pts-/-DPS mice was fewer than that of wild type mice. The amount of dopamine in the brains of wild type mice increased according to the date after birth, however, that of Pts-/-DPS mice did not. Serotonin content in the brains of Pts-/- mice decreased by P7. The amount of tyrosine hydroxylase protein in the brains of wild type mice increased according to the date after birth. On the contrary, that in the Pts-/-DPS brains did not. Phenylalanine content in the brains of Pts-/-DPS mice dramatically increased between P0 and P7.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2013 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (21 results)

  • [Journal Article] Recovery of neurogenic amines in phenylketonuria micefollowing liver-targeted gene therapy.2012

    • Author(s)
      Hiroya Yagi, Sho Sanechika, Sho Shimaguchi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroaki Mizukami, Masashi Urabe, Hiromi Hamada, Hiroyuki Yoshikawa,Keiya Ozawa, Akihiro Kume.
    • Journal Title

      Neuroreport

      Volume: 23(1) Pages: 30-34

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.2011

    • Author(s)
      Hirofumi Tokuoka, Shin-ichi Muramatsu, Chiho Sumi-Ichinose, Hiroaki Sakane, Masayo Kojima, Yoshinori Aso, Takahide Nomura, Daniel Metzger, and Hiroshi Ichinose.
    • Journal Title

      J Biol Chem

      Volume: 286 (50) Pages: 43549-43558

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cilostazol Inhibits Cytokine-induced Tetrahydrobiopterin Biosynthesis in Human Umbilical Vein Endothelial Cells.2011

    • Author(s)
      Hiroaki Shiraishi, Kazuhisa Ikemoto, Shin Tada, Yasuhiro Udagawa, Masatsugu, Ohtsuki, Chiho Sumi-Ichinose, Kazunao Kondo, and Takahide Nomura.
    • Journal Title

      J Ather Thromb

      Volume: 18(4) Pages: 312-317

    • NAID

      130004845370

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.2011

    • Author(s)
      Daigo Homma, Chiho Sumi-Ichinose, Hirofumi Tokuoka, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo, Setsuko Katoh, and Hiroshi Ichinose.
    • Journal Title

      J Biol Chem

      Volume: 286(2) Pages: 1445-1452

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.2011

    • Author(s)
      Daigo Homma, et al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Pages: 1445-1452

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010

    • Author(s)
      Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo.
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 17-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010

    • Author(s)
      Chiho Sumi-Ichinose, et al.
    • Journal Title

      Journal of Pharmacological Science

      Volume: 114 Pages: 14-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス全血におけるテトラヒ ドロビオプテリンの抗血小板作用2013

    • Author(s)
      菅沼由唯、池本和久、一瀬千穂、野村隆 英、近藤一直
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス血小板凝集にテトラヒドロビオプテリンが及ぼす影響2012

    • Author(s)
      菅沼 由唯、池本 和久、一瀬千穂、野 村 隆英、近藤一直
    • Organizer
      第22回循環器薬理学会年会
    • Place of Presentation
      富山
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] テトラヒドロビオプテリンに よる血小板凝集抑制効果のメカニズム解明2012

    • Author(s)
      菅沼由唯、池本和久、一瀬千穂、野村隆 英、近藤一直
    • Organizer
      第122回日本薬理学会近畿部会
    • Place of Presentation
      豊中
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] チロシン水酸化酵素の転写促進因子 V-1 はドーパ脱炭酸酵素の遺伝子発現を増強する2012

    • Author(s)
      来 延新、川畑伊知郎、一瀬千穂、近藤 一直、加藤成樹、一瀬宏、小林和人、山國徹
    • Organizer
      第51回日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Year and Date
      2012-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] テトラヒドロビオプテリンがマウス血小板凝集に及ぼす影響2012

    • Author(s)
      菅沼由唯、池本和久、一瀬千穂、野村隆 英、近藤一直
    • Organizer
      第121回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] テトラヒドロビオプテリンの欠乏はモノアミン神経系の生後発達を阻害する2012

    • Author(s)
      一瀬(鷲見)千穂, ほか4名
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chiho Sumi-Ichinose, Takahide Nomura, Daniel Metzger.2012

    • Author(s)
      Hiroshi Ichinose, Hirofumi Tokuoka,Shin-ichi Muramatsu
    • Organizer
      Regulation of dopamine contein in the striatum after ablation of the tyrosine hydroxylase gene in the substantia nigra. 10th International Catecholamine Symposium.
    • Place of Presentation
      Asilomar,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of dihydropteridine reductase knockout mice15th2012

    • Author(s)
      Hiroshi Ichinose, Sho Sanechika, Yoshitaka Hara, Yusuke Sudo, Feng Xu, Shun-ichiro Honda, Sho Shimaguchi, Shigeki Matsuki, Mieko Horiguchi, MasayoKojima, Takahide Nomura, Kazunao Kondo, Chiho Sumi-Ichinose.
    • Organizer
      International Symposium onPteridines and Folates
    • Place of Presentation
      Antalya Turkey
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム 1 ビタミン研究の最前線2012

    • Author(s)
      一瀬宏、本間大悟、一瀬(鷲見)千穂、 近藤一直
    • Organizer
      ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連第10回日本機能性食品医用学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Disturbance in the biosynthesis of monoamines andPTSD-like phenotype in the dihydrpterinr reductase-deficient mice.2012

    • Author(s)
      Hiroshi Ichinose, Yusuke Sudo, ShoSanechika, Koichi Tanda, Kenzo Takao, Yoshitaka Hara, Shun-ichiro Honda, Sho Shimaguchi, Masayo Kojima, ChihoSumi-Ichinose, Takahide Nomura, KazunaoKondo, Tsuyoshi Miyakawa
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] テトラヒドロビオプテ リンの欠乏はモノアミン神経系の生後発達 を阻害する2012

    • Author(s)
      一瀬(鷲見)千穂、菅沼由唯、池本和久、 野村隆英、近藤一直
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of dihydropteridine reductase knockout mice.2012

    • Author(s)
      Hiroshi Ichinose
    • Organizer
      15th International Symposium on Pteridines and Folates
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of dopamine contein in the striatum after ablation of the tyrosine hydroxylase gene in the substantia nigra.2012

    • Author(s)
      Hiroshi Ichinose
    • Organizer
      10th International Catecholamine Symposium
    • Place of Presentation
      Asilomar, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hiroshi Ichinose2012

    • Author(s)
      Disturbance in the biosynthesis of monoamines and PTSD-like phenotype in the dihydrpterinr reductase-deficient mice.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一瀬宏2012

    • Author(s)
      ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連
    • Organizer
      第10回日本機能性食品医用学会総会 シンポジウム1 ビタミン研究の最前線
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system2011

    • Author(s)
      D. Homma, C. Sumi-Ichinose, H. Tokuoka, K. Ikemoto, T. Nomura, K. Kondo, H. Ichinose
    • Organizer
      10th International Conference on Alzheimer's and Parkinson's Diseases
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] Tetrahydrobiopterin and reactive oxygen species in cutokine-stimulated HUVEC2011

    • Author(s)
      K. Ikemoto, C. Sumi-Ichinose, T. Nomura, K. Kondo
    • Organizer
      Gordon Research Conference, Vascular Cell Biology
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuronal activity of the basal ganglia in a transgenic mouse model of dopa-responsive dystonia.2011

    • Author(s)
      Satomi Chiken, Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazunao Kondo, Atsushi Nambu
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] テトラヒドロビオプテリン欠損マウスの生後発達と生化学的変化2010

    • Author(s)
      一瀬(鷲見)千穂、池本和久、野村隆英、 近藤一直
    • Organizer
      第118回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-19
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] プテリン類の分析に関する 3 項目の検討2010

    • Author(s)
      池本和久、一瀬千穂、野村隆英、近藤一 直
    • Organizer
      第24回日本プテリジン研究会シンポジウ ム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合 失調症様行動異常を呈する APC1638T マウス の脳におけるモノアミンの動態2010

    • Author(s)
      千田隆夫、尾之内高慶、唐沢延幸、一瀬 千穂、高雄啓三、近藤一直、宮川 剛
    • Organizer
      日本解剖学会第70回中部支部学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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