Pathophysiological analysis of acute muscle atrophy by failure of cysteine biosynthesis and development of its control strategy
| Project/Area Number |
22590292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
ISHII Isao 慶應義塾大学, 薬学部, 准教授 (90292953)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | システイン / 筋萎縮症 / ホモシステイン / アミノ酸代謝 / 硫化水素 / オートファジー / ミオパシー / イメージング / 筋原性筋萎縮 / 神経原性筋萎縮 / 分枝鎖アミノ酸 / グルタチオン / タウリン / 筋萎縮 / ミオパチー / アミノ酸飢餓 / 遺伝子改変 / シスタチオニン尿症 / リスクファクター / 心血管病 |
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| Research Abstract |
We have developed mice lacking cystathionine gamma-lyase (CTH), the final step enzyme for cysteine biosynthesis, and observed acute muscle atrophy when f ed a cyst(e)ine-deficient diet. Our pathological, immunohistochemical, and biochemical analyses revea
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria.2012
Author(s)
Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I
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Journal Title
Free Radic Biol Med
Volume: 52
Issue: 9
Pages: 1716-1726
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway2012
Author(s)
Morikawa T., Kajimura M., Nakamura T., Hishiki T., Nakanishi T., Yukutake Y., Nagahata Y., Ishikawa M., Hattori K., Takenouchi T., Takahashi T., Ishii I., Matsubara K., Kabe Y., Uchiyama S., Nagata E., Gadalla M.M., Snyder S.H., Suematsu M.
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Journal Title
Proc Natl Acad Sci USA
Volume: 109
Issue: 4
Pages: 1293-1298
DOI
Related Report
Peer Reviewed
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[Journal Article] Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria.2011
Author(s)
Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I
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Journal Title
Anal Bioanal Chem
Volume: 400
Issue: 7
Pages: 1853-1863
DOI
Related Report
Peer Reviewed
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[Journal Article] Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthease-deficient mice, an animal model for homocysteinemia/homocytinuria.2011
Author(s)
Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata Y, Matsuura T, Suematsu M, Taguchi R, Ishii I
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Journal Title
Anal.Bioanal.Chem.
Volume: (印刷中)
Related Report
Peer Reviewed
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