Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer

• Project/Area Number: 22590311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Shinshu University
• Principal Investigator: SHIMOJO Hisashi 信州大学, 医学部, 助教 (40324248)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137) ; FUKUSHIMA Mana 金沢医科大学, 医学部, 助教 (70546225)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 泌尿生殖器 / 癌 / 糖鎖 / 前立腺癌

Research Abstract

We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.

Research Products

• [Journal Article] Reduced glycosylation ofα-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer (2011)
  • Author(s): Shimojo H, Kobayashi M, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J
  • Journal Title: Prostate Volume: 71 Issue: 11 Pages: 1151-1157
  • DOI: 10.1002/pros.21330
  • Peer Reviewed
• [Presentation] 前立腺癌におけるα-ジストログリカン糖鎖と浸潤性増殖パターンとの関連 (2011)
  • Author(s): 下条久志、小林基弘、中山淳
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-29
• [Presentation] Reduced Glycosylation of α-Dystroglycans on Carcinoma Cells Contributes to Formation of Highly Infiltrative Histological Patterns in Prostate Cancer. (2010)
  • Author(s): Shimojo H, Kobayashi M, Fukuda M, Nakayama J.
  • Organizer: 2010 Annual Conference of the Society for Glycobiology (2010年糖鎖生物学会)
  • Place of Presentation: タンパ(フロリダ、米国)
  • Year and Date: 2010-11-09
• [Presentation] Reduced Glycosylation of a-Dystroglycans on Carcinoma Cells Contributes to Formation of Highly Infiltrative Histological Patterns in Prostate Cancer (2010)
  • Author(s): 下条久志
  • Organizer: 2010年糖鎖生物学会(2010 Annual Conference of the Society for Glycobiology)
  • Place of Presentation: タンパ(フロリダ)
  • Year and Date: 2010-11-09