Regulation of cancer stem cells by MDMX/MDM2 oncoproteins
| Project/Area Number |
22590299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
OKAMOTO Koji 独立行政法人国立がん研究センター, 研究所, 分野長 (80342913)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | がん幹細胞 / 癌 / かん幹細胞 / p53 |
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| Research Abstract |
We have established in vitro system for cultivation of colon cancer stem cells. Using this system, we have performed biological and biochemical analyses of the p53 pathway and the associated oncoproteins, Mdm2 and Mdmx. We have found that p21, a target gene of p53, is induced upon the differentiation of the cancer stem cells. Further we discovered the activation of the Akt pathway, the HGF-c-Met pathway and glycolytic enzymes. These data suggest that dynamic regulation of the oncogenic pathways are involved in regulation of colon cancer stem cells.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance ofcolon cancer-initiating cells2012
Author(s)
H. Ohata, T. Ishiguro, Y. Aihara, A. Sato, H. Sakai, S. Sekine, H. Taniguchi, T. Akasu, S. Fujita, H. Nakagama, K. Okamoto
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Journal Title
Cancer Res
Volume: 72
Pages: 5101-5110
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[Journal Article] Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p212011
Author(s)
N. Tsuchiya, M. Izumiya, H. Ogata-Kawata, K. Okamoto, Y. Fu j iwara, M. Nakai, A. Okabe, A. J. Schetter, E. D. Bowman, Y. Midorikawa, Y. Sugiyama, H. Aburatani, C. C. Harris, H. Nakagama
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Journal Title
Cancer Res
Volume: 71
Pages: 4628-4639
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