Functional analyses on the glycosylation in cardiac calcium-regulating proteins and ion channels
| Project/Area Number |
22590297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
ASAHI Michio 大阪医科大学, 医学部, 教授 (10397614)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分子病態学 / 糖鎖 / 循環器・高血圧 / 糖尿病 |
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| Research Abstract |
The glycosylation is one of the major post-translational modification, which regulates the function of various proteins. There are two types of glycosylation, N-linked and O-linked. Here, I studied about the effect of O-GlcNAcylation, one of the O-linked glycosylation, on the function of cardiac calcium-regulating proteins and ion channels. Although we examined such various proteins in rat adult cardiomyocytes, it was found that O-GlcNAcylation of phospholamban, which plays a crucial role in the regulation of cardiac function, was increased, and, simultaneously, its phosphorylation was inhibited, resulting in the reduction of cardiac function.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Asahi M, Hagiwara N, Losordo DW, Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve.2013
Author(s)
Sekiguchi H, Ii M, Jujo K, Thorne T, Ito A, Klyachko E, Hamada H, Kessler JA,Tabata Y, Kawana M
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Journal Title
Angiogenesis.
Volume: 16(1)
Pages: 45-58
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Peer Reviewed
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[Journal Article] CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.2013
Author(s)
Jujo K, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault MA, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, Losordo DW
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Journal Title
Circulation
Volume: 127(1)
Pages: 63-73
Related Report
Peer Reviewed
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[Journal Article] N-glycans of SREC-I (scavenger receptor expressed by endothelial cells): essential role for ligand binding, trafficking and stability2012
Author(s)
Sano M, , Korekane H, Ohtsubo K, Yamaguchi Y, Kato M, Shibukawa Y, Tajiri M, Adachi H, Wada Y, Asahi M, and Taniguchi N
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Journal Title
Glycobiology
Volume: 22(5)
Pages: 714-24
Related Report
Peer Reviewed
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[Journal Article] N-Glycans of SREC-I(scavenger receptorexpressed by endothelial cells): Essential role for ligand binding, traffickingand stability2012
Author(s)
Sano, M., Korekane, H., Ohtsubo, K., Yamaguchi, Y., Kato, M., Shibukawa, Y., Tajiri, M., Adachi, H., Wada, Y., Asahi, M. and Taniguchi, N
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Journal Title
Glycobiology
Volume: 22
Issue: 5
Pages: 714-724
DOI
Related Report
Peer Reviewed
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