| Project/Area Number |
22590294
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Kenichi 日本大学, 医学部, 講師 (20366602)
UMEDA Kaori 日本大学, 医学部, 助手 (10445744)
|
|---|
| Research Collaborator |
SEKI Shuji 防衛医科大学校, 医学教育部医学科専門課, 教授 (80531392)
ISHIZAWA Michiyasu 日本大学, 医学部, 助手 (30646542)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ビタミンD受容体 / 胆汁鬱滞 / 炎症 / インターロイキン6 / マクロファージ / NKT細胞 / NK細胞 / ノックアウトマウス / クッパ－細胞 / リトコール酸 / ビリルビン |
|---|
| Research Abstract |
Vitamin D receptor (VDR) responds to the active form of vitamin D3 and the bile acid lithocholic acid. We investigated the role of VDR in hepatic immune cells. VDR played a limited role in regulation of hepatic genes involved in metabolism and immunity in mice with cholestasis. Inflammatory responses were suppressed in the intestine of VDR-null mice. Increased NK cells and iNKT cells were observed in mononuclear cells from the liver of VDR-null mice. The results show a role of VDR in the intestine-liver pathway.
|
