Physiological role of calcium transport system regulated by phosphatidylinositol
| Project/Area Number |
22590254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
KITA Satomi 福岡大学, 医学部, 講師 (10461500)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Shintaro 福岡大学, 医学部, 准教授 (40336110)
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| Co-Investigator(Renkei-kenkyūsha) |
IYODA Takuya 福岡大学, 医学部, 助教 (80465715)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脂質キナーゼ / 血管リモデリング / 脂質代謝異常 / シグナル伝達 / 薬理学 |
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| Research Abstract |
To clarify the role of NCX1 and TRPC3 in cardiovascular diseases (hypertension, arteriosclerosis), we generated TRPC3-transgenic (Tg) mice by overexpressing the wild-type and dominant negative TRPC3 using the smooth muscle α-actin promoter. Using these mice, we showed that NCX1 and TRPC3 may predominantly play an important role in α 1-adrenoreceptor agonist-induced vascular responses and blood pressure regulation. Furthermore, we found that blood recovery after unilateral hindlimb ischemia was significantly augmented in NCX1+/- mice compared with that in wild-type mice, suggesting that NCX1 is involved in ischemia-induced angiogenesis.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice2012
Author(s)
Morimoto N, Kita S, Shimazawa M, Namimatsu H, Tsuruma K, Hayakawa K, Mishima K, Egashira N, Iyoda T, Horie I, Gotoh Y, Iwasaki K, Fujiwara M, Matsuda T, Baba A, Komuro I, Horie K, Takeda J, Iwamoto T, Hara H.
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Journal Title
Biochem Biophys Res Commun.
Volume: 429(3-4)
Pages: 186-190
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.2012
Author(s)
Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.
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Journal Title
Clin Exp Nephrol.
Volume: 16(4)
Pages: 530-538
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance2011
Author(s)
Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
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Journal Title
Cell Metabolism
Volume: 14
Pages: 231-241
DOI
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Protein kinase A-mediated phosphorylation of TRPC6 channels underlies suppression of angiotensin II-induced vasoconstriction.2011
Author(s)
Nishioka K, Nishida M, Ariyoshi M, Saiki S, Jian Z, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H
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Journal Title
Arterioscler. Thromb. Vasc. Biol.
Volume: 31
Pages: 2278-2286
DOI
Related Report
Peer Reviewed
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