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The regulation of tissue morphogenesis by non-coding RNAs

Research Project

Project/Area Number 22590266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIJIMA Yasunobu  東京大学, 大学院・医学系研究科, 助手 (90272426)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsnoncoding RNA / miR-199a / miR-214 / 形態形成 / 骨形成 / 心筋傷害 / non-coding RNA / micro RNA / 組織形成 / Dnm3os
Research Abstract

Our research group previously established the Dnm3os gene knockout mice. This gene encodes noncoding RNAs (ncRNAs) including miR-199a and miR-214. Since the mice displayed small body size with hypoplasia of bones and muscular tissues, the author assumed that these noncoding RNAs might regulate tissue morphogenesis. In order to clarify our hypothesis, the author knocked in miR-199a and/or miR-214 in the Dnm3os locus using the recombinase-mediated cassette exchange (RMCE) method. The authorconfirmed that the recovery of the expression of each miRNA among knocked in animals, but the recovery of abnormal phenotypes was observed only when both miRNAs were knocked in. Thus, it became clear that each noncoding RNA contributed to the tissue formation. The author tried to identify the target genes of these ncRNAs in P19 cells by using a unique dual drug selection system, but there seemed no gene displaying remarkable changes in expression. This could reflect the well-known feature of miR s that … More generally suppress the expression level of many genes with a small extent. As miR-199a and miR-214 were reported to change the expression levels in some heart problems, we suspected these genes could be involved in the pathogenesis of heart dysfunctions. Since our research group previously demonstrated that ETAR-positive cells contributed to the formation of heart and vessel systems, the author knocked in these ncRNAs to the ETAR locus using the RMCE method, and compared the histology of hearts with the control animals. Heart injury was induced by the administration of doxorubicin, which was known to cause severe heart injury in high dose in human. As a result, doxorubicin induced myocardial fibrosis in the control animals, but the fibrosis was considerably suppressed in the heart of miR-knocked in animals. These results suggested that miR-199a/214 might contribute to the maintenance of the normal heart function. Additionally, the results obtained here clearly demonstrated that this knock in system was an effective tool to investigate not only the mechanisms oftissue development but also the involvement of genes in disease. Less

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (36 results) Remarks (3 results)

  • [Journal Article] Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling2013

    • Author(s)
      Arima Y, Miyagawa-Tomita S, Maeda K, Asai R, Seya D, Minoux m、Rijli FM, 西山 K, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H.
    • Journal Title

      Nature Communications

      Volume: 3 Pages: 1267-1277

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preotic neural crest cells contribute to coronary smooth muscle involving endothelin signalling.2012

    • Author(s)
      Yuichiro Arima
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 1267-1267

    • DOI

      10.1038/ncomms2258

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement2011

    • Author(s)
      Arima S, Nishiyama K, Ko T, Arima Y, Hakozaki Y, Sugihara, Koseki H, Uchijima Y, Kurihara Y, Kurihara H.
    • Journal Title

      Development

      Volume: 138 Pages: 4763-4776

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressiong cells in the mouse kidney2011

    • Author(s)
      Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
    • Journal Title

      Gene Expression Patterns

      Volume: 11 Pages: 371-377

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H12011

    • Author(s)
      Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H
    • Journal Title

      Journal of Cell Sciences

      Volume: 124 Pages: 1214-1223

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial movement2011

    • Author(s)
      Satoshi Arima, Koichi Nishiyama
    • Journal Title

      Development

      Volume: 138(21) Pages: 4763-4776

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney2011

    • Author(s)
      Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
    • Journal Title

      Gene Expr. Patterns

      Volume: 11 Issue: 7 Pages: 371-377

    • DOI

      10.1016/j.gep.2011.04.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H12011

    • Author(s)
      Kazuo Tonami
    • Journal Title

      J Cell Sci

      Volume: 124(Pt8) Pages: 1214-1223

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Racl activity and cell motility through interaction with GEF-H12011

    • Author(s)
      Tonami K
    • Journal Title

      J.Cell Sci.

      Volume: 124 Pages: 1214-1223

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest2010

    • Author(s)
      Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 120 Pages: 2817-2828

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field, with a later implication of this signaling pathway in chamber myocardium formation2010

    • Author(s)
      Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H.
    • Journal Title

      Development

      Volume: 137 Pages: 3823-3833

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of mice expressiong EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst2010

    • Author(s)
      Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 18 Pages: 4702-4722

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest2010

    • Author(s)
      Kawamura Y
    • Journal Title

      J.Clin.Invest.

      Volume: 120 Pages: 2817-2828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation2010

    • Author(s)
      Asai R
    • Journal Title

      Development

      Volume: 137 Pages: 3823-3833

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst2010

    • Author(s)
      Fujimoto C
    • Journal Title

      J.Comp.Neurol.

      Volume: 18 Pages: 4702-4722

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating intergenic enhanceractivity of Dlx5 and Dlx6 in mouse embryo2012

    • Author(s)
      Uchijima Y, Kurihara Y, Kushiyama S, Kurihara H.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡(福岡県福岡市)
    • Year and Date
      2012-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice2012

    • Author(s)
      Kawamura Y, Uchijima Y, Nishiyama K, Kurihara Y, Kita K, Kurihara H.
    • Organizer
      Cell Symposia Functional RNAs
    • Place of Presentation
      Hotel Melia (スペイン)
    • Year and Date
      2012-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of non-coding RNA: Evf2 in the Endothelin signaling in branchial arch development2012

    • Author(s)
      Kurihara, Y, Uchijima Y, Kushiyama S, Kurihara H
    • Organizer
      Keystone Symposia Conference Noncoding RNAs
    • Place of Presentation
      スノーバード・クリフロッジ(米国)
    • Year and Date
      2012-04-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development2012

    • Author(s)
      Yukiko Kurihara
    • Organizer
      Keystone Symposia Canference Non-Coding RNAs
    • Place of Presentation
      スノウバード・クリフロッジ(米国)
    • Year and Date
      2012-04-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] novel roles of the neural crest in coronary artery formation through the Endothelin-1/Endothelin A receptor signaling2012

    • Author(s)
      Arima Y, Miyagawa-Tomita S, Nishiyama K, Asai R, Kim KS, Uchijima Y, Ogawa H, Kurihara Y. Kurihara H.
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating integenic enhancer activity of Dlx5 and Dlx6 in mouse embryo2012

    • Author(s)
      Yasunobu Uchijima
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice2012

    • Author(s)
      Yumiko Kawamura
    • Organizer
      Cell Symposia; Functional RNAs
    • Place of Presentation
      Hotel Melia, Sitges, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis2012

    • Author(s)
      Taro Kitazawa
    • Organizer
      Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
    • Place of Presentation
      フォーポイント・バイ・シェラトン・ロサンゼルス(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下顎形成におけるエンドセリンシグナルにおけるnon-codingRNAとパラスペックル蛋白の作用2011

    • Author(s)
      栗原由紀子,内島泰信,櫛山櫻,濱崎真夏,西山功一,栗原裕基
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 下顎形成におけるエンドセリンシグナルにおけるnon-coding RNAとパラスペックル蛋白の作用2011

    • Author(s)
      栗原由紀子
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis2011

    • Author(s)
      Taro Kitazawa
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] エンドセリン1/エンドセリンA型受容体を介したシグナルは適切な冠動脈形成に必要である2011

    • Author(s)
      有馬勇一郎
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice.2011

    • Author(s)
      Arima Y, Miyagawa-Tomita S, Nishiyama K, Asai R, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H.
    • Organizer
      American Heart Associatoin Scientific Session
    • Place of Presentation
      オーラン ドコンベンションセンター(米国)
    • Year and Date
      2011-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirt3による参加ストレス防御機構の初期胚発生における役割2011

    • Author(s)
      河村悠美子,内島泰信,藤澤興,西山功一,栗原由紀子,栗原裕基
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway.2011

    • Author(s)
      Kim KS, Arima Y, Asai R, Sato T, Uchijima Y, Nishiyama K, Kurihara Y, Igarashi T, Kurihara H.
    • Organizer
      211 Pediatric Academic Societies and Asian Society for Pediatric Research Jont Meeting
    • Place of Presentation
      Denver Convention Center(米国)
    • Year and Date
      2011-05-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium2010

    • Author(s)
      Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Saga Y, Miyagawa-Tomita S, Kurihara H.
    • Organizer
      第33回日本分子生物学会・第 83 回日本 生化学会 合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium2010

    • Author(s)
      Rieko Asai
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Abnormal craniofacial morphogenesis induced by ectopic expression of Hoxgenes2010

    • Author(s)
      Taro Kitazawa
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest2010

    • Author(s)
      Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Asano T, Amano T, Kurihara Y, Kurihara H.
    • Organizer
      第33回日本分子生物学会・第 83 回日本生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest2010

    • Author(s)
      Yumiko Kawamura
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelin-1-mediated intracellular trafficking of endothelin receptor type A is regulated by the cytoplasmic C-termin us and causes the subtype-specific signaling in craniofacial development2010

    • Author(s)
      Kou Fujisawa
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcriptional regulation of non-coding RNA Evf-2 in the Endothelin-1/Dlx5/Dlx6 pathway2010

    • Author(s)
      Uchijima Y, Kurihara Y, Sato T, Fujisawa K, Kushiyama S, Kurihara H.
    • Organizer
      第33回 日本分子生物学会・第 83 回 日本 生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] In-depth analysis of angiogenic morphogenesis through time-lapse imaging and quantification2010

    • Author(s)
      西山功一
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会合同年会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of non-coding RNA in the Endotelin signaling in branchial arch development2010

    • Author(s)
      Yukiko Kurihara
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcriptional regulation of non-coding RNA Evf-2 in the Endothelin-1/Dlx5/Dlx6 pathway2010

    • Author(s)
      Yasunobu Uchijima
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会合同年会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel insight into angiogenesis : In-depth analysis through time-lapse imaging and quantification2010

    • Author(s)
      西山功一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel approach toward an understanding of angiogenesis using in vitro time-lapse live imaging2010

    • Author(s)
      西山功一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] A newly identified phenomenon "Cell-mixing" during angiogenesis2010

    • Author(s)
      西山功一
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A type receptor knock out mice2010

    • Author(s)
      Yuichiro Arima
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sirt3, a mitochondrial sirtuin, protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest2010

    • Author(s)
      Yumiko Kawamura
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胚形成を通してみるGPCRの機能解析--エンドセリン受容体のサブタイプ特異性-2010

    • Author(s)
      Kou Fujisawa
    • Organizer
      第7回東京呼吸器リサーチフォーラム
    • Place of Presentation
      帝人本社(東京都千代田区)
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスにおける冠動脈の発生とその異常2010

    • Author(s)
      Yuichiro Arima
    • Organizer
      第9回心臓血管発生研究会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] エンドセリンA受容体の発現による一次心臓領域におけるchamber myocardium寄与細胞系譜の同定2010

    • Author(s)
      浅井理恵子
    • Organizer
      第9回心臓血管発生研究会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium2010

    • Author(s)
      Rieko Asai
    • Organizer
      Weinstein 2010 cardiovascular development conference
    • Place of Presentation
      Royal Tropical Institute (AMSTERDAM, The Netherlands)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-cording RNA regulation of endothelin signaling in branchial arch development2010

    • Author(s)
      Yukiko Kurihara
    • Organizer
      Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
    • Place of Presentation
      Il Ciocco Hotel & Resort (Lucca, Italy)
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Subtype-specific domain functions of endothelin receptors in craniofacial development2010

    • Author(s)
      Kou Fujisawa
    • Organizer
      Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
    • Place of Presentation
      Il Ciocco Hotel & Resort (Lucca, Italy)
    • Year and Date
      2010-04-12
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://bio.m.u-tokyo.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://bio.m.u-tokyo.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://bio.m.u-tokyo.ac.jp/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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