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Analysis of DNA methylation of isolated glands in gastric cancers and the surrounding the intestinal glands and non -intestinal glands

Research Project

Project/Area Number 22590317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionIwate Medical University

Principal Investigator

SUGAI Tamotsu  岩手医科大学, 医学部, 教授 (20187628)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords胃 / 腸上皮化生 / メチル化 / 腺管分離 / Epigenetics
Research Abstract

The crypt isolation technique was used to analysis methylation of tumor related genes of non-metaplastic g astric gland (NM), intestinal metaplasia gland (IM) and gastric cancer gland (GC). NM, IM and GC specimens were obtained from 35 patients with gastric cancer (intestinal type [n=22], diffuse type [n=13]). Three samples were obtained from cancer, antrum and body. After crypt isolation of each sample, the non-cancerous glands were classified into NM glands, incomplete intestinal metaplasia gland (IIM) and complete intestinal metaplasia gland (CIM) by double stain methods of alcian blue and MUC5AC immnostain. These samples were examined CpG island hypermethylation by Combine Bislufite Restriction Analysis (COBRA) for 8 genes (MLH1 , p16 , HPP1, RUNX3 , ZFP64 , RASSF2A, SFRP1, E-cadherin). IIM and CIM gland have significant higher methylation than NM gland. But, IIM and CIM had no significant differences in methylation status. The methylation GC gland and diffuse type GC gland had no significant differences. The methylation level of GC gland was significantly higher than corresponding NM gland, but no difference was observed in corresponding IM gland. The present data on NM gland, GIM gland and GC gland suggest that genetic alternations already occur within the surrounding noncancerous glands.status of intestinal type .

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (123 results)

All 2013 2012 2011 2010

All Journal Article (79 results) (of which Peer Reviewed: 46 results) Presentation (42 results) Book (2 results)

  • [Journal Article] Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.2013

    • Author(s)
      Sawada T, Yamamoto E, Suzuki H
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 52(2) Issue: 2 Pages: 140-9

    • DOI

      10.1002/gcc.22013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃腺腫と腫瘍グレードに基づいた分化型粘膜内胃癌の臨床病理学的および分子病理学的解析2012

    • Author(s)
      菅井 有,幅野 渉,上杉憲幸(以下9名)
    • Journal Title

      胃と腸

      Volume: 47(2) Pages: 203-16

    • Related Report
      2012 Final Research Report
  • [Journal Article] 発生部位に基づいた大腸癌の分子解析と背景粘膜のDNAメチル化異常2012

    • Author(s)
      菅井 有,幅野 渉,吉田雅一(以下9名)
    • Journal Title

      胃と腸

      Volume: 47(13) Pages: 1935-46

    • Related Report
      2012 Final Research Report
  • [Journal Article] SSA/Pと粘液性状と遺伝子解析2012

    • Author(s)
      菅井 有,上杉憲幸,石田和之(以下5名)
    • Journal Title

      消化器内視鏡

      Volume: 24(7) Pages: 1119-27

    • Related Report
      2012 Final Research Report
  • [Journal Article] SSA/Pは腫瘍なのか,非腫瘍なのか?(1)腫瘍と考える立場から.2012

    • Author(s)
      菅井 有,幅野 渉,山野泰穂,山本英一郎,鈴木 拓
    • Journal Title

      INTESTINE

      Volume: 16(6 Pages: 485-92

    • Related Report
      2012 Final Research Report
  • [Journal Article] BRAF変異を有する右側発生のMSS型癌の予後は不良である!2012

    • Author(s)
      菅井 有
    • Journal Title

      病理と臨床

      Volume: 30(11) Pages: 1273-75

    • Related Report
      2012 Final Research Report
  • [Journal Article] 大腸鋸歯状病変の臨床病理および分子異常鋸歯状経路の意義2012

    • Author(s)
      菅井 有, 幅野 渉,石田和之(以下6名)
    • Journal Title

      大腸癌FRONTIER

      Volume: 5(4) Pages: 308-15

    • Related Report
      2012 Final Research Report
  • [Journal Article] 粘液形質にもとづいた胃粘膜内癌および周囲腸上皮化生の分子異常2012

    • Author(s)
      菅井 有, 幅野 渉, 遠藤昌樹(以下5名)
    • Journal Title

      Helicobacter Research.

      Volume: 16(2) Pages: 111-18

    • Related Report
      2012 Final Research Report
  • [Journal Article] Overexpre ssion of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells.2012

    • Author(s)
      Kanno K, Kanno S, Nitta H, Uesugi N, Sugai T, Masuda T, Wakabayashi G , Maesawa C
    • Journal Title

      Oncol Rep.

      Volume: 28(3) Issue: 3 Pages: 867-73

    • DOI

      10.3892/or.2012.1898

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Colonic mucosa -associated lymphoid tissue lymphoma.2012

    • Author(s)
      Akasaka R, Chiba T , Dutta AK.
    • Journal Title

      Case Rep Gastroenterol.

      Volume: 6(2) Issue: 2 Pages: 569-75

    • DOI

      10.1159/000342726

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The application of Methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells2012

    • Author(s)
      Seiya Yokoyama
    • Journal Title

      BMC Cancer

      Volume: 12(In press) Issue: 1 Pages: 67-67

    • DOI

      10.1186/1471-2407-12-67

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma.2012

    • Author(s)
      Kimura T, Yamamoto E, Yamano HO.
    • Journal Title

      Am J Gastroenterol.

      Volume: 107(3) Issue: 3 Pages: 460-9

    • DOI

      10.1038/ajg.2011.457

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of serrated adenocarcinoma defined by Makinen in dukes' B colorectal carcinoma.2012

    • Author(s)
      Shida Y, Fujimori T , Tanaka H
    • Journal Title

      Pathobiology

      Volume: 79(4) Pages: 169-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Dissection of Premalignant Colorectal Lesions Reveals Early Onset of the CpG Island Methylator Phenotype.2012

    • Author(s)
      Yamamoto E, Suzuki H, Yamano HO
    • Journal Title

      Am J Pathol

      Volume: 181(5) Issue: 5 Pages: 1847-61

    • DOI

      10.1016/j.ajpath.2012.08.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using image processing software analysis for Ki67 immunohistochemistry.2012

    • Author(s)
      Fujimori Y, Fujimori T, Imura J.
    • Journal Title

      Diagn Pathol

      Volume: 7 Issue: 1 Pages: 59-59

    • DOI

      10.1186/1746-1596-7-59

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.2012

    • Author(s)
      Ishida K, Nishiduka S, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N,Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.
    • Journal Title

      PLoS One

      Volume: 7(8) Issue: 8 Pages: e43236-e43236

    • DOI

      10.1371/journal.pone.0043236

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Desmoplastic reaction in biopsy specimens of early colorectal cancer: a Japanese prospective multicenter study.2012

    • Author(s)
      Kimura R, Fujimori T, Ichikawa K
    • Journal Title

      Pathol Int

      Volume: 62(8) Issue: 8 Pages: 525-31

    • DOI

      10.1111/j.1440-1827.2012.02840.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer.2012

    • Author(s)
      Takamaru H, Yamamoto E, Suzuki H.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 5(10) Issue: 10 Pages: 2012-2012

    • DOI

      10.1158/1940-6207.capr-12-0056

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃腺腫と腫瘍グレードに基づいた分化型粘膜内胃癌の臨床病理学的および分子病理学的解析.2012

    • Author(s)
      菅井 有
    • Journal Title

      胃と腸

      Volume: 47 Pages: 203-216

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 発生部位に基づいた大腸癌の分子解析と背景粘膜のDNAメチル化異常.2012

    • Author(s)
      菅井 有
    • Journal Title

      胃と腸

      Volume: 47 Pages: 1935-1946

    • Related Report
      2012 Annual Research Report
  • [Journal Article] SSA/Pと粘液性状と遺伝子解析.2012

    • Author(s)
      菅井 有
    • Journal Title

      消化器内視鏡

      Volume: 24 Pages: 1119-1127

    • Related Report
      2012 Annual Research Report
  • [Journal Article] SSA/Pは腫瘍なのか,非腫瘍なのか?(1)腫瘍と考える立場から.2012

    • Author(s)
      菅井 有
    • Journal Title

      INTESTINE

      Volume: 16 Pages: 485-492

    • Related Report
      2012 Annual Research Report
  • [Journal Article] BRAF変異を有する右側発生のMSS型癌の予後は不良である!2012

    • Author(s)
      菅井 有
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 1273-1275

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 大腸癌FRONTIER2012

    • Author(s)
      菅井 有
    • Journal Title

      大腸鋸歯状病変の臨床病理および分子異常―鋸歯状経路の意義―.

      Volume: 5 Pages: 308-315

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Helicobacter Research2012

    • Author(s)
      菅井 有
    • Journal Title

      粘液形質にもとづいた胃粘膜内癌および周囲腸上皮化生の分子異常.

      Volume: 16 Pages: 111-118

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Colonic mucosa-associated lymphoid tissue lymphoma. Case Rep Gastroenterol.2012

    • Author(s)
      Akasaka R
    • Journal Title

      Case Rep Gastroenterol

      Volume: 6 Pages: 569-575

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of serrated adenocarcinoma defined by Mäkinen in dukes' B colorectal carcinoma.2012

    • Author(s)
      Shida Y
    • Journal Title

      Pathobiology

      Volume: 79 Issue: 4 Pages: 169-174

    • DOI

      10.1159/000334837

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃腺腫と腫瘍グレードに基づいた分化型粘膜内胃癌の臨床病理学的および分子病理学的解析2012

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 47 Pages: 203-216

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 大腸鋸歯状病変の臨床病理学的特徴および分子病理学的意義2011

    • Author(s)
      菅井 有,山野泰穂,木村友昭(以下3名)
    • Journal Title

      胃と腸

      Volume: 46(4) Pages: 373-83

    • Related Report
      2012 Final Research Report
  • [Journal Article] Gastrointestinal Stromal Tumor(GIST)の臨床病理と最近の進歩2011

    • Author(s)
      菅井 有,上杉憲幸,山田範幸(以下5名)
    • Journal Title

      癌と化療

      Volume: 38(5) Pages: 715-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] 消化管の病理II-下部消化管- 鋸歯状病変の病理診断および分子病理学的特徴2011

    • Author(s)
      菅井 有,山野泰穂,木村友昭(以下3名).
    • Journal Title

      病理と臨

      Volume: 29(10) Pages: 1065-1070

    • Related Report
      2012 Final Research Report
  • [Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.2011

    • Author(s)
      Habano W, Gamo T, Tearashima J
    • Journal Title

      BMC Cancer

      Volume: 11 Issue: 1 Pages: 81-81

    • DOI

      10.1186/1471-2407-11-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.2011

    • Author(s)
      Pandey P, Okuda H, Watabe M.
    • Journal Title

      Breast Can Res Treat

      Volume: 130(2) Issue: 2 Pages: 387-98

    • DOI

      10.1007/s10549-010-1300-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigen etic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.2011

    • Author(s)
      Kamimae S, Yamamoto E, Yamano H.
    • Journal Title

      Cancer Prev Res (Phila) .

      Volume: 4 Pages: 674-683

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma.2011

    • Author(s)
      Nakamura Y, Nagashima H, Akiyaka M.
    • Journal Title

      Int Arch Allergy Imm.

      Volume: 155 Issue: 2 Pages: 129-40

    • DOI

      10.1159/000319826

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大腸鋸歯状病変の臨床病理学的特徴および分子病理学的意義2011

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 46 Pages: 373-383

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Gastrointestinal Stromal Tumor(GIST)の臨床病理と最近の進歩2011

    • Author(s)
      菅井有
    • Journal Title

      癌と化療

      Volume: 38 Pages: 715-721

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 鋸歯状病変の病理診断および分子病理学的特徴2011

    • Author(s)
      菅井有
    • Journal Title

      病理と臨

      Volume: 29 Pages: 1065-1070

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011

    • Author(s)
      Habano W
    • Journal Title

      BMC Cancer

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase2011

    • Author(s)
      Pandey P
    • Journal Title

      Breast.Can.Res.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Proton Pump Inhibitors in Patients with Laryngopharyngeal Reflux Disease2011

    • Author(s)
      Chiba T
    • Journal Title

      Hepatogastroenterology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors2011

    • Author(s)
      Kamimae S
    • Journal Title

      Cancer.Prevent.Res

      Volume: 4 Pages: 674-83

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma2011

    • Author(s)
      Nakamura Y
    • Journal Title

      Int.Arch.Allergy.Imm

      Volume: 155 Pages: 129-40

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.2011

    • Author(s)
      Pandey P
    • Journal Title

      Breast Can.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.2011

    • Author(s)
      Kamimae S
    • Journal Title

      Cancer Prevent Res

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.2011

    • Author(s)
      Habano W
    • Journal Title

      BMC Cancer

      Volume: 11(81)(Open access)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ribbon-type NFAT decoy oligodeoxynucleotides precludes airways hyperreactivity and Th2 cytokines expression in experimental asthma.2011

    • Author(s)
      Nakamura Y
    • Journal Title

      Int Arch Allergy Imm

      Volume: 155 Pages: 129-140

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer : a Japanese collaborarive study.2011

    • Author(s)
      Hirose M
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 1212-1218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床医のための分子生物学2010

    • Author(s)
      菅井 有,幅野 渉,鈴木一幸
    • Journal Title

      胃と腸

      Volume: 45(5) Pages: 710-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] 側方発育型大腸腫瘍の臨床病理学的および分子病理学的解析2010

    • Author(s)
      菅井 有,山野泰穂,高木 亮
    • Journal Title

      胃と腸

      Volume: 45(6) Pages: 939-52

    • Related Report
      2012 Final Research Report
  • [Journal Article] 鋸歯状病変2010

    • Author(s)
      菅井 有,山野泰穂,木村友昭
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 144-147

    • Related Report
      2012 Final Research Report
  • [Journal Article] -そこが知りたい消化管腫瘍病理- 深達度診断の標準化2010

    • Author(s)
      菅井 有,上杉憲幸,遠藤昌樹,千葉俊美.
    • Journal Title

      病理と臨床

      Volume: 28(6) Pages: 635-41

    • Related Report
      2012 Final Research Report
  • [Journal Article] 核異型度に基づいた腸型分化型胃粘膜内癌の分子病理学的解析2010

    • Author(s)
      菅井 有,幅野 渉,小西康弘(以下7名)
    • Journal Title

      胃と腸

      Volume: 45(7) Pages: 1212-25

    • Related Report
      2012 Final Research Report
  • [Journal Article] 遺伝性非ポリポーシス大腸癌の臨床病理と分子異常 孤発性MSI陽性大腸癌との比較2010

    • Author(s)
      菅井 有,上杉憲幸,幅野 渉(以下7名)
    • Journal Title

      胃と腸

      Volume: 45(13) Pages: 2065-78

    • Related Report
      2012 Final Research Report
  • [Journal Article] 大腸低分化腺癌の腫瘍発生と分子異常2010

    • Author(s)
      菅井 有,上杉憲幸,幅野 渉.
    • Journal Title

      胃と腸.

      Volume: 45(11) Pages: 1734-48

    • Related Report
      2012 Final Research Report
  • [Journal Article] Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa.2010

    • Author(s)
      Sugai T, Habano W, Jiao Y-F.
    • Journal Title

      Oncol Rep

      Volume: 23(1) Issue: 1 Pages: 25-33

    • DOI

      10.3892/or_00000602

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell cycle-related proteins in gastric intramucosal differentiatedtype cancers based on mucin phenotypes:anovel hypothesis of early gastric carcinogenesis based on mucin phenotype2010

    • Author(s)
      Sugai T, Tsukahara M, Endoh M
    • Journal Title

      BMC Gastroenterol.

      Volume: 10 Issue: 1 Pages: 55-55

    • DOI

      10.1186/1471-230x-10-55

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of gastric deifferentiated-type intramucosal and submucosal cancers.2010

    • Author(s)
      Sugai T, Habano W, Endoh M
    • Journal Title

      Int J Cancer

      Volume: 127 Issue: 11 Pages: 2500-9

    • DOI

      10.1002/ijc.25271

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in cell cycle-related protein expression and mucin phenotypes associated with the transition from adenoma to carcinoma in colorectal cancer2010

    • Author(s)
      Mue Y, Sugai T, Chiba T.
    • Journal Title

      J Iwate Med Assoc

      Volume: 62(4) Pages: 275-289

    • NAID

      110007699826

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation associated silencing of microRNA-34b/c in gastric cancer and its involvement in epigenetic field defect.2010

    • Author(s)
      Suzuki H, Yamamoto E, Nojima M
    • Journal Title

      Carcinogenesis.

      Volume: 31 Issue: 12 Pages: 2066-73

    • DOI

      10.1093/carcin/bgq203

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study.2010

    • Author(s)
      Hirose M, Fukui H, Igarashi Y
    • Journal Title

      J Gastroenterol.

      Volume: 45 Issue: 12 Pages: 1212-8

    • DOI

      10.1007/s00535-010-0288-3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefullness of endoscopic treatment for duodenal adenoma.2010

    • Author(s)
      Endo M, Abiko Y, Oana S
    • Journal Title

      Dig Endosc.

      Volume: 22(4) Issue: 4 Pages: 360-5

    • DOI

      10.1111/j.1443-1661.2010.01014.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010

    • Author(s)
      Yamashita M, Watanabe Y, et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Issue: 7 Pages: 1708-1716

    • DOI

      10.1111/j.1349-7006.2010.01581.x

    • NAID

      10026594987

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between tumor necrosis factor -alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease.2010

    • Author(s)
      Tomita K, Chiba T, Sugai T, Habano W.
    • Journal Title

      Hepato-Gastroenterology.

      Volume: 57(99-100) Pages: 535-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary retroperitoneal spindle cell liposarcoma: Pathological and immunohistochemical findings.2010

    • Author(s)
      Shioi Y, Hasegawa T, Otsuka K.
    • Journal Title

      Pathol Int.

      Volume: 60 Issue: 6 Pages: 472-6

    • DOI

      10.1111/j.1440-1827.2010.02541.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGFBP7 is a p53 -responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M
    • Journal Title

      Carcinogenesis.

      Volume: 31(3) Issue: 3 Pages: 342-9

    • DOI

      10.1093/carcin/bgp179

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation associated silencing of microRNA-34b/c in gastric cancer and its involvement in epigenetic field defect.2010

    • Author(s)
      Suzuki H
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 2066-2073

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefullness of endoscopic treatment for duodenal adenoma.2010

    • Author(s)
      Endo M
    • Journal Title

      Dig Endosc

      Volume: 22(4) Pages: 360-365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in cell cycle-related protein expression and mucin phenotypes associated with the transition from adenoma to carcinoma in colorectal cancer.2010

    • Author(s)
      Mue Y
    • Journal Title

      Iwate Med Assoc

      Volume: 62 Pages: 275-289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes : a novel hypothesis of early gastric carcinogenesis based on mucin phenotype.2010

    • Author(s)
      Sugai T
    • Journal Title

      BMC Gastroenterol

      Volume: 10(55)(Open accress)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010

    • Author(s)
      Yamashita M
    • Journal Title

      Cancer Sci

      Volume: 25 Pages: 2698-2701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between tumor necrosis factor-alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease.2010

    • Author(s)
      Tomita K
    • Journal Title

      Hepato Gastroenterol

      Volume: 57 Pages: 535-539

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis in gastric differentiated-type intramucosal and submucosal cancers.2010

    • Author(s)
      Sugai T
    • Journal Title

      Int J Cancer

      Volume: 127 Pages: 2500-2509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary retroperitoneal spindle cell liposarcoma : pathological and immunohistochemical findings2010

    • Author(s)
      Shioi Y
    • Journal Title

      Pathol Int

      Volume: 60(6) Pages: 472-476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床医のための分子生物学2010

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 45(5) Pages: 710-714

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 側方発育型大腸腫瘍の臨床病理学的および分子病理学的解析2010

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 45(6) Pages: 939-952

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 核異型度に基づいた腸型分化型胃粘膜内癌の分子病理学的解析2010

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 45(7) Pages: 1212-1225

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 大腸低分化腺癌の腫瘍発生と分子異常2010

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 45(11) Pages: 1734-1748

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 遺伝性非ポリポーシス大腸癌の臨床病理と分子異常 孤発性MSI陽性大腸癌との比較2010

    • Author(s)
      菅井有
    • Journal Title

      胃と腸

      Volume: 45(13) Pages: 2065-2078

    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸腺腫及び大腸癌における分子解析2012

    • Author(s)
      無江良晴
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 体腔液に出現する癌細胞におけるEMT関連蛋白発現の検討2012

    • Author(s)
      山田範幸
    • Organizer
      第53回日本臨床細胞学会総会春期大会
    • Place of Presentation
      千葉
    • Year and Date
      2012-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 264前立腺病変におけるAlpha-methylacyl-CoA racemase(AMACR/P504S)発現の検討2012

    • Author(s)
      遠藤則雄
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] ベセスダシステム異型腺細胞(AGC)の病理組織学的背景と課題2012

    • Author(s)
      安保淳一
    • Organizer
      第51回日本臨床細胞学会秋期大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃底腺癌の二例2012

    • Author(s)
      杉本 亮
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 分化型浸潤胃癌における浸潤に伴う形態および分子生物学的変化の検討2012

    • Author(s)
      鈴木正通
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] GIST診断に有用とされる新しい抗体の検討(第二報)2012

    • Author(s)
      高橋敬太
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸癌の病理学的評価はどの切片標本で行うべきか(第二報)2012

    • Author(s)
      小西康弘
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸癌における癌腺管と背景粘膜の非腫瘍性腺管のDNAメチル化解析2012

    • Author(s)
      吉田 雅一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸腺腫におけるメチル化解析2012

    • Author(s)
      無江良晴
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌肉腫におけるEMT関連蛋白発現の検討2012

    • Author(s)
      山田範幸
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃底腺癌の二例.2012

    • Author(s)
      杉本 亮
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分化型浸潤胃癌における浸潤に伴う形態および分子生物学的変化の検討.2012

    • Author(s)
      鈴木正通
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] GIST診断に有用とされる新しい抗体の検討(第二報)2012

    • Author(s)
      高橋敬太
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸癌の病理学的評価はどの切片標本で行うべきか(第二報).2012

    • Author(s)
      小西康弘
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸癌における癌腺管と背景粘膜の非腫瘍性腺管のDNAメチル化解析.2012

    • Author(s)
      吉田雅一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸腺腫におけるメチル化解析.2012

    • Author(s)
      無江良晴
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 癌肉腫におけるEMT関連蛋白発現の検討.2012

    • Author(s)
      山田範幸
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 体腔液に出現する癌細胞におけるEMT関連蛋白発現の検討.2012

    • Author(s)
      山田範幸
    • Organizer
      第53回日本臨床細胞学会総会春期大会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸腺腫及び大腸癌における分子解析.2012

    • Author(s)
      無江良晴
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベセスダシステム異型腺細胞(AGC)の病理組織学的背景と課題.2012

    • Author(s)
      安保淳一
    • Organizer
      第51回日本臨床細胞学会秋期大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] 64 前立腺病変におけるAlpha-methylacyl-CoA racemase(AMACR/P504S)発現の検討.2012

    • Author(s)
      遠藤則雄
    • Organizer
      第59回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] GIST診断マーカーとしてのDOG1, PDGF Receptor α, Carbonic Anhydrase 2, protein kinase C thetaの有用性2011

    • Author(s)
      山田範幸
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腺管分離法を用いた大腸癌背景粘膜のメチル化解析2011

    • Author(s)
      吉田雅一
    • Organizer
      第22回日本消化器癌発生学会総会
    • Place of Presentation
      佐賀
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 肺腺癌における免疫染色によるEGFR遺伝子変異の検討2011

    • Author(s)
      菊池いな子
    • Organizer
      第50回日本臨床細胞学会秋期大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 子宮頚部細胞診を契機に発見された腹膜原発漿液性乳頭状腺癌の一例2011

    • Author(s)
      冨澤静子
    • Organizer
      第52回日本臨床細胞学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 胃癌生検分類グループ分類の我々の考え方2011

    • Author(s)
      菅井 有
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 大腸腺腫におけるDNAメチル化解析2011

    • Author(s)
      無江良晴
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 新しい組織亜型分類に基づいた大腸低分化型腺癌の臨床病理学的検討2011

    • Author(s)
      上杉憲幸
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] CD10陽性大腸癌の分子病理学的特徴2011

    • Author(s)
      赤坂理三郎
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] マイクロサテライト安定性及びマイクロサテライト不安定性に基づいた子宮内膜癌の分子病理学的解析2011

    • Author(s)
      三浦自雄
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 大腸癌の病理学的評価はどの切片標本で行うべきか2011

    • Author(s)
      小西康弘
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] GIST診断マーカーとしてのDOG1, PDGF Receptor α, Carbonic Anhydrase 2, protein kinase C thetaの有用性.2011

    • Author(s)
      山田範幸
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌の早期浸潤過程におけるCXCR4蛋白過剰発現の意義についての免疫組織化学的解析2010

    • Author(s)
      上杉憲幸
    • Organizer
      第18回日本乳癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 腺管分離法を用いた胃癌腺管、腸上皮化生腺管、非化生腺管における癌関連遺伝子のメチル化解析2010

    • Author(s)
      小飯塚仁彦
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] CD10陽性大腸癌の分子生物学的特徴2010

    • Author(s)
      赤坂理三郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆嚢癌の分離腫瘍腺管と非腫瘍性胆嚢の分離上皮のメチル化解析2010

    • Author(s)
      塩井義裕
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸癌における固定時間および固定方法の違いによるVEGF -AおよびVEGFR2抗体の染色性の検討2010

    • Author(s)
      山田範幸
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸腺腫内癌における細胞周期関連蛋白と粘液形質の解析2010

    • Author(s)
      無江良晴
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 耳下腺に発生した硬化性多嚢包性腺症の一例2010

    • Author(s)
      小西康弘
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌の早期浸潤過程におけるCXCR4蛋白過剰発現の意義についての免疫組織化学的解析.2010

    • Author(s)
      上杉憲幸
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] GIST切除症例における臨床病理学的検討-治療に反映される病理学的指標の確率を目指して-2010

    • Author(s)
      上杉憲幸
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report
  • [Book] 腫瘍病理鑑別診断アトラス 大腸癌2011

    • Author(s)
      菅井 有,他
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 大腸非腺腫性大腸癌の病理 取り扱い規約に従った腫瘍鑑別診断アトラス 大腸2011

    • Author(s)
      菅井有
    • Publisher
      文光堂(印刷中)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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