| Project/Area Number |
22590315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Takaomi 九州大学, 大学病院, 講師 (70380615)
OKANO Shinji 九州大学, 大学病院, 臨床助教 (10380429)
ONIMARU Mitsuho 九州大学, 大学院・医学研究院, 助教 (00380626)
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| Co-Investigator(Renkei-kenkyūsha) |
SUEISHI Katsuo 国立病院機構福岡東医療センター (70108710)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 病理学 / 発現制御 / 循環器 / 血管新生 / 動脈硬化 / 血管リモデリング / 内皮細胞 / VEGF / 脈管新生 / シグナル伝達 / 脂質沈着 / 血管平滑筋細胞 / センダイウイルス / Tie1 / ポドプラニン / シェディング |
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| Research Abstract |
To elucidate the molecular basis of pathological vascular remodeling, we investigated on atherosclerosis, vasculitis, and angiogenic diseases (tumor, diabetes mellitus). We found that, various factors, which concerned with angio- and lymph-angiogenesis, inflammation, innate immunity , control the vascular integrity by genetic and biochemical level. The failure of vascular homeostasis lead to loss of vascular integrityand modification of cell function, result in pathological vascular remodeling.
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