Regulation of stress activated protein kinase pathway by protein phosphatase 2C
| Project/Area Number |
22590280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAMURA Shinri 東北大学, 加齢医学研究所, 教授 (20124604)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takayasu 東北大学, 加齢医学研究所, 准教授 (10221970)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | プロテインホスファターゼ / PP2C / 小胞体 / ストレス応答 / 小胞体ストレス / PP2Cε / INK / IRE1α |
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| Research Abstract |
In this study we identified acyl CoA binding domain containing 3 (ACBD3) as a binding partner of PPM1L and suggested that ACBD3 recruits PPM1L to the ER-Golgi membrane contact site. We also demonstrated that PPM1L interacts with GOLD(Golgi dynamics) domain that exists in several proteins involved in Golgi function.
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Report
(4 results)
Research Products
(26 results)
