Comprehensive analyses of epigenetic abnormalities inadult T-cell leukemia/lymphoma (ATLL)
| Project/Area Number |
22590312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Okayama University |
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Principal Investigator |
OKA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (50160651)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Tasashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70183704)
OUCHIDA Mamoru 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80213635)
佐藤 妃映 岡山大学, 大学院・保健学研究科, 助教 (70362960)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ATL / マイクロアレイ / エピジェネテイックス / miRNA / ポリコーム / ヒストン修飾 / DNAメチル化 / 悪性リンパ腫 / エピジェネティックス / 白血病 / ATLL / HTLV-I / メチル化 |
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| Research Abstract |
We investigated the epigenetic mechanism of onset and progression of non-Hodgikinlymphoma as well as adult T-cell leukemia/lymphoma (ATLL). We found that epigenetic abnormalities including unbalanced expression of Polycomb Repressive Complex (PRC) molecules, aberrant expression of miRNA and mRNA and also aberrant DNA methylation are playing the important role in the pathogenesis of ATLL.
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy.2012
Author(s)
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T
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Journal Title
Virchows Arch
Volume: 462(2)
Pages: 219-228
Related Report
Peer Reviewed
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[Journal Article] Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics2012
Author(s)
Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Mami Tokunaka, Yukari Miki,Yara Yukie Kikuti2, Kazuhiko Igarashi4, Etsuro Ito, Hideo Harigae, Seiichi Kato,Eiko Hayashi, Takashi Oka, Yoshinobu Hoshii, Akira Tari, Hiroyuki Okada,Abd Alkader Lamia Mohamad, Yoshinobu Maeda, Mitsune Tanimoto,Tomohiro Kinoshita and Tadashi Yoshino
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Journal Title
Modern Pathology
Volume: 26
Pages: 22-31
NAID
Related Report
Peer Reviewed
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[Journal Article] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma (ATLL).2010
Author(s)
Hiaki Sato, Takashi Oka, Yoko Shinnou, Takami Kondo, Kana Washio, Masayuki Takano, Katsuyoshi Takata, Toshiaki Morito, Xingang_Huang, Maiko Tamura, Yuta Kitamura, Nobuya Ohara, Mamoru Ouchida, Koichi Ohshima, Kenji Shimizu, Mitsune Tanimoto, Kiyoshi Takahashi, Masao Matsuoka, Atae Utsunomiya, Tadashi Yoshino
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Journal Title
Ame.J Pathol
Volume: 176(1)
Pages: 402-415
Related Report
Peer Reviewed
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[Presentation] Dynamic changes of epigenetic abnormalities during initiation and progression of adult T-cell leukemia/lymphoma (ATLL)2012
Author(s)
Takashi Oka*, Lamia Abd Al-Kader, Hiaki Sato, Kana Washio, Yoko Shinnou, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida and Tadashi Yoshino
Organizer
American Association of Cancer Research (AACR) Annual Meeting 2012
Place of Presentation
Chicago, Illinois, USA
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[Presentation] Aberrant expression of PcG proteins in Non-Hodgkin B- and T-Cell Lymphoma: A relation to aggressive sub-types2011
Author(s)
Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Akihiro Manabe, Tomohiro Toji, Ichiro Murakami, Mamoru Ouchida,Hiroshi Kimura, Otte AP and Tadashi Yoshino
Organizer
The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL)2011
Author(s)
Takashi Oka, Hiaki Sato, Lamia Abd Al-Kader, Yoko Shinnou, Kana Washio, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Ouchida, Kiyoshi Takahashi and Tadashi Yoshino
Organizer
15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
Place of Presentation
Leuven, Belgium
Related Report
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[Presentation] Cumulative kinetics of epigenetic abnormalities during initiation and progression of Adult T-cell Leukemia/Lymphoma (ATLL)2011
Author(s)
Takashi Oka, Hiaki Sato, Lamia Abd Al-Kader, Yoko Shinnou, Kana Washio, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya, Mamoru Oucchida, Kiyoshi Takahashi, Tadashi Yoshino
Organizer
15th International Conference on Human Retrovirology : HTLV and Related Retroviruses
Place of Presentation
ベルギー、ルーベン
Related Report
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[Presentation] Aberrant expression of PcG proteins in Non-Hodgkin B- and T-Cell Lymphoma : A relation to aggressive sub-types2011
Author(s)
Lamia Abd Al-Kader, Takashi Oka, Katsuyoshi Takata, Xu Sun, Hiaki Sato, Akihiro Manabe, Tomohiro Toji, Ichiro Murakami, Mamoru Ouchida, Hiroshi Kimura, Otte AP, Tadashi Yoshino
Organizer
The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
Place of Presentation
Tokyo
Related Report
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[Presentation] Development and progression of gastric MALT lymphoma are associated with accumulation of specific aberrant CpG hypermethylation by Helicobacter pylori infection2010
Author(s)
Takashi Oka1), Takami Kondo1), Hiaki Sato3), Yoko Shinnou1), Kana Washio1), Ichirou Murakamni1), ABD AL-Kader Lamia1), Xu Sun1), Katsuyoshi Takata1), Mamoru Ohuchida2), Tadashi Yoshino1)
Organizer
Epigenetics研究会
Place of Presentation
米子
Year and Date
2010-05-28
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[Presentation] Multi-step accumulation of aberrant CpG island hypermethylation during progression of lymphoma/leukemia2010
Author(s)
Takashi Oka, Takami Kondo, Hiaki Sato, Yoko Nakatani, Kana Washio, Ichiro Murakami, Nobuya Ohara, Kiyoshi Takahashi, Mamoru Ouchida,Mitsune Tanimoto,Tadashi Yoshino
Organizer
15th World Congress on Advances in Oncology, 13th International Symposium on Molecular Medicine
Place of Presentation
Loutraki, Greece
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