Establishment of the new classification "STAT constitutive activated stomach cancer".
| Project/Area Number |
22590308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HINO Rumi 東京大学, 大学院・医学系研究科, 助教 (60451770)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKAYAMA Masashi 東京大学, 大学院・医学系研究科, 教授 (70281293)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 消化管 / 胃癌 / STAT3 / EBウイルス / メチル化 / SOCS3 |
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| Research Abstract |
Through a study of the EB virus-related gastric cancer, I found the possibility that constitutive activation of STAT3 was important to EB virus-related gastric cancer carcinogenesis and progress. In addition, in STAT3, it has been proved that it was extremely important in a carcinogenic process by many studies. I aim at the establishment of "the STAT3 constitutive activated stomach cancer", which paid its attention to transcription factor STAT3. It becomes a model of clinical and pathological approach. In addition, it may become the subgroup connected directly to the treatment and prevention. The clinicopathological significance is extremely high. I report that I elucidated one characteristic molecular side of the STAT3 constitutive activated stomach cancer, in this study.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] ARID1A expression loss in gastric cancer: pathway-dependent roles with and withoutEpstein-Barr virus infection and microsatellite instability2012
Author(s)
Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K, Kunita A, Ushiku T, Uozaki H, Tateishi Y, Hishima T, Iwasaki Y, Ishikawa S, Fukayama M.
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Journal Title
Virchows Arch
Volume: 461(4)
Pages: 367-77
Related Report
Peer Reviewed
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[Journal Article] SOX9 expression and its methylation status in gastric cancer2012
Author(s)
Sun M, Uozaki H, Hino R, Kunita A, Shinozaki A, Ushiku T, Hibiya T,Takeshita K, Isogai M, Takada K,Fukayama M
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Journal Title
Virchows Archiv
Volume: Vol.460
Issue: 3
Pages: 271-279
DOI
Related Report
Peer Reviewed
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[Journal Article] ARID1Aexpression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability2012
Author(s)
Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K,Kunita A, Ushiku T, Uozaki H,Tateishi Y, Hishima T, Iwasaki Y, Ishikawa S, Fukayama M
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Journal Title
Virchows Archiv
Volume: Vol.461
Issue: 4
Pages: 367-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation Epigenotypes2011
Author(s)
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M.
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Journal Title
Cancer Res
Volume: 71
Pages: 7187-97
Related Report
Peer Reviewed
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[Presentation] EBウイルス関連胃癌におけるmicroRNA-141の発現と,発現制御機構としてのメチル化の関係2011
Author(s)
日比谷孝志,坂谷貴司,篠崎綾,孫敏華,日野るみ,牛久哲男,磯貝まや,石川俊平,宇於崎宏,深山正久
Organizer
第8回EBウイルス研究会
Place of Presentation
大阪
Year and Date
2011-07-08
Related Report
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[Book] Gastric Cancer2010
Author(s)
Fukayama M, Shinozaki A, Hino R.
Publisher
Wolters kluwer/Lippincott Williams & Wiilkins, Advances in Surgical Pathology
Related Report
