Functional analysis of CIBZ, a methyl-CpG binding protein which is essential for the ES cell differentiation
| Project/Area Number |
22590272
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
MATSUDA Eishou 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00335481)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ES 細胞 / 細胞増殖 / 細胞分化 / 細胞周期 / DNA メチル化 / 筋芽細胞分化 / 胚性幹（ES）細胞 / DNAメチル化 / メチル化DNA結合タンパク質 / 転写後修飾 / Nanog / ES細胞 / 細胞死 / 転写制御 |
|---|
| Research Abstract |
G1/S transition is important for embryonic stem cell (ESC) proliferation; however, the transcriptional factor that regulates this remains largely unknown. We present data showing that CIBZ, a transcription factor, regulates ESC proliferation and G1/S transition. Our results indicate that CIBZ-associated ESC proliferation and G1/S transition is dependent on Nanog expression.
|
Report
(4 results)
Research Products
(4 results)
