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Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer

Research Project

Project/Area Number 22590311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionShinshu University

Principal Investigator

SHIMOJO Hisashi  信州大学, 医学部, 助教 (40324248)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Motohiro  信州大学, 医学系研究科, 講師 (00362137)
FUKUSHIMA Mana  金沢医科大学, 医学部, 助教 (70546225)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords泌尿生殖器 / 癌 / 糖鎖 / 前立腺癌
Research Abstract

We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Reduced glycosylation ofα-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer2011

    • Author(s)
      Shimojo H, Kobayashi M, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J
    • Journal Title

      Prostate

      Volume: 71 Issue: 11 Pages: 1151-1157

    • DOI

      10.1002/pros.21330

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 前立腺癌におけるα-ジストログリカン糖鎖と浸潤性増殖パターンとの関連2011

    • Author(s)
      下条久志、小林基弘、中山淳
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Reduced Glycosylation of α-Dystroglycans on Carcinoma Cells Contributes to Formation of Highly Infiltrative Histological Patterns in Prostate Cancer.2010

    • Author(s)
      Shimojo H, Kobayashi M, Fukuda M, Nakayama J.
    • Organizer
      2010 Annual Conference of the Society for Glycobiology (2010年糖鎖生物学会)
    • Place of Presentation
      タンパ(フロリダ、米国)
    • Year and Date
      2010-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduced Glycosylation of a-Dystroglycans on Carcinoma Cells Contributes to Formation of Highly Infiltrative Histological Patterns in Prostate Cancer2010

    • Author(s)
      下条久志
    • Organizer
      2010年糖鎖生物学会(2010 Annual Conference of the Society for Glycobiology)
    • Place of Presentation
      タンパ(フロリダ)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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