Role of coagulation factor XIII in invasion of macrophages
| Project/Area Number |
22590281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | XIII因子 / 架橋結合 / 炎症と血液凝固 / 単球 / マクロファージ |
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| Research Abstract |
A possible role of coagulation factor XIII (FXIII) in invasion of macrophages was examinedusing catalytic A subunit of FXIII (FXIII-A)-deficient mice. FXIII-A-deficient macrophagesshowed lower chemotactic ability than wildtype cells, although it was not stationerysignificant. In the heart tissue of lipopolysaccharide (LPS)-treated wildtype mice, type Icollagen transiently increased lesions where macrophages invaded. In contrast, depositionof type I collagen hardly increased in heart of FXIII-A-deficient mice treated with LPS.Thus, it was suggested that FXIII-A inside cells involved in chemotaxis of macrophages,and FXIII-A contributed to increase of type I collagen deposition in damaged tissues.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Severe inhibitor-negative acquired factorXIII/13 deficiency with aggressivesubdural haemorrhage2013
Author(s)
Kawano H, Yamamoto D, Uchihashi Y, Wakahashi K, Kawano Y, Sada A, Minagawa K, Katayama Y, Kohmura E,Souri M, Ichinose A.
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Journal Title
Blood Coagul Fibrinolysis
Volume: (印刷中)
Issue: 6
Pages: 638-41
DOI
Related Report
Peer Reviewed
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