Pathological studies on molecular basis of failure of vascular homeostasis and pathological vascular remodeling.
| Project/Area Number |
22590315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Takaomi 九州大学, 大学病院, 講師 (70380615)
OKANO Shinji 九州大学, 大学病院, 臨床助教 (10380429)
ONIMARU Mitsuho 九州大学, 大学院・医学研究院, 助教 (00380626)
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| Co-Investigator(Renkei-kenkyūsha) |
SUEISHI Katsuo 国立病院機構福岡東医療センター (70108710)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 病理学 / 発現制御 / 循環器 / 血管新生 / 動脈硬化 / 血管リモデリング / 内皮細胞 / VEGF / 脈管新生 / シグナル伝達 / 脂質沈着 / 血管平滑筋細胞 / センダイウイルス / Tie1 / ポドプラニン / シェディング |
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| Research Abstract |
To elucidate the molecular basis of pathological vascular remodeling, we investigated on atherosclerosis, vasculitis, and angiogenic diseases (tumor, diabetes mellitus). We found that, various factors, which concerned with angio- and lymph-angiogenesis, inflammation, innate immunity , control the vascular integrity by genetic and biochemical level. The failure of vascular homeostasis lead to loss of vascular integrityand modification of cell function, result in pathological vascular remodeling.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites2011
Author(s)
Sugiyama M, Kakeji Y, Tsujitani S, Harada Y, Onimaru M, Yoshida K, Tanaka S, Emi Y, Morita M, Morodomi Y, Hasegawa M, Maehara Y, Yonemitsu Y
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Journal Title
Mol Cancer Ther
Volume: 10
Issue: 3
Pages: 540-549
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Urokinase-Targeted Fusion by Oncolytic Sendai Virus Eradicates Orthotopic Glioblastomas by Pronounced Synergy With Interferon-beta Gene2010
Author(s)
Hasegawa Y, Kinoh H, Iwadate Y,Onimaru M, Ueda Y, Harada Y, Saito S, Furuya A, Saegusa T, Morodomi Y, Hasegawa M, Saito S, Aoki I, Saeki N, Yonemitsu Y
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Journal Title
Mol Ther
Volume: 18(10)
Issue: 10
Pages: 1778-86
DOI
Related Report
Peer Reviewed
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