| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A possible role of coagulation factor XIII (FXIII) in invasion of macrophages was examinedusing catalytic A subunit of FXIII (FXIII-A)-deficient mice. FXIII-A-deficient macrophagesshowed lower chemotactic ability than wildtype cells, although it was not stationerysignificant. In the heart tissue of lipopolysaccharide (LPS)-treated wildtype mice, type Icollagen transiently increased lesions where macrophages invaded. In contrast, depositionof type I collagen hardly increased in heart of FXIII-A-deficient mice treated with LPS.Thus, it was suggested that FXIII-A inside cells involved in chemotaxis of macrophages,and FXIII-A contributed to increase of type I collagen deposition in damaged tissues.
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