Functional analysis for psoriasis susceptibility gene
| Project/Area Number |
22590304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Tokai University |
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Principal Investigator |
OKA Akira 東海大学, 総合医学研究所, 講師 (80384866)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 尋常性乾癬 / 感受性遺伝子 / マイクロサテライト / ハプロタイプ / 関連 / 乾癬 / GPCR / EHH / ケモカイン |
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| Research Abstract |
The aim of this study was to unravel the function of psoriasis-susceptibility gene we found in the previous our study. In this study, we could discover that the genetic risk factor of the gene in Japanese psoriasis was shared with Korean psoriasis. Moreover, the protein produced by the gene could interacted with another protein which was involved in wound healing and skin inflammation characterized as psoriasis-pathogenesis.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers.2012
Author(s)
Shiina T, Suzuki S, Ozaki Y, Taira H, Kikkawa E, Shigenari A, Oka A, Umemura T, Joshita S, Takahashi O, Hayashi Y, Paumen M, Katsuyama Y, Mitsunaga S, Ota M, Kulski JK, Inoko H
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Journal Title
Tissue Antigens.
Volume: 80
Issue: 4
Pages: 305-16
DOI
Related Report
Peer Reviewed
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