• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis for psoriasis susceptibility gene

Research Project

Project/Area Number 22590304
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionTokai University

Principal Investigator

OKA Akira  東海大学, 総合医学研究所, 講師 (80384866)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords尋常性乾癬 / 感受性遺伝子 / マイクロサテライト / ハプロタイプ / 関連 / 乾癬 / GPCR / EHH / ケモカイン
Research Abstract

The aim of this study was to unravel the function of psoriasis-susceptibility gene we found in the previous our study. In this study, we could discover that the genetic risk factor of the gene in Japanese psoriasis was shared with Korean psoriasis. Moreover, the protein produced by the gene could interacted with another protein which was involved in wound healing and skin inflammation characterized as psoriasis-pathogenesis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (4 results)

  • [Journal Article] Improved loop-mediated isothermal amplification for HLA-DRB1 genotyping using RecA and a restriction enzyme for enhanced amplification specificity.2013

    • Author(s)
      Mitsunaga S
    • Journal Title

      Immunogenetics

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study2012

    • Author(s)
      Harkensee C, Oka A
    • Journal Title

      Japan Marrow Donor Program. Blood

      Volume: 119 Issue: 26 Pages: 6365-72

    • DOI

      10.1182/blood-2012-01-406785

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variants in the COL4A4 gene confer susceptibility to lattice degeneration of the retina2012

    • Author(s)
      Meguro A, Ota M, Kawagoe T, Mizuki N
    • Journal Title

      PLoS One

      Volume: 7 Issue: 6 Pages: e39300-e39300

    • DOI

      10.1371/journal.pone.0039300

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012

    • Author(s)
      Shiina T, Suzuki S, Ozaki Y, Taira H, Kikkawa E, Shigenari A, Oka A, Umemura T, Joshita S, Takahashi O, Hayashi Y, Paumen M, Katsuyama Y, Mitsunaga S, Ota M, Kulski JK, Inoko H
    • Journal Title

      Tissue Antigens.

      Volume: 80 Issue: 4 Pages: 305-16

    • DOI

      10.1111/j.1399-0039.2012.01941.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of an association human dioxin detoxification gene polymorphisms with endometriosis in Japanese women: results of a pilot study.2012

    • Author(s)
      Matsuzaka Y
    • Journal Title

      Environ Health Prev Med.

      Volume: 17 Issue: 6 Pages: 512-7

    • DOI

      10.1007/s12199-012-0281-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population.2012

    • Author(s)
      Shibata H
    • Journal Title

      Psychiatric Genetics

      Volume: 23 Pages: 117-123

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese.2012

    • Author(s)
      Matsuzaka Y
    • Journal Title

      Environmental Toxicology

      Volume: 18 Issue: 10 Pages: 111-222

    • DOI

      10.1002/tox.21839

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current understanding of human genetics and genetic analysis of psoriasis2012

    • Author(s)
      Matsuzaka Y, Oka A, et al
    • Journal Title

      Environ Health Prev Med

      Volume: 39(Epub ahead of print)

    • NAID

      10031184877

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current understanding of human genetics and genetic analysis of psoriasis2011

    • Author(s)
      Oka Akira; Mabuchi Tomotaka; Ozawa Akira, et al
    • Journal Title

      JOURNAL OF DERMATOLOGY

      Volume: 39:3 Issue: 3 Pages: 231-241

    • DOI

      10.1111/j.1346-8138.2012.01504.x

    • NAID

      10031184877

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel splicing variant of CADM2 as a protective transcript of psoriasis2011

    • Author(s)
      Hiruma Azusa; Ikeda Shigaku; Terui Tadashi, et al
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

      Volume: 412:4 Issue: 4 Pages: 626-632

    • DOI

      10.1016/j.bbrc.2011.08.013

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02 : the same deletion observed in other A*24 alleles and A*23:01 allele2011

    • Author(s)
      Mitsunaga Shigeki; Okudaira Yuko; Kunii Nanae, et al
    • Journal Title

      IMMUNOGENETICS

      Volume: 63:8 Issue: 8 Pages: 467-474

    • DOI

      10.1007/s00251-011-0521-0

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw62011

    • Author(s)
      Riveira-Munoz Eva; He Su-Min; Escaramis Georgia, et al
    • Journal Title

      JOURNAL OF INVESTIGATIVE DERMATOLOGY

      Volume: 131:5 Issue: 5 Pages: 1105-1109

    • DOI

      10.1038/jid.2010.350

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Systems Genetics Approach Provides a Bridge from Discovered Genetic Variants to Biological Pathways in Rheumatoid Arthritis2011

    • Author(s)
      Nakaoka Hirofumi; Cui Tailin; Tajima Atsushi, et al
    • Journal Title

      PLOS ONE

      Volume: 6:9 Issue: 9 Pages: e25389-e25389

    • DOI

      10.1371/journal.pone.0025389

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients2010

    • Author(s)
      Michikawa Y, Oka A, Imai T.
    • Journal Title

      BMC Med Genet

      Volume: 11 Pages: 123-123

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes.2010

    • Author(s)
      Kohno T, Oka A, Yokota J
    • Journal Title

      Carcinogenesis

      Volume: 31 Issue: 1 Pages: 834-41

    • DOI

      10.1186/1471-2350-11-123

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetics of Behcet's disease inside and outside the MHC2010

    • Author(s)
      Meguro A, Oka A), Mizuki N
    • Journal Title

      Ann Rheum Dis.

      Volume: 69 Issue: 4 Pages: 747-54

    • DOI

      10.1136/ard.2009.108571

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes.2010

    • Author(s)
      Kohno T, Oka A, Inoko H, Yokota J., et al.
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 834-841

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients.2010

    • Author(s)
      Michikawa Y, Oka A, Inoko H, Imai T., et al.
    • Journal Title

      BMC Med Genet.

      Volume: 11 Pages: 123-133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6.2010

    • Author(s)
      Riveira-Munoz E, He SM, Escaramis G, Oka A, Mabuchi T, Ozawa A, Inoko H, Estivill X., et al.
    • Journal Title

      J Invest Dermatol

      Volume: (Advance online publication)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人および韓国人集団における尋常性乾癬の遺伝学的関連解析2012

    • Author(s)
      岡晃
    • Organizer
      第27回日本乾癬学会
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人および韓国人集団における尋常性乾癬の遺伝学的関連解析2012

    • Author(s)
      岡  晃
    • Organizer
      日本乾癬学会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome-wide association study using microsatellites identifies a new psoriasis susceptibility locus on chromosome 62010

    • Author(s)
      Oka A
    • Organizer
      14th Human Genome Meeting 2010
    • Place of Presentation
      フランス・モンペリエ
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genome-wide association study using microsatellites identifies a new psoriasis susceptibility locus on chromosome 62010

    • Author(s)
      Akira Oka
    • Organizer
      14th Human Genome Meeting 20102
    • Place of Presentation
      モンペリエ・フランス
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi