| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The anti-inflammatory protein annexin-1 is a potent mediator of inflammation resolution and a 37-kDa member of the annexin family of calcium and phospholipid-binding proteins, expressed constitutively in many cells, including neutrophil. The purpose of this study was to investigate the effect of annexin-1 protein as an endogenous regulator of anti-inflammatory effect and extracellular traps. Annexin1 directly bound to p65 of NF-kB. Annexin 1 also released to extracellular space with nuclear DNA during formation of extracellular traps.
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