Methods of genome-wide gene-gene interaction analysis
Project/Area Number |
22590300
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
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Research Institution | Yamagata University |
Principal Investigator |
TAMIYA Gen 山形大学, 医学部, 教授 (10317745)
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Co-Investigator(Kenkyū-buntansha) |
UEKI Masao 山形大学, 医学部, 助教 (10515860)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | SNP-GWAS / SNPs / ゲノムワイド関連解析 / モデル選択 / 変数選択 / 遺伝子×遺伝子相互作用 / 高次元変数選択 / 量的形質 |
Research Abstract |
We propose utilizing a model selection strategy for an exhaustive interaction analysis in whole GWA data. Our new software, EPISIS, implements the ‘sure independence screening', which has two major parts, screening and variable selection;EPISIS can complete an exhaustive search for all possible SNP by SNP interactions innon-filtered GWA data within several days under common computing environments. Ourfast program is applied to find novel genetic components in GWA data from WTCCC (Wellcome Trust Case-Control Consortium).
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol Peer-Reviewed papers
Volume: 129(5)
Issue: 5
Pages: 1413-1416
DOI
Related Report
Peer Reviewed
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[Journal Article] Epistatic interaction between TLR3 and PTGER3 genes2012
Author(s)
Ueta U, Tamiya G, Tokunaga T, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study2011
Author(s)
Mashima Y, Konta T, Kudo K, Suzuki K, Ikeda A, Ichikawa K, Shibata Y, Watanabe T, Tamiya G, Kato T, Kawata S, Kubota I.
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Journal Title
Nephrol Dial Transplant
Volume: 26(12)
Issue: 12
Pages: 3902-3907
DOI
Related Report
Peer Reviewed
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[Journal Article] Impair Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population : the Takahata study2011
Author(s)
Mashima Y, Konta T, Kudo K, Suzuki K, Ikeda A, Ichikawa K, Shibata Y, Watanabe T, Tamiya G, Kato T, Kawata S, Kubota I
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Journal Title
Internal Med
Volume: 26(12)
Pages: 3902-3907
Related Report
Peer Reviewed
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