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Biological analyses of scavenger receptor CL-P1 which is a host defense factor

Research Project

Project/Area Number 22590259
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionAsahikawa Medical College

Principal Investigator

OHTANI Katsuki  旭川医科大学, 医学部, 准教授 (90396367)

Project Period (FY) 2010-10-20 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords発生・分化 / コレクチン / スカベンジャー受容体 / 血管内皮細胞 / ノックアウトマウス / トランスジェニックマウス / 胎生致死 / 自然免疫
Research Abstract

I have been working for the elucidation of the role in the biological and developmental processes of CL-P1. Since the CL-P1 gene knockout mice are embryonic lethal, I examined the lethal time, it was clarified that it is pre-implantation. I have studied a function of CL-P1 after the fertilization using the transgenic mouse which developed GFP by the promoter of the CL-P1 gene, but I was able to confirm the expression from immediately after fertilization, but it was not possible to clarify whether play what function. And creating conditional knockout mice in order to analyze the role in vivo, it was examined, but did not provide a new finding at the present stage. I continue examining it and would like to try for the elucidation of the biological CL-P1 in future.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (37 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (24 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC)2014

    • Author(s)
      Takahashi K, Ohtani K, Larvie M, Moyo P, Chigweshe L, Van Cott EM, Wakamiya N
    • Journal Title

      J Thromb Thrombolysis

      Volume: 38 Issue: 3 Pages: 331-338

    • DOI

      10.1007/s11239-013-1042-5

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel collectins play double roles in embryonic and fetal development as well as innate immunity2013

    • Author(s)
      Ohtani K, Wakamiya N
    • Journal Title

      Seikagaku

      Volume: Vol85、No. 1 Pages: 38-42

    • NAID

      10031146008

    • URL

      http://www.jbsoc.or.jp/seika/wp-content/uploads/2013/06/85-01-08.pdf

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential cell-protective function of two resveratrol (trans-3,5,4'- trihydroxystilbene) glucosides against oxidative stress2013

    • Author(s)
      Hosoda R, Kuno A, Hori Y, Ohtani K,Wakamiya N, Oohiro A, Hamada H, Horio Y.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 344(1) Issue: 1 Pages: 124-32

    • DOI

      10.1124/jpet.112.198937

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological functions of the novel collectins CL-L1, CL-K1, and CL-P12012

    • Author(s)
      Ohtani, K., Suzuki, Y., Wakamiya, N.
    • Journal Title

      J Biomedicine and Biotechnology

      Volume: 2012 Pages: 1-8

    • DOI

      10.1155/2012/493945

    • NAID

      120005828838

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparisonof human blood concentrations of Collectin Kidney 1 (CL-K1) and Mannan-binding lectin (MBL)2012

    • Author(s)
      Yoshizaki T, Ohtani K, Motomura W, Jang S-J, Mori K, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N.
    • Journal Title

      J Biochem

      Volume: 151(1) Issue: 1 Pages: 57-64

    • DOI

      10.1093/jb/mvr114

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene regulation function of the three specificity protein-1 (Sp1) within the human collectin placenta-1 proximal promoter2011

    • Author(s)
      Kim Y-U, Ohtani K, Mori K, Jang S-J, Suzuki Y, Wakamiya N.
    • Journal Title

      Gene and Genomics

      Volume: 33 Issue: 3 Pages: 275-283

    • DOI

      10.1007/s13258-011-0001-9

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment2011

    • Author(s)
      Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang S-J, Hasebe N, KikuchiK, Itabe H, Yoshida I, Suzuki Y, Wakamiya N.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1810 Issue: 9 Pages: 836-842

    • DOI

      10.1016/j.bbagen.2011.06.013

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P12011

    • Author(s)
      Fukuda M, Ohtani K, Jang S-J, Yoshizaki T, Mori K, Motomura W, Yoshida I, Suzuki Y, Kohgo Y, Wakamiya N.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1810 Issue: 12 Pages: 1150-1159

    • DOI

      10.1016/j.bbagen.2011.09.016

    • NAID

      120005828837

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Collectin CL-P1 is an endocytosis and phagocytosis receptor using scavenger receptor CL-P1 is an endocytosis receptor using clathrin-dependent endocytosis pathway and clathrin-independent phagocytosis pathway2013

    • Author(s)
      Wakamiya N
    • Organizer
      European Meeting on Complement in Human Desease
    • Place of Presentation
      Jena (Germany)
    • Year and Date
      2013-08-17
    • Related Report
      2013 Final Research Report
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸
    • Organizer
      日本糖質学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-08-05
    • Related Report
      2013 Final Research Report
  • [Presentation] The biological functions and blood concentration of CL-K12013

    • Author(s)
      Wakamiya N
    • Organizer
      International carbohydrate Symposium
    • Place of Presentation
      Madrid (Spain)
    • Year and Date
      2013-07-09
    • Related Report
      2013 Final Research Report
  • [Presentation] The biological functions of the novel collectins CL-L1, CL-K1, and CL-P12013

    • Author(s)
      Wakamiya N
    • Organizer
      International Society of development and comparative immunology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2013-07-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Collectin and scavenger receptor CL-P1 is an endocytosis receptor using clathrin-dependent endocytosis pathway and clathrin- independentphagocytosis pathway2013

    • Author(s)
      Wakamiya N
    • Organizer
      European Carbohydrate symposium
    • Place of Presentation
      Tel-Aviv (Israel)
    • Year and Date
      2013-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸
    • Organizer
      補体シンポジウム
    • Place of Presentation
      旭川
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] The Biological Functions of the Novel Collectins CL-L1, CL-K1, and CL-P12013

    • Author(s)
      Ohtani K, Mori K, Matsuda Y, Yoshida I, Suzuki Y, Wakamiya N
    • Organizer
      12th Congress of the International Society of Developmental and Comparative Immunology
    • Place of Presentation
      Fukuoka (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The biological functions and blood concentration of CL-K12013

    • Author(s)
      Wakamiya N, Ohtani K, Yoshizaki T, Mori K, Matsuda Y, Yoshida I, Suzuki Y
    • Organizer
      International Carbohydrate Symposium
    • Place of Presentation
      Madrid (Spain)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸、ロイニタイ、森健一郎、黄仁秀、大谷克城、若宮伸隆
    • Organizer
      第32回 日本糖質学会
    • Place of Presentation
      大阪国際交流センター (大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸、ロイニタイ、森健一郎、黄仁秀、大谷克城、若宮伸隆
    • Organizer
      第50回 補体シンポジウム
    • Place of Presentation
      旭川医科大学(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレクチンCL-L1の組織局在と分子構造に関する解析2013

    • Author(s)
      松田泰幸、ロイニタイ、森健一郎、黄仁秀、大谷克城、若宮伸隆
    • Organizer
      第86回 日本生化学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Collectin and scavenger receptor CL-P1 is an endocytosis receptor using clathrin-dependent endocytosis pathway and clathrin-independent phagocytosis pathway2013

    • Author(s)
      Wakamiya N, Jang SJ, Fukuoh A, Mori K, Suzuki Y, Ohtani K
    • Organizer
      17th European Carbohydrate Symposium
    • Place of Presentation
      Tel-Aviv (Israel)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Collectin CL-P1 is an endocytosis and phagocytosis receptor using clathrin-dependent endocytosis pathway and clathrin-independent phagocytosis pathway2013

    • Author(s)
      Wakamiya N, Jang SJ, Fukuoh A, Mori K, Suzuki Y, Ohtani K
    • Organizer
      14th European Meeting on Complement in Human Disease
    • Place of Presentation
      Jena (Germany)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 組織におけるコレクチンCL-K1の生化学的検討2012

    • Author(s)
      大谷克城
    • Organizer
      日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] The biological functions and tissue expressions in Collectin Kidney 1 (CL-K1)2012

    • Author(s)
      Wakamiya N
    • Organizer
      International Complement Workshop
    • Place of Presentation
      Chania, Crete (Greece)
    • Year and Date
      2012-10-10
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] コレクチンCL-K1のマウスおよびヒト組織における発現検討2012

    • Author(s)
      大谷克城
    • Organizer
      日本糖質学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] コレクチンCL-K1の組織における発現検討2012

    • Author(s)
      大谷克城
    • Organizer
      補体シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] コレクチンCL-K1のマウスおよびヒト組織における発現検討2012

    • Author(s)
      大谷克城、本村亘、吉崎隆之、森健一郎、松田泰幸、黄仁秀、ロイ チャンドラ、吉田逸朗、鈴木定彦、若宮伸隆
    • Organizer
      第31回 日本糖質学会
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレクチンCL-K1の組織における発現検討2012

    • Author(s)
      大谷克城、本村亘、吉崎隆之、森健一郎、松田泰幸、黄仁秀、ロイ チャンドラ、吉田逸朗、鈴木定彦、若宮伸隆
    • Organizer
      第49回 補体シンポジウム
    • Place of Presentation
      大阪府立成人病センター(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 組織におけるコレクチンCL-K1の生化学的検討2012

    • Author(s)
      大谷克城、吉崎隆之、森健一郎、本村亘、黄仁秀、吉田逸朗、金然旭、鈴木定彦、若宮伸隆
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] コレクチンCL-P1のリガンド認識ドメインについての解析2011

    • Author(s)
      森健一郎
    • Organizer
      日本糖質学会
    • Place of Presentation
      長岡
    • Year and Date
      2011-07-11
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] CL-P1 mediates oxLDL endocytosis by associating with AP-2 µ22010

    • Author(s)
      SeongJae Jang, Scavenger receptor
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] SCAVENGER RECEPTOR, CL-P1 MEDLATES OXLDL ENDOCYTOSIS BY ASSOCIATING WITH AP-2 μ22010

    • Author(s)
      SeongJae Jang
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/microbio/microbiology.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 旭川医科大学ホームページ

    • URL

      http://www.asahikawa-med.ac.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/microbio/microbiology.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 虚血性疾患亢進作用を有するポリペプ チド2013

    • Inventor(s)
      若宮伸隆、大谷克城、坂本隆志、岸 雄一郎
    • Industrial Property Rights Holder
      扶桑薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-08-29
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 虚血性疾患亢進作用を有するポリペプチド2011

    • Inventor(s)
      若宮 伸隆、芥子 宏行、大谷 克城、坂本 隆志、岸 雄一郎
    • Industrial Property Rights Holder
      扶桑薬品工業株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-03-04
    • Acquisition Date
      2013-08-29
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2010-11-30   Modified: 2019-07-29  

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