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Regulation of stress activated protein kinase pathway by protein phosphatase 2C

Research Project

Project/Area Number 22590280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionTohoku University

Principal Investigator

TAMURA Shinri  東北大学, 加齢医学研究所, 教授 (20124604)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Takayasu  東北大学, 加齢医学研究所, 准教授 (10221970)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsプロテインホスファターゼ / PP2C / 小胞体 / ストレス応答 / 小胞体ストレス / PP2Cε / INK / IRE1α
Research Abstract

In this study we identified acyl CoA binding domain containing 3 (ACBD3) as a binding partner of PPM1L and suggested that ACBD3 recruits PPM1L to the ER-Golgi membrane contact site. We also demonstrated that PPM1L interacts with GOLD(Golgi dynamics) domain that exists in several proteins involved in Golgi function.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (22 results)

  • [Journal Article] N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells2013

    • Author(s)
      Chida, T.
    • Journal Title

      Biochem J

      Volume: 449 Issue: 3 Pages: 741-749

    • DOI

      10.1042/bj20121201

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2012

    • Author(s)
      Shinoda, Y.
    • Journal Title

      FEBS Letter

      Volume: 586 Issue: 19 Pages: 3024-3029

    • DOI

      10.1016/j.febslet.2012.06.050

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shigeru Tsuiki : a pioneer in the research fields of complex carbohydrates and protein phosphatases2011

    • Author(s)
      T.Miyagi, et. al.
    • Journal Title

      J.Biochem.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts2011

    • Author(s)
      N.Fukuno, et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Golgi complex-associated protein of 60 kDa (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2013

    • Author(s)
      Shinoda,Y
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Targeted disruption of the mouse protein phosphatase 2Cε gene leads to structural abnormalities in the brain2013

    • Author(s)
      Fujita, K
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Golgi complex-associated protein of 60 kDa (GCP60) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2013

    • Author(s)
      Shinoda, Y.
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Targeted disruption of the mouse protein phosphatase 2Cε gene leads to structural abnormalities in the brain2013

    • Author(s)
      Fujita, K.
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Golgi complex-associated protein of 60 kDa (GCP60) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2013

    • Author(s)
      篠田康晴
    • Organizer
      10th International Conference on Protein Phosphatase
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテインホスファターゼPP2Cεによる小胞体ストレス応答の制御2012

    • Author(s)
      永浦裕子
    • Organizer
      日本生化学会東北支部第78回例会
    • Place of Presentation
      山形
    • Year and Date
      2012-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Golgi complex-associated protein of 60 kDa (ACBD3) recruits the protein phosphatase PPM1L toER-Golgi membrane contact sites2012

    • Author(s)
      篠田康晴
    • Organizer
      第35回日本分子生物学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ノックアウトマウスを用いたPP2Cεの新規機能解明2012

    • Author(s)
      藤田宏介
    • Organizer
      第35回日本分子生物学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] プロテインホスファターゼ2Cによる細胞機能の制御2012

    • Author(s)
      田村眞理
    • Organizer
      第5回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] N-ミリストイル化はPP2CαおよびPP2Cβの機能発揮に必須である2012

    • Author(s)
      小林孝安
    • Organizer
      第5回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] ノックアウトマウスを用いたPP2Cεの新規機能解明2012

    • Author(s)
      藤田宏介
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Golgi complex-associated protein of 60 kDa (GCP60) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2012

    • Author(s)
      篠田康晴
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Golgi complex-associated protein of 60 kDa (GCP60) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2012

    • Author(s)
      篠田康晴
    • Organizer
      第35回日本分子生物学会総会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of Cellular Functions by PP2C Family Members2011

    • Author(s)
      田村眞理
    • Organizer
      発がんスパイラル第1回国際シンポジウム&第9回プロテインボスファターゼ国際カンファランス
    • Place of Presentation
      東京
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] AMP Activated Protein Kinase (AMPK) is Regulated by Multiple Protein Phosphatase2011

    • Author(s)
      小林孝安
    • Organizer
      発がんスパイラル第1回国際シンポジウム&第9回プロテインボスファターゼ国際カンファランス
    • Place of Presentation
      東京
    • Year and Date
      2011-02-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] PP2Cδ/ILKAPはcaspase-3の新たな基質である2011

    • Author(s)
      神藤佑亮
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] PP2Cδ/ILKAP stabilizes p53 through regulation of the Akt-GSK3β pathway2011

    • Author(s)
      千田透子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanobiological regulation of bone remodeling cycle by the expression of cytokine-related genes via JNK and p38 inosteoblast2011

    • Author(s)
      松井裕之
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] N-ミリストイル化はPP2Cαおよびβの機能発揮に必須である2011

    • Author(s)
      小林孝安
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] AMPK activated Protein Kinase (AMPK)の脱リン酸化を担うプロテインホスファターゼの解析2010

    • Author(s)
      小林孝安
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨芽細胞のJNKおよびp38はメカノバイオロジーにおいて破骨細胞とのサイトカインクロストークに寄与する2010

    • Author(s)
      松井裕之
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] PP2CζはJNKにより負の制御を受ける2010

    • Author(s)
      小林孝安
    • Organizer
      日本生化学会東北支部第76回例会・シンポジウム
    • Place of Presentation
      福島
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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