Analysis of sex hormone actions in noninvasive breast carcinoma

• Project/Area Number: 22590305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tohoku University
• Principal Investigator: SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
• Co-Investigator(Renkei-kenkyūsha): ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 乳癌 / エストロゲン / アロマターゼ / 非浸潤性乳癌 / 応答遺伝子 / マイクロアレイ

Research Abstract

We aimed to characterize the estrogen functions in noninvasive breast carcinomas (DCIS), precursor lesion of the invasive carcinomas (IDC).Results of our present study have demonstrated that (1) estrogen functions in DCIS were different from those in IDC, andC-MYB, RbAp46 and survivin played important roles in DCIS, and (2) intratumoral estrogen concentration in DCIS was markedly decreased following aromatase inhibitor letrozole treatment, and the expression of a great majority of estrogen-induced genes andproliferative activity were markedly decreased following the treatment.These results suggest that estrogen is mainly produced by aromatase in DCIS, and aromatase inhibitors may potently inhibit estrogen actions in these patients.

Research Products

• [Journal Article] Oestrogen-induced genes in ductal carcinoma in situ: their comparison with invasive ductal carcinoma (2012)
  • Author(s): Ebata A, Suzuki T, Takagi K, Miki Y, Onodera Y, Nakamura Y, Fujishima F, Ishida K, Watanabe M, Tamaki K, Ishida T, Ohuchi N, Sasano H
  • Journal Title: Endocr Relat Cancer Volume: 19 (4) Issue: 4 Pages: 485-96
  • DOI: 10.1530/erc-11-0345
  • Peer Reviewed
• [Journal Article] Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1 (2012)
  • Author(s): Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira J, Ishida T, Abe K, Hirakawa H, Chow LW, Suzuki T, Ouchi N, Sasano H
  • Journal Title: J Pathol Volume: 227 (3) Issue: 3 Pages: 357-66
  • DOI: 10.1002/path.4019
  • Peer Reviewed
• [Journal Article] Nucleobindin 2 in human breast carcinoma as a potent prognostic factor (2012)
  • Author(s): Suzuki S, Takagi K, Miki Y, Onodera Y, Akahira J, Ebata A, Ishida T, Watanabe M, Sasano H, Suzuki T.
  • Journal Title: Cancer Sci Volume: 103 (1) Issue: 1 Pages: 136-43
  • DOI: 10.1111/j.1349-7006.2011.02119.x
  • Peer Reviewed
• [Journal Article] Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation (2011)
  • Author(s): Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, Akahira J, Ishida T, Watanabe M, Hirakawa H, Ohuchi N, Sasano H.
  • Journal Title: Int J Cancer Volume: 128 (8) Issue: 8 Pages: 1770-82
  • DOI: 10.1002/ijc.25505
  • Peer Reviewed
• [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer (2011)
  • Author(s): Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M.
  • Journal Title: J Biol Chem Volume: 286 (1) Issue: 1 Pages: 818-29
  • DOI: 10.1074/jbc.m110.156877
  • Peer Reviewed
• [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer (2011)
  • Author(s): Oyama M, Nagashima T, Suzuki T, 以下10名略
  • Journal Title: J Biol Chem Volume: 286 Pages: 818-829
  • Peer Reviewed
• [Journal Article] Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma (2010)
  • Author(s): Sasaki Y, Miki Y, Hirakawa H, Onodera Y, Takagi K, Akahira J, Honma S, Ishida T, Watanabe M, Sasano H, Suzuki T.
  • Journal Title: Cancer Sci Volume: 101 (10) Issue: 10 Pages: 2286-92
  • DOI: 10.1111/j.1349-7006.2010.01673.x
  • NAID: 10027832946
  • Peer Reviewed
• [Journal Article] Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease : comparison with normal breast and breast carcinoma. (2010)
  • Author(s): Sasaki Y, Mildi Y, Hirakawa H, 以下7名略, Suzuki T.
  • Journal Title: Cancer Sci Volume: 101 Pages: 2286-2292
  • NAID: 10027832946
  • Peer Reviewed
• [Presentation] Expression of the zinc finger protein (PLZF) in human breast carcinoma (2012)
  • Author(s): Takagi K, Miki Y, Onodera Y, 以下3名略, Suzuki T.
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
• [Presentation] 乳癌におけるpromyelocytic zinc finger protein (PLZF) の発現 (2012)
  • Author(s): 高木 清司, 三木 康宏, 小野寺 好明, 以下4名略
  • Organizer: 第71回 日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] KLF5 in human breastcancer (2011)
  • Author(s): Takagi K, Miki Y, Onodera Y, 以下4名略, Suzuki T
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] KLF5 in human breast cancer (2011)
  • Author(s): Takagi K, Miki Y, Onodera Y, 以下4名略, Suzuki T
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] Expression of estrogen-related enzymes in benign breast disease comparison with normal breast and breast carcinoma (2010)
  • Author(s): Sasaki Y, Onodera Y, Miki Y, 以下2名略,Suzuki T.
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
• [Presentation] Expression of estrogen-related enzymes in benign breast disease comparison with normal breast and breast carcinoma (2010)
  • Author(s): Sasaki Y, Onodera Y, Miki Y, 以下2名略, Suzuki T.
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪