Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Research Abstract |
Progression of cancer is induced by cancer associated fibroblasts (CAF). Recent reports have indicated that CAF is derived from tumor endothelial cells through endothelial-to-mesenchymal transition (EndMT). In the present study, we studied the molecular mechanisms underlying EndMT. Using MS-1 endothelial cells, I have found that activation of MRTF-A transcription factor by Rho signals is necessary for TGF-β-induced EndMT. I also found that BMP-9 and FGF enhanced and suppressed the TGF-β-induced EndMT. These results suggest that signaling cascades mediated by multiple cytokines modulate the TGF-β-induced EndMT.
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