Analysis of histone acetylase Hbo1, involved in DNA replication

• Project/Area Number: 22590276
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Teikyo University
• Principal Investigator: IIZUKA Masayoshi 帝京大学, 医学部, 准教授 (20232118)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳がん / アセチル化 / エストロゲン受容体 / ユビキチン化 / Hbo1 / ユビキチン / ヒストン / クロマチン / DNA複製

Research Abstract

Approximately ten thousands Japanese women die of breast cancers. About two -thirds of breast cancers were regulated by sex hormone, estrogen. Anti-estrogen therapy has been developed with considerable success. However, some breast cancers are resistant to that treatment presumably due to functional alteration of the estrogen receptor. I found that a chromatin modifying enzyme, Hbo1, contributes to protein degradation of the estrogen receptor.

Research Products

• [Journal Article] Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation (2011)
  • Author(s): Nozomi Sugimoto
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Issue: 45 Pages: 39200-39210
  • DOI: 10.1074/jbc.m111.256123
  • Peer Reviewed
• [Journal Article] Degradation of p21Cip1 through APC/CCdc20 mediated ubiquitylation is inhibited by cyclin dependent kinase 2 in cardiomyocytes (2011)
  • Author(s): Yamada, K, Tamamori-Adachi, M, Goto I, Iizuka, M, Yasukawa, T, Asao, T, Okazaki, T, Kitajima, S
  • Journal Title: J. Biol. Chem Volume: 286 Issue: 51 Pages: 44057-66
  • DOI: 10.1074/jbc.m111.236711
  • Peer Reviewed
• [Journal Article] Negative regulation of parathyroid hormone-related protein expression by steroid hormones (2011)
  • Author(s): Kajitani, T, Tamamori-Adachi, M, Okinaga, H, Chikamori, M, Iizuka, M, Okazaki, T
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Issue: 3 Pages: 472-8
  • DOI: 10.1016/j.bbrc.2011.03.037
  • Peer Reviewed
• [Presentation] ヒトアセチルトランスフェラーゼ Hbo1 タンパク質複合体によるエストロゲン受容体タンパク質のユビキチン化を介した不安定化 (2012)
  • Author(s): 飯塚眞由
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡国際会議場 (福岡)
  • Year and Date: 2012-12-14
• [Presentation] Regulation of estrogen receptor stability by histone acetyltransferase Hbo1 ヒストンアセチルトランスフェラーゼ Hbo1 によるエストロゲン受容体タンパク質の安定性の制御 (2012)
  • Author(s): 飯塚眞由
  • Place of Presentation: さっぽろ芸文館(札幌)
  • Year and Date: 2012-09-20
• [Presentation] ヒストンアセチルトランスフェラーゼ Hbo1 タンパク質複合体によるエストロゲン受容体タンパク質のユビキチン化を介した不安定化 (2012)
  • Author(s): 飯塚眞由
  • Organizer: 分子生物学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Characterization of Hbo1 histone acetyltransferase (2011)
  • Author(s): Masayoshi Iizuka
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-16
• [Remarks]
  • URL: http://iizukalab.jp
• [Remarks]
  • URL: http://iizukalab.jp