Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
| Project/Area Number |
22590250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Kazunao 藤田保健衛生大学, 医学部, 教授 (90270983)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生理活性物質 / テトラヒドロビオプテリン / チロシン水酸化酵素 / 一酸化窒素合成酵素 / ドパミン神経 / 血管内皮細胞 / ジストニア / フェニルアラニン |
|---|
| Research Abstract |
Biopterin content in the brains of Pts-/-DPS mice was fewer than that of wild type mice. The amount of dopamine in the brains of wild type mice increased according to the date after birth, however, that of Pts-/-DPS mice did not. Serotonin content in the brains of Pts-/- mice decreased by P7. The amount of tyrosine hydroxylase protein in the brains of wild type mice increased according to the date after birth. On the contrary, that in the Pts-/-DPS brains did not. Phenylalanine content in the brains of Pts-/-DPS mice dramatically increased between P0 and P7.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Recovery of neurogenic amines in phenylketonuria micefollowing liver-targeted gene therapy.2012
Author(s)
Hiroya Yagi, Sho Sanechika, Sho Shimaguchi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroaki Mizukami, Masashi Urabe, Hiromi Hamada, Hiroyuki Yoshikawa,Keiya Ozawa, Akihiro Kume.
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Journal Title
Neuroreport
Volume: 23(1)
Pages: 30-34
Related Report
Peer Reviewed
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[Presentation] Characterization of dihydropteridine reductase knockout mice15th2012
Author(s)
Hiroshi Ichinose, Sho Sanechika, Yoshitaka Hara, Yusuke Sudo, Feng Xu, Shun-ichiro Honda, Sho Shimaguchi, Shigeki Matsuki, Mieko Horiguchi, MasayoKojima, Takahide Nomura, Kazunao Kondo, Chiho Sumi-Ichinose.
Organizer
International Symposium onPteridines and Folates
Place of Presentation
Antalya Turkey
Related Report
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[Presentation] Disturbance in the biosynthesis of monoamines andPTSD-like phenotype in the dihydrpterinr reductase-deficient mice.2012
Author(s)
Hiroshi Ichinose, Yusuke Sudo, ShoSanechika, Koichi Tanda, Kenzo Takao, Yoshitaka Hara, Shun-ichiro Honda, Sho Shimaguchi, Masayo Kojima, ChihoSumi-Ichinose, Takahide Nomura, KazunaoKondo, Tsuyoshi Miyakawa
Organizer
第35回日本神経科学大会
Place of Presentation
名古屋
Related Report
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