Analysis of microRNA expression in pancreatic carcinogenesis.

• Project/Area Number: 22590318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Jichi Medical University
• Principal Investigator: FUKUSHIMA Noriyoshi 自治医科大学, 医学部, 教授 (40384937)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 膵管癌 / マイクロ RNA / 前癌病変 / 膵癌 / microRNA

Research Abstract

The aim of this study is to develop early diagnostic system of pancreatic cancer. The analyses of the early stage of pancreatic cancer, including pancreatic intraductal neoplasm have been performed. Total RNA from tissue specimens obtained by using microd

Research Products

• [Journal Article] IPMN 国際診療ガイドライン2012-残された課題-病理診断の判定基準-. (2013)
  • Author(s): 福嶋敬宜
  • Journal Title: 日本膵臓学会誌「膵臓」 Volume: 28巻2号 Pages: 156-161
  • Peer Reviewed
• [Journal Article] Multicenter study of serous cystic neoplasm of the Japan pancreas society (2012)
  • Author(s): Kimura W, Moriya T, Hanada K, Abe H, Yanagisawa A, Fukushima N
  • Journal Title: Pancreas Volume: 41(3) Pages: 380-7
  • Peer Reviewed
• [Journal Article] Comparison of CT findings of biliary tract changes with autoimmune pancreatitis and extrahepatic bile duct cholangiocarcinoma (2012)
  • Author(s): Maeda E, Akahane M, Fukushima N
  • Journal Title: Jpn J Radiol. Volume: 30(3) Pages: 227-34
  • NAID: 210000163116
  • Peer Reviewed
• [Journal Article] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression (2012)
  • Author(s): Mohri D, Asaoka Y, Ijichi H, Ohta M, Tada M, Tanaka Y, Ikenoue T, Tateishi K, Isayama H, Kanai F, Fukushima N
  • Journal Title: J Gastroenterol Volume: 47(2) Pages: 203-13
  • NAID: 10030296319
  • Peer Reviewed
• [Journal Article] 膵管内腫瘍の亜分類 (2012)
  • Author(s): 福嶋敬宜
  • Journal Title: 日消誌 Volume: 109巻2号 Pages: 173-7
  • NAID: 10030310291
  • Peer Reviewed
• [Journal Article] Multicenter study of serous cystic neoplasm of the Japan pancreas society. (2012)
  • Author(s): Kimura W，et al.
  • Journal Title: Pancreas Volume: 41 Issue: 3 Pages: 380-387
  • DOI: 10.1097/mpa.0b013e31822a27db
  • Peer Reviewed
• [Journal Article] Flow Cytometric Analysis of Kappa and Lambda Light Chain Expression in Endoscopic Biopsy Specimens before the Diagnosis of B-Cell Lymphoma (2012)
  • Author(s): Oka S, et al.
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 52 Issue: 2 Pages: 127-131
  • DOI: 10.3960/jslrt.52.127
  • NAID: 10031120437
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed
• [Journal Article] 膵漿液性嚢胞腫瘍（Serous cystic neoplasm）の全国症例調査―日本膵臓学会膵嚢胞性腫瘍委員会― (2012)
  • Author(s): 木村理，ほか
  • Journal Title: 膵臓 Volume: 27 Pages: 572-583
  • Peer Reviewed
• [Journal Article] IPMNの組織亜型（サブタイプ）分類の臨床病理学的意義． (2012)
  • Author(s): 福嶋敬宜
  • Journal Title: 外科 Volume: 75 Pages: 122-128
• [Journal Article] IPMNについての日本と欧米での考え方・取扱いの違い－病理の立場から． (2012)
  • Author(s): 福嶋敬宜
  • Journal Title: 胆と膵 Volume: 33 Pages: 1137-1140
• [Journal Article] 膵管内腫瘍の亜分類． (2012)
  • Author(s): 福嶋敬宜
  • Journal Title: 日本消化器病学会誌 Volume: 109 Pages: 173-177
  • NAID: 10030310291
• [Journal Article] Comparison of CT findings of biliary tract changes with autoimmune pancreatitis and extrahepatic bile duct cholangiocarcinoma (2012)
  • Author(s): Maeda E, et al
  • Journal Title: Jpn J Radiol Volume: 30 Issue: 3 Pages: 227-34
  • DOI: 10.1007/s11604-011-0035-6
  • Peer Reviewed
• [Journal Article] Claudin-18 is an Early-Stage Marker of Pancreatic Carcinogenesis (2011)
  • Author(s): Tanaka M, Shibahara J, Fukushima N
  • Journal Title: J Histochem Cytochem Volume: 59(10) Pages: 942-952
  • Peer Reviewed
• [Journal Article] Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma A Multi-Institutional Study of the Japan Pancreas Society. (2011)
  • Author(s): Yamao K, Yanagisawa A, Takahashi K, Kimura W, Doi R, Fukushima N
  • Journal Title: Pancreas Volume: 40 Pages: 67-71
  • Peer Reviewed
• [Journal Article] 胆膵腫瘍組織分類における癌取扱い規約と WHO 分類の異同と課題 (2011)
  • Author(s): 福嶋敬宜
  • Journal Title: 胆と膵 Volume: 32
• [Journal Article] Mucinous Cystic Neoplasm 悪性例の病理像および悪性頻度 (2011)
  • Author(s): 福嶋敬宜
  • Journal Title: 肝胆膵
• [Journal Article] 膵,WHO 新分類の Overview (2011)
  • Author(s): 福嶋敬宜
  • Journal Title: 肝胆膵 Volume: 62
• [Journal Article] Claudin-18 is an early-stage marker of pancreatic carcinogenesis (2011)
  • Author(s): Tanaka M, Shibahara J, Fukushima N, Shinozaki A, Umeda M, Ishikawa S, Kokudo N, Fukayama M
  • Journal Title: J Histochem Cytochem Volume: 59 Issue: 10 Pages: 942-952
  • DOI: 10.1369/0022155411420569
  • Peer Reviewed
• [Journal Article] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression (2011)
  • Author(s): Mohri D, et al
  • Journal Title: J Gastroenterol Volume: 47 Issue: 2 Pages: 203
  • DOI: 10.1007/s00535-011-0482-y
  • NAID: 10030296319
  • Peer Reviewed
• [Journal Article] 胆膵腫瘍組織分類における癌取扱い規約とWHO分類の異同と課題.:2011 (2011)
  • Author(s): 福嶋敬宜
  • Journal Title: 胆と膵 Volume: 32 Pages: 1271-1278
• [Journal Article] 2010年WHO新分類のOverview (2011)
  • Author(s): 福嶋敬宜
  • Journal Title: 肝胆膵 Volume: 62 Pages: 39-43
• [Journal Article] Undifferentiated Carcinoma of the Pancreas With/Without Osteoclast-like Giant Cells (2010)
  • Author(s): Tanaka M, Fukayama M, Fukushima N
  • Journal Title: Pathol Case Reviews Volume: 15(6) Pages: 210-214
  • Peer Reviewed
• [Journal Article] 膵の SCN と MCN の病理 (2010)
  • Author(s): 福嶋敬宜
  • Journal Title: 肝胆膵画像 Volume: 12 Pages: 687-692
• [Journal Article] 胆膵疾患における細胞診・生検診断の病理学的問題点 (2010)
  • Author(s): 福嶋敬宜
  • Journal Title: 胆と膵 Volume: 31 Pages: 815-818
• [Journal Article] Intraepithelial neoplasia (2010)
  • Author(s): 福嶋敬宜
  • Journal Title: 病理と臨床 Volume: 28巻 Pages: 174-175
• [Journal Article] 膵癌の前癌病変の病理 (2010)
  • Author(s): 福嶋敬宜
  • Journal Title: 肝胆膵画像 Volume: 12 Pages: 161-166
• [Journal Article] Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma : A Multi-Institutional Study of the Japan Pancreas Society. (2010)
  • Author(s): Yamao K, et al.
  • Journal Title: Pancreas Volume: 40 Pages: 67-71
  • Peer Reviewed
• [Journal Article] Undifferentiated Carcinoma of the Pancreas With/Without Osteoclast-like Giant Cells. (2010)
  • Author(s): Tanaka M, et al.
  • Journal Title: Pathol Case Reviews Volume: 15 Pages: 210-214
  • Peer Reviewed
• [Journal Article] Intraepithelial neoplasia (2010)
  • Author(s): 福嶋敬宜
  • Journal Title: 病理と臨床(臨時増刊号) Volume: 28 Pages: 174-175
• [Presentation] 早期膵癌・前駆病変研究における多分野連携の重要性と病理医の役割 -国際 CAPS サミットからの考察 (2013)
  • Author(s): 福嶋敬宜
  • Organizer: 第102回 日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-06-06
• [Presentation] International Consensus Study on the Terminology and Diagnosis of Tumoral Intraepithelial Neoplasms ("Adenomas" and "Intracystic Papillary Neoplasms" of WHO-2010) of the Gallbladder. (2013)
  • Author(s): Adsay V, et al.
  • Organizer: The 102nd The Annual Meeting of United State and Canadian Academy of Pathology
  • Place of Presentation: Baltimore, MD
• [Presentation] International Consensus Study on the Terminology and Diagnosis of Tumoral Intraepithelial Neoplasms (“Adenomas” and “Intracystic Papillary Neoplasms” of WHO-2010) of the Gallbladder (2013)
  • Author(s): Adsay V, et al.
  • Organizer: The 102nd The Annual Meeting of United State and Canadian Academy of Pathology,
  • Place of Presentation: 米国メリーランド州ボルチモア
• [Presentation] 浸潤性膵癌とその前駆病変 -病理学的視点から- (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第75回 東北膵胆道疾患検討会
  • Place of Presentation: 仙台
  • Year and Date: 2012-07-20
• [Presentation] 膵腫瘍 WHO 分類 2010 の概要 (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第101回 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 小膵癌(ts1)の臨床病理学的検討 (2012)
  • Author(s): 今田浩生
  • Organizer: 第101回 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] IPMN についての日本と欧米での考え方・取扱いの違い-病理の立場から (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-19
• [Presentation] 膵腫瘍WHO分類2010の概要 (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第101回 日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] IPMNについての日本と欧米での考え方・取扱いの違い－病理の立場から． (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第98回 日本消化器病学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 膵IPMN切除後残膵再発症例の画像および病理学的検討． (2012)
  • Author(s): 笹沼英紀，ほか
  • Organizer: 第43回 日本膵臓学会
  • Place of Presentation: 山形
• [Presentation] 浸潤性膵癌とその前駆病変 －病理学的視点から－ (2012)
  • Author(s): 福嶋敬宜
  • Organizer: 第75回 東北膵胆道疾患検討会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 小膵癌（ts1）の臨床病理学的検討 (2012)
  • Author(s): 今田浩生、ほか
  • Organizer: 第101回 日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 消化器神経内分泌腫瘍の病理診断 ～分類の変遷と新たな展開～ (2011)
  • Author(s): 福嶋敬宜
  • Organizer: 第38回日本神経内分泌学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-25
• [Presentation] 消化器神経内分泌腫瘍の病理診断:分類の変遷と新たな展開 (2011)
  • Author(s): 福嶋敬宜
  • Organizer: 第38回日本神経内分泌学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-25
• [Presentation] 早期"膵癌と前駆病変- 病理学的視点から- (2011)
  • Author(s): 福嶋敬宜
  • Organizer: 第12回北海道消化器画像・MIT 研究
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-25
• [Presentation] 膵・胆管粘液産生腫瘍の病理 (2011)
  • Author(s): 福嶋敬宜
  • Organizer: 第9回病理・細胞診セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2011-01-15
• [Presentation] 胆膵腫瘍の病理診断-新 WHO 分類での改訂点もふまえて- (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第22回北陸病理集談会
  • Place of Presentation: 福井
  • Year and Date: 2010-10-23
• [Presentation] 胆膵腫瘍の病理診断-新WHO分類での改訂点もふまえて (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第22回北陸病理集談会
  • Place of Presentation: 福井
  • Year and Date: 2010-10-23
• [Presentation] 病理組織形態学を基盤にした膵癌の前駆病変・癌間質へのアプローチ (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 自治医大シンポジウム
  • Place of Presentation: 栃木
  • Year and Date: 2010-09-04
• [Presentation] 胆膵病変の病理-新 WHO 分類(2010)での変更点もふまえて (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第31回備後肝胆膵研究会
  • Place of Presentation: 福山
  • Year and Date: 2010-06-24
• [Presentation] 胆膵病変の病理-新WHO分類(2010)での変更点もふまえて (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第31回備後肝胆膵研究会
  • Place of Presentation: 広島
  • Year and Date: 2010-06-24
• [Presentation] 膵腫瘍WHO分類(第4版)の概要と改訂のポイント (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第99回 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] 膵腫瘍 WHO 分類(第4 版)の概要と改訂のポイント. (2010)
  • Author(s): 福嶋敬宜
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Book] 腫瘍性膵疾患 (2013)
  • Author(s): 福嶋敬宜
  • Publisher: 文光堂
• [Book] 病理学・病理検査学 (2012)
  • Author(s): 福嶋敬宜
  • Total Pages: 296
  • Publisher: 医学書院
• [Book] 臨床に活かす病理診断学-消化管・肝胆膵編 (2011)
  • Author(s): 福嶋敬宜
  • Publisher: 医学書院
• [Book] 臨床に活かす病理診断学-消化管・肝胆膵編 (2011)
  • Author(s): 福嶋敬宜, ほか
  • Total Pages: 300
  • Publisher: 医学書院
• [Book] Secondary tumours of the pancreas (2010)
  • Author(s): Iacobuzio-Donahue C,Fukushima N
  • Total Pages: 333
  • Publisher: IARC Press
• [Book] Diagnostic algorithms for tumours of the pancreas (2010)
  • Author(s): Klimstra DS, Fukushima N, Hruban RH, Kloppel G.
  • Publisher: IARC Press
• [Book] Ductal adenocarcinoma variants and mixed neoplasms of the pancreas. (2010)
  • Author(s): Fukushima N, Hruban RH, Kato Y, et al.
  • Publisher: IARC Press
• [Book] Serous cystic neoplasms of the pancreas (2010)
  • Author(s): Benoit Terris B, Fukushima N, Hruban RH
  • Publisher: IARC Press
• [Book] Mucinous cystic neoplasms of the pancreas (2010)
  • Author(s): Zamboni G, Fukushima N, Hruban RH, Kloppel G
  • Publisher: IARC Press
• [Book] Intraductal neoplasms of the pancreas (2010)
  • Author(s): Adsay NV, Fukushima N (他 8 名, 2 番目)
  • Publisher: IARC Press
• [Book] WHO Classification of Tumours of the Digestive System, 4th edition (Eds : Bosman, Hruban, Carneiro, Theise) (2010)
  • Author(s): Fukushima N, et al.
  • Total Pages: 27
  • Publisher: IARC Press
• [Remarks] 自治医科大学 研究シーズ集
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=h3en6ei9f4r65638ve57ji19vatbg3&resultCd=1&sectionCd=96
• [Remarks]
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/SyozokuListTop.php