Study for metabolic regulatory mechanism by a mitochondrial protein and a sex hormone
Project/Area Number |
22590290
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Jichi Medical University |
Principal Investigator |
ENDO Hitoshi 自治医科大学, 医学部, 教授 (50221817)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ミトコンドリア / プロヒビチン / 性ホルモン / 核-ミトコンドリア連関 / 脂肪分化 / プロテオーム / 核―ミトコンドリア連関 / 質量分析 |
Research Abstract |
Prohibitin 2 (PHB2) has been reported as a multifunctional protein that mainly localizes in mitochondria and translocates into nucleus in the presence of estrogen receptor and estrogen. Decrease of estrogen level is a major cause of obesity in early post-
|
Report
(4 results)
Research Products
(31 results)
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[Journal Article] Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites2013
Author(s)
Akimoto, C. Sakashita, E., Kasashima, K., Kuroiwa, K., Tominaga, K., Hamamoto, T., and Endo, H.
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Journal Title
Biochem Biophys Acta
Volume: 1830
Issue: 3
Pages: 2728-2738
DOI
Related Report
Peer Reviewed
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[Journal Article] Epitope determination of anti Thy-1 monoclonal antibodies that regulate neurite outgrowth2012
Author(s)
Kuroiwa, K., Torkai,Y., Osawa, M., Nakashima, T., Nakashima, M., Endo, H., and Arai, T
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Journal Title
Hybridoma
Volume: 31
Issue: 4
Pages: 225-232
DOI
Related Report
Peer Reviewed
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