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Establishment of the new classification "STAT constitutive activated stomach cancer".

Research Project

Project/Area Number 22590308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

HINO Rumi  東京大学, 大学院・医学系研究科, 助教 (60451770)

Co-Investigator(Renkei-kenkyūsha) FUKAYAMA Masashi  東京大学, 大学院・医学系研究科, 教授 (70281293)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords消化管 / 胃癌 / STAT3 / EBウイルス / メチル化 / SOCS3
Research Abstract

Through a study of the EB virus-related gastric cancer, I found the possibility that constitutive activation of STAT3 was important to EB virus-related gastric cancer carcinogenesis and progress. In addition, in STAT3, it has been proved that it was extremely important in a carcinogenic process by many studies. I aim at the establishment of "the STAT3 constitutive activated stomach cancer", which paid its attention to transcription factor STAT3. It becomes a model of clinical and pathological approach. In addition, it may become the subgroup connected directly to the treatment and prevention. The clinicopathological significance is extremely high. I report that I elucidated one characteristic molecular side of the STAT3 constitutive activated stomach cancer, in this study.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (21 results) Book (1 results)

  • [Journal Article] Platelet-derived growth factor-A and vascular endothelial growth factor-C contribute to the development of pulmonary tumor thrombotic microangiopathy in gastric cancer2013

    • Author(s)
      Abe H, Hino R, Fukayama M.
    • Journal Title

      Virchows Arch

      Volume: 462(5) Pages: 523-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus infection as an epigenetic driver of tumorigenesis2012

    • Author(s)
      Kaneda A, Matsusaka K, Aburatani H, Fukayama M.
    • Journal Title

      Cancer Res

      Volume: 72(14) Pages: 3445-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ARID1A expression loss in gastric cancer: pathway-dependent roles with and withoutEpstein-Barr virus infection and microsatellite instability2012

    • Author(s)
      Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K, Kunita A, Ushiku T, Uozaki H, Tateishi Y, Hishima T, Iwasaki Y, Ishikawa S, Fukayama M.
    • Journal Title

      Virchows Arch

      Volume: 461(4) Pages: 367-77

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SOX9 expression and its methylation status in gastric cancer2012

    • Author(s)
      Sun M, Uozaki H, Hino R, Fukayama M.et.al.
    • Journal Title

      Virchows Arch

      Volume: 460(3) Pages: 271-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SOX9 expression and its methylation status in gastric cancer2012

    • Author(s)
      Sun M, Uozaki H, Hino R, Kunita A, Shinozaki A, Ushiku T, Hibiya T,Takeshita K, Isogai M, Takada K,Fukayama M
    • Journal Title

      Virchows Archiv

      Volume: 460 Issue: 3 Pages: 271

    • DOI

      10.1007/s00428-012-1201-7

    • URL

      https://pure.teikyo.jp/en/publications/fdc8d4e3-0455-4a87-9e2c-09dc73ce6a5e

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARID1A expression loss in gastric cancer: Pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability2012

    • Author(s)
      Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K,Kunita A, Ushiku T, Uozaki H,Tateishi Y, Hishima T, Iwasaki Y, Ishikawa S, Fukayama M
    • Journal Title

      Virchows Archiv

      Volume: 461 Issue: 4 Pages: 367

    • DOI

      10.1007/s00428-012-1303-2

    • URL

      https://pure.teikyo.jp/en/publications/3a3188e5-1ae2-4185-810d-2d3195c38fa6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation Epigenotypes2011

    • Author(s)
      Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M.
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 7187-97

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-associated gastric carcinoma2011

    • Author(s)
      Fukayama M and Ushiku T.
    • Journal Title

      Pathol Res Pract

      Volume: 207(9) Pages: 529-37

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis2011

    • Author(s)
      Ushiku T, Matsusaka K, Iwasaki Y, Tateishi Y, Funata N, Seto Y, Fukayama M.
    • Journal Title

      Histopathology

      Volume: 59(6) Pages: 1081-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【病理診断に役立つ分子生物学】(第2部)病理診断医になじみのある疾患関連分子EBER(EBV-encodedsmallRNA)・EBNA(EBV-determinednuclearantigen)解説編2011

    • Author(s)
      日野るみ,深山正久
    • Journal Title

      病理と臨床

      Volume: 29 Pages: 217-2215

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【病理診断に役立つ 分子生物学】 (第 2 部)病理診断医になじみ のある疾患関連分子 EBER(EBV-encoded small RNA)・EBNA(EBV-determined nuclear antigen) 診断編2011

    • Author(s)
      日野るみ , 深山正久
    • Journal Title

      病理と臨床

      Volume: 29 Pages: 222-224

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro2010

    • Author(s)
      Morikawa T, Hino R, Uozaki H, Maeda D, Ushiku T, Shinozaki A, Sakatani T, Fukayama M.
    • Journal Title

      Hum Pathol

      Volume: 41(12) Pages: 1742-1748

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of microRNA-200 inEBV-associated gastric carcinoma2010

    • Author(s)
      Shinozaki A, Sakatani T, Ushiku T, HinoR, Isogai M, Ishikawa S, Uozaki H, TakadaK, Fukayama M.
    • Journal Title

      Cancer Res

      Volume: 70(11) Pages: 4719-4127

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus and gastric carcinoma2010

    • Author(s)
      Fukayama M.
    • Journal Title

      Pathol Int

      Volume: 60(5) Pages: 337-50

    • NAID

      10029331697

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Epstein-Barrvirus関連胃癌及び非関連胃癌におけるARID1A発現消失の臨床病理学的検討2012

    • Author(s)
      阿部浩幸,前田大地,日野るみ,深山正久
    • Organizer
      第9回EBウイルス研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription Factor SOX9 in Gastric Cancer2012

    • Author(s)
      Sun M, Uozaki H, Kunita A, Hino R, Ushiku T, Hibiya T, Fukayama M et al
    • Organizer
      東京大学グローバル COE 疾患のケミカルバイオロジー教育研究拠点 第4回リトリートおよび国際シンポジウム
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV 関連胃癌のDNAメチル化 機構における SOCS3, STAT3/ DNMT12012

    • Author(s)
      日野るみ
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 深山正久Epstein-Barrvirus関連胃癌及び非関連胃癌におけるARID1A発現消失の臨床病理学的検討2012

    • Author(s)
      阿部浩幸,前田大地,日野るみ
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV関連胃癌のDNAメチル化機構におけるSOCS-3, STAT3/DNMT1経路の関与2012

    • Author(s)
      日野るみ
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京 京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胃癌の病理,EBウイルス関連胃癌の研究を通して2011

    • Author(s)
      深山正久
    • Organizer
      第43回藤田学園医学会
    • Place of Presentation
      藤田保健衛生大学愛知
    • Year and Date
      2011-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV関連胃癌のDNAメチル化機構におけるSOCS-3, STAT3/DNMT1経路の関与2011

    • Author(s)
      日野るみ
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] EBウイルス関連胃癌におけるmicroRNA-141の発現と,発現制御機構としてのメチル化の関係2011

    • Author(s)
      日比谷孝志,坂谷貴司,篠崎綾,孫敏華,日野るみ,牛久哲男,磯貝まや,石川俊平,宇於崎宏,深山正久
    • Organizer
      第8回EBウイルス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] EBウイルス関連胃癌におけるエピジェネティクス異常2011

    • Author(s)
      日野るみ
    • Organizer
      第100回日本病理学会総会ワークショップ
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌剖検例における Pulmonary tumor thrombotic microangiopathy の病理組織学的検 討2011

    • Author(s)
      阿部浩幸, 日 野るみ , 深山 正久
    • Organizer
      第100回 病理学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌に おける SOX2 と SOX9 蛋白質の消失 進行ステージと EBV 感染との関連(Loss of SOX2 and SOX9 protein in gastric cancers: correlation with the stages and EBV infection)2011

    • Author(s)
      孫敏華, 宇於崎宏, 日野るみ , 篠崎綾, 日比谷孝志, 牛久哲男, 深山正久
    • Organizer
      第100回病理学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] 深山正久EB ウイルス関連胃癌における microRNA-21とProgrammed cell death 4 発現の検討2011

    • Author(s)
      日比谷孝志, 坂谷貴司, 篠崎綾, 孫敏華, 日野るみ ,牛久哲男,磯貝まや,石川俊平,宇於崎宏
    • Organizer
      第100回病理学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] 粘膜内印環細胞癌からスキルス胃癌への進展様式2011

    • Author(s)
      六反啓文,牛久哲男,日野るみ,篠崎綾,深山正久
    • Organizer
      第100回病理学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] 感染・炎症と胃癌EBウイルス関連胃癌の場合2011

    • Author(s)
      深山正久
    • Organizer
      第100回病理学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV関連胃癌のDNAメチル化機構におけるSOCS-32011

    • Author(s)
      日野るみ,宇於崎宏,深山正久
    • Organizer
      STAT3/DNMT1経路の関与第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌剖検例におけるPulmonary tumor thrombotic microangiopathyの病理組織学的検討2011

    • Author(s)
      阿部浩幸, 日野るみ, 石川俊平, 深山正久
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Related Report
      2012 Final Research Report
  • [Presentation] Epstein-Barr virus and gastric carcinoma. Seoul Pathology Forum2011

    • Author(s)
      Fukayama M.
    • Organizer
      Seoul National University Hospital (Seoul)
    • Place of Presentation
      Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Epstein-Barr virus and gastric carcinoma2011

    • Author(s)
      Fkayama M.
    • Organizer
      China-Japan Cancer Conference
    • Place of Presentation
      折円田 lRiverside Hotel (Shanghai) China
    • Related Report
      2012 Final Research Report
  • [Presentation] EBウイルス陽性胃癌-高頻度DNAメチル化異常について-2010

    • Author(s)
      日野るみ
    • Organizer
      平成22年度遺伝子病制御研究所研究集会
    • Place of Presentation
      北海道大学医学部フラテ会館(北海道)
    • Year and Date
      2010-12-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 感染症と癌-EBウイルス関連胃癌2010

    • Author(s)
      深山正久
    • Organizer
      第27回関東臨床免疫懇話会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] EBウイルス陽性胃癌-高頻度DNAメチル化異常について-平成22年度2010

    • Author(s)
      日野るみ
    • Organizer
      遺伝子病制御研究所研究集会「感染,炎症,発癌」
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2012 Final Research Report
  • [Book] Gastric Cancer2010

    • Author(s)
      Fukayama M, Shinozaki A, Hino R.
    • Publisher
      Wolters kluwer/Lippincott Williams & Wiilkins, Advances in Surgical Pathology
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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