Roles of small GTPases and ROS in functions anddiseases of inner ear
| Project/Area Number |
22590271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
UEYAMA Takehiko 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 准教授 (80346254)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Hirofumi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00515223)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | small GTPases / ROS / inner ear / hearing / balancing / 内耳 / 聴覚 / 平衡覚 / 活性酸素 / 活性酸素種 |
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| Research Abstract |
1. We engineered a genetically modified mice-line producing ROS, and found that the mice-line was vulnerable to noise exposure. The vulnerability to ROS was inhibited by the scavenger of ROS.
2. We engineered a knockout (KO) mice-line manifesting progressive hearing loss. Now we are extensively analyzing the molecular mechanism of deafness in the KO mice.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Direct binding of RalA to ηPKC and its crucial role in morphological change during keratinocyte differentiation2011
Author(s)
Shirai Y, Morioka S, Sakuma M, Yoshino Kl, Otsuji C, Sakai N, Kashiwagi K, Chida K, Shirakawa R, Horiuchi H, Nishigori C, Ueyama T, Saito N
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Journal Title
Mol.Biol.Cell
Volume: 22
Pages: 1340-1352
Related Report
Peer Reviewed
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