Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas

Research Project

Project/Area Number	22590295
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pathological medical chemistry
Research Institution	Nihon University
Principal Investigator	CHOI Mihwa 日本大学, 医学部, 助教 (30571012)
Co-Investigator(Kenkyū-buntansha)	ISHIHARA Hisamitsu 日本大学, 医学部, 教授 (60361086)
Co-Investigator(Renkei-kenkyūsha)	MAKISHIMA Makoto 日本大学, 医学部, 教授 (70346146)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	分子病態学 / 膵臓学 / ビタミンD / 標的遺伝子 / 核内受容体 / ビタミンD受容体 / 膵臓 / 転写因子 / 組織特異的 / ペプチドホルモン / VDR / PYY
Research Abstract	We found that Pyy is a VDR target gene in the mouse pancreas. VDR activation increased mRNA and protein expression of PYY in the pancreatic islets of mice and pancreatic endocrine cell lines, but did not change intestinal PYY expression.

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(4 results)