| Project/Area Number |
22590275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
OKUDA Akihiko 埼玉医科大学, 医学部, 教授 (60201993)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Hidemasa 埼玉医科大学, 医学部, 講師 (50292123)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発生医学 / ES細胞 / 未分化性 / 自己増殖性 / 多分化能 / 転写因子 / Myc / Max / Oct3/4 / c-Myc / 自己増殖 / Myc module活性 / Core module活性 / 細胞移植 |
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| Research Abstract |
Embryonic stem (ES) cells are defined by their two remarkable properties, i.e., pluripotent and indefinite self-renewal properties. Although some papers had suggested the involvement of Myc family proteins including c-Myc protein for sustaining these prominent properties which ES cells have, this issue has never been addressed from the gene targeting analyses. Therefore, we conducted homozygous knockout of Max gene encoding an indispensable partner protein for all three Myc proteins (c-Myc, N-Myc and L-Myc) to exert their transcriptional activities as well as oncogensis promoting activities.
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