Analysis of sex hormone actions in noninvasive breast carcinoma
Project/Area Number |
22590305
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Tohoku University |
Principal Investigator |
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
|
Co-Investigator(Renkei-kenkyūsha) |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 乳癌 / エストロゲン / アロマターゼ / 非浸潤性乳癌 / 応答遺伝子 / マイクロアレイ |
Research Abstract |
We aimed to characterize the estrogen functions in noninvasive breast carcinomas (DCIS), precursor lesion of the invasive carcinomas (IDC).Results of our present study have demonstrated that (1) estrogen functions in DCIS were different from those in IDC, andC-MYB, RbAp46 and survivin played important roles in DCIS, and (2) intratumoral estrogen concentration in DCIS was markedly decreased following aromatase inhibitor letrozole treatment, and the expression of a great majority of estrogen-induced genes andproliferative activity were markedly decreased following the treatment.These results suggest that estrogen is mainly produced by aromatase in DCIS, and aromatase inhibitors may potently inhibit estrogen actions in these patients.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Oestrogen-induced genes in ductal carcinoma in situ: their comparison with invasive ductal carcinoma2012
Author(s)
Ebata A, Suzuki T, Takagi K, Miki Y, Onodera Y, Nakamura Y, Fujishima F, Ishida K, Watanabe M, Tamaki K, Ishida T, Ohuchi N, Sasano H
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Journal Title
Endocr Relat Cancer
Volume: 19 (4)
Issue: 4
Pages: 485-96
DOI
Related Report
Peer Reviewed
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[Journal Article] Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A12012
Author(s)
Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira J, Ishida T, Abe K, Hirakawa H, Chow LW, Suzuki T, Ouchi N, Sasano H
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Journal Title
J Pathol
Volume: 227 (3)
Issue: 3
Pages: 357-66
DOI
Related Report
Peer Reviewed
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[Journal Article] Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation2011
Author(s)
Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, Akahira J, Ishida T, Watanabe M, Hirakawa H, Ohuchi N, Sasano H.
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Journal Title
Int J Cancer
Volume: 128 (8)
Issue: 8
Pages: 1770-82
DOI
Related Report
Peer Reviewed
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[Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer2011
Author(s)
Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M.
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Journal Title
J Biol Chem
Volume: 286 (1)
Issue: 1
Pages: 818-29
DOI
Related Report
Peer Reviewed
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[Journal Article] Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma2010
Author(s)
Sasaki Y, Miki Y, Hirakawa H, Onodera Y, Takagi K, Akahira J, Honma S, Ishida T, Watanabe M, Sasano H, Suzuki T.
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Journal Title
Cancer Sci
Volume: 101 (10)
Issue: 10
Pages: 2286-92
DOI
NAID
Related Report
Peer Reviewed
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