Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer
Project/Area Number |
22590311
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Shinshu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137)
FUKUSHIMA Mana 金沢医科大学, 医学部, 助教 (70546225)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 泌尿生殖器 / 癌 / 糖鎖 / 前立腺癌 |
Research Abstract |
We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.
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Report
(4 results)
Research Products
(4 results)