| Project/Area Number |
22590285
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
SADA Kiyonao 福井大学, 医学部, 教授 (10273765)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CHIHARA Kazuyasu 福井大学, 医学部, 准教授 (00314948)
TAKEUCHI Kenji 福井大学, 医学部, 助教 (40236419)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HOTTA Hak 神戸大学, 大学院・医学研究科, 教授 (40116249)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 分子病態学 / C型肝炎ウイルス / シグナル伝達 / チロシンキナーゼ / 糖尿病 / プロテオーム解析 |
|---|
| Research Abstract |
We have focused on tyrosine phosphorylation of viral proteins as the pathogenesis of Hepatitis C virus (HCV) in B cells, and identified that HCV-NS5A protein associates with and activates protein-tyrosine kinase Fyn which regulates the tumor and immune signal transduction in B cells. This suggests that HCV infection may affect the dysfunction of B cells and immunological surveillance. In addition, we found the blood glucose concentration and AMP-activated protein kinase (AMPK) regulates HCV replication through the proteome analysis.
|
