| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The glycosylation is one of the major post-translational modification, which regulates the function of various proteins. There are two types of glycosylation, N-linked and O-linked. Here, I studied about the effect of O-GlcNAcylation, one of the O-linked glycosylation, on the function of cardiac calcium-regulating proteins and ion channels. Although we examined such various proteins in rat adult cardiomyocytes, it was found that O-GlcNAcylation of phospholamban, which plays a crucial role in the regulation of cardiac function, was increased, and, simultaneously, its phosphorylation was inhibited, resulting in the reduction of cardiac function.
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