Biological analyses of scavenger receptor CL-P1 which is a host defense factor
| Project/Area Number |
22590259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010-10-20 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 発生・分化 / コレクチン / スカベンジャー受容体 / 血管内皮細胞 / ノックアウトマウス / トランスジェニックマウス / 胎生致死 / 自然免疫 |
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| Research Abstract |
I have been working for the elucidation of the role in the biological and developmental processes of CL-P1. Since the CL-P1 gene knockout mice are embryonic lethal, I examined the lethal time, it was clarified that it is pre-implantation. I have studied a function of CL-P1 after the fertilization using the transgenic mouse which developed GFP by the promoter of the CL-P1 gene, but I was able to confirm the expression from immediately after fertilization, but it was not possible to clarify whether play what function. And creating conditional knockout mice in order to analyze the role in vivo, it was examined, but did not provide a new finding at the present stage. I continue examining it and would like to try for the elucidation of the biological CL-P1 in future.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment2011
Author(s)
Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang S-J, Hasebe N, KikuchiK, Itabe H, Yoshida I, Suzuki Y, Wakamiya N.
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Journal Title
Biochimica et Biophysica Acta
Volume: 1810
Issue: 9
Pages: 836-842
DOI
Related Report
Peer Reviewed
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