Analysis of new function of anti-inflammatory protein
| Project/Area Number |
22590288
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Suzuka University of Medical Science (2011-2012)
Osaka City University (2010) |
|---|
Principal Investigator |
SATO Eisuke 鈴鹿医療科学大学, 薬学部, 教授 (60211942)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | アネキシン1 / 活性酸素 / アポトーシス / ネットーシス / 抗炎症タンパク質 / 好中球 / 炎症 / 細胞外トラップ / アネキシン１ / extracellular trap / 抗炎症蛋白 / アネキシン / エンドトキシン / NF-kB / トランスジェニックマウス |
|---|
| Research Abstract |
The anti-inflammatory protein annexin-1 is a potent mediator of inflammation resolution and a 37-kDa member of the annexin family of calcium and phospholipid-binding proteins, expressed constitutively in many cells, including neutrophil. The purpose of this study was to investigate the effect of annexin-1 protein as an endogenous regulator of anti-inflammatory effect and extracellular traps. Annexin1 directly bound to p65 of NF-kB. Annexin 1 also released to extracellular space with nuclear DNA during formation of extracellular traps.
|
Report
(4 results)
Research Products
(42 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] A major protein of mycobacteria possesses ferritin2011
Author(s)
M Takatsuka, M Osada-Oka, E Satoh, KKitadokoro, Y Nishiuchi , M Yoshimura , M Inoue , K Iwai , T Arakawa , Y Shimoji, H Ogura , K Kobayashi , A Rambukkana , S Matsumoto
-
Journal Title
superfamily protein-like activity and protects against DNA damage by Fenton reaction PLoS One
Volume: 6(6)
Related Report
-
-
-
-
[Journal Article] Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton2011
Author(s)
Hara, K., Kasahara, E., Takahashi,N., Konishi, M., Jikumaru, M., Inoue, J, Kubo, S., Okamura H., Sato, EF., Inoue, M.
-
Journal Title
Journal of Pharmacology and Experimental Therapeutics
Volume: 337(3)
Pages: 838-845
Related Report
-
-
-
-
[Journal Article] Mitochondria determine the efficacy of anti-cancer agents that interact with DNA but not the cytoskeleton2011
Author(s)
Hara, K., Kasahara, E., Takahashi, N., Konishi, M., Jikumaru, M., Inoue, J, Kubo, S., Okamura H., Sato, EF., Inoue, M.
-
Journal Title
Journal of Pharmacology and Experimental Therapeutics
Volume: 337
Pages: 838-845
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] A major protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction2011
Author(s)
Masaki Takatsuka, Mayuko Osada-Oka, Eisuke Satoh, Kengo Kitadokoro, Yukiko Nishiuchi, Mamiko Yoshimura, Masayasu Inoue, Kazuhiro Iwai, Tetsuo Arakawa, Yoshihiro Shimoji, Hisashi Ogura, Kazuo Kobayashi, Anura Rambukkana, Sohkichi Matsumoto
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
